Associations of obesity and body fat distribution with incident atrial fibrillation in the biracial health aging and body composition cohort of older adults - PubMed (original) (raw)

Multicenter Study

Associations of obesity and body fat distribution with incident atrial fibrillation in the biracial health aging and body composition cohort of older adults

Konstantinos N Aronis et al. Am Heart J. 2015 Sep.

Abstract

Obesity is a well-recognized risk factor for atrial fibrillation (AF), yet adiposity measures other than body mass index (BMI) have had limited assessment in relation to AF risk. We examined the associations of adiposity measures with AF in a biracial cohort of older adults. Given established racial differences in obesity and AF, we assessed for differences by black and white race in relating adiposity and AF.

Methods: We analyzed data from 2,717 participants of the Health, Aging, and Body Composition Study. Adiposity measures were BMI, abdominal circumference, subcutaneous and visceral fat area, and total and percent fat mass. We determined the associations between the adiposity measures and 10-year incidence of AF using Cox proportional hazards models and assessed for their racial differences in these estimates.

Results: In multivariable-adjusted models, 1-SD increases in BMI, abdominal circumference, and total fat mass were associated with a 13% to 16% increased AF risk (hazard ratio [HR] 1.14, 95% CI 1.02-1.28; HR 1.16, 95% CI 1.04-1.28; and HR 1.13, 95% CI 1.002-1.27). Subcutaneous and visceral fat areas were not significantly associated with incident AF. We did not identify racial differences in the associations between the adiposity measures and AF.

Conclusion: Body mass index, abdominal circumference, and total fat mass are associated with risk of AF for 10years among white and black older adults. Obesity is one of a limited number of modifiable risk factors for AF; future studies are essential to evaluate how obesity reduction can modify the incidence of AF.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: The authors have no conflict of interest to disclose.

Figures

Figure 1

Multivariable-adjusted restricted cubic splines relating (a) BMI (b) abdominal circumference and risk of AF in whites and blacks participants of the Health ABC cohort. A BMI of 27 mg/kg2 and an abdominal circumference of 99 cm were used as a reference since they represent the median of each variable’s distribution. The solid line demonstrates a progressively increased AF risk in whites and the dashed line demonstrates a progressively increased AF risk in blacks. AF risk increases linearly as BMI and abdominal circumference increase, while there is no significant interaction by race. The shaded areas indicate the 95% confidence intervals.

Cited by

Are cardiovascular risk factors also associated with the incidence of atrial fibrillation? A systematic review and field synopsis of 23 factors in 32 population-based cohorts of 20 million participants.
Allan V, Honarbakhsh S, Casas JP, Wallace J, Hunter R, Schilling R, Perel P, Morley K, Banerjee A, Hemingway H. Allan V, et al. Thromb Haemost. 2017 May 3;117(5):837-850. doi: 10.1160/TH16-11-0825. Epub 2017 Feb 23. Thromb Haemost. 2017. PMID: 28229164 Free PMC article. Review.
Body Composition in Patients with Atrial Fibrillation.
Anaszewicz M, Banaś W, Wawrzeńczyk A, Budzyński J. Anaszewicz M, et al. Acta Cardiol Sin. 2019 Sep;35(5):484-492. doi: 10.6515/ACS.201909_35(5).20190323A. Acta Cardiol Sin. 2019. PMID: 31571797 Free PMC article.
Adiposity-associated atrial fibrillation: molecular determinants, mechanisms, and clinical significance.
Gawałko M, Saljic A, Li N, Abu-Taha I, Jespersen T, Linz D, Nattel S, Heijman J, Fender A, Dobrev D. Gawałko M, et al. Cardiovasc Res. 2023 May 2;119(3):614-630. doi: 10.1093/cvr/cvac093. Cardiovasc Res. 2023. PMID: 35689487 Free PMC article. Review.
The Impact of Metabolic Syndrome on the Incidence of Atrial Fibrillation: A Nationwide Longitudinal Cohort Study in South Korea.
Kwon CH, Kim H, Kim SH, Kim BS, Kim HJ, Kim DK, Han SW, Ryu KH, Dong Sung J. Kwon CH, et al. J Clin Med. 2019 Jul 24;8(8):1095. doi: 10.3390/jcm8081095. J Clin Med. 2019. PMID: 31344944 Free PMC article.
Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts: Results From the BiomarCaRE Consortium (Biomarker for Cardiovascular Risk Assessment in Europe).
Magnussen C, Niiranen TJ, Ojeda FM, Gianfagna F, Blankenberg S, Njølstad I, Vartiainen E, Sans S, Pasterkamp G, Hughes M, Costanzo S, Donati MB, Jousilahti P, Linneberg A, Palosaari T, de Gaetano G, Bobak M, den Ruijter HM, Mathiesen E, Jørgensen T, Söderberg S, Kuulasmaa K, Zeller T, Iacoviello L, Salomaa V, Schnabel RB; BiomarCaRE Consortium. Magnussen C, et al. Circulation. 2017 Oct 24;136(17):1588-1597. doi: 10.1161/CIRCULATIONAHA.117.028981. Epub 2017 Oct 16. Circulation. 2017. PMID: 29038167 Free PMC article. Clinical Trial.

References

1. Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Borden WB, et al. Heart disease and stroke statistics--2013 update: a report from the American Heart Association. Circulation. 2013;127(1):e6–e245. - PMC - PubMed
1. Miyasaka Y, Barnes ME, Gersh BJ, Cha SS, Bailey KR, Abhayaratna WP, et al. Secular trends in incidence of atrial fibrillation in Olmsted County, Minnesota, 1980 to 2000, and implications on the projections for future prevalence. Circulation. 2006;114(2):119–25. - PubMed
1. Kannel WB, Wolf PA, Benjamin EJ, Levy D. Prevalence, incidence, prognosis, and predisposing conditions for atrial fibrillation: population-based estimates. Am J Cardiol. 1998;82(8A):2N–9N. - PubMed
1. Colilla S, Crow A, Petkun W, Singer DE, Simon T, Liu X. Estimates of current and future incidence and prevalence of atrial fibrillation in the U.S. adult population. Am J Cardiol. 2013;112(8):1142–7. - PubMed
1. Magnani JW, Rienstra M, Lin H, Sinner MF, Lubitz SA, McManus DD, et al. Atrial fibrillation: current knowledge and future directions in epidemiology and genomics. Circulation. 2011;124(18):1982–93. - PMC - PubMed

Associations of obesity and body fat distribution with incident atrial fibrillation in the biracial health aging and body composition cohort of older adults - PubMed (original) (raw)