NIR-Responsive On-Demand Release of CO from Metal Carbonyl-Caged Graphene Oxide Nanomedicine - PubMed (original) (raw)

NIR-Responsive On-Demand Release of CO from Metal Carbonyl-Caged Graphene Oxide Nanomedicine

Qianjun He et al. Adv Mater. 2015 Nov.

Abstract

On-demand release of carbon monoxide (CO) is realized through a novel near-infrared-responsive nanomedicine in favor of the enhancement of therapy efficacy and biosafety of CO therapy.

Keywords: CO therapy; controlled release; drug delivery; graphene; nanomedicine.

© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Figures

Figure 1

Figure 1

AFM images (A1, B1) and dimensional histograms (A2, B2) of GO-NH2 (A) and MnCO-GO (B).

Figure 2

Figure 2

CO release profiles of MnCO-GO (3 µg/mL) in PBS under the excitation of 808-nm NIR light with different power densities (0.5, 1 and 2 W/cm2). MnCO-GO (3 µg/mL) without NIR irradiation and the equivalent molar amount of MnBr(CO)5 with 2 W/cm2 NIR irradiation were used as controls.

Figure 3

Figure 3

The NIR controllability of MnCO-GO (3 µg/mL) for CO release by switching on/off 808-nm NIR light (1 W/cm2).

Figure 4

Figure 4

Intracellular CO release profiles of MnCO-GO under the excitation of 808-nm NIR light (0.1 W/cm2) detected with COP-1: (A) qualitative observation under fluorescence microscope (upper: fluorescence images; lower: corresponding bright field images); (B) statistics of the fluorescence intensity of treated Raw264.7 cells.

Figure 5

Figure 5

The anti-inflammation effect of CO released from the MnCO-GO nanomedicine under NIR irradiation (1 W/cm2). LPS (1 µg/mL) was used to stimulate the inflammatory response of Raw264.7 cells, and the absence of LPS and nanomedicine was the blank control.

Scheme 1

Scheme 1

Molecular structure and NIR-responsive CO release mechanism of PEG-BPY[MnBr(CO)3]-GO (abbreviated as MnCO-GO). MnBr(CO)3 is caged in the bipyridine-conjugated GO. See Schemes S1 and S2 in the Supporting Information for construction of MnCO-GO. Under the excitation of NIR light, GO can absorb the energy of NIR light and then transform photons into active electrons, which are transferred from GO to bipyridines and then to coordinated Mn (green/blue arrows) and then contest the 3d orbitals of Mn with carbonyls, finally leading to the detachment of CO from Mn (pink arrows).

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