Prebiotics: why definitions matter - PubMed (original) (raw)
Review
doi: 10.1016/j.copbio.2015.09.001. Epub 2015 Sep 29.
Janina A Krumbeck 2, Laure B Bindels 3, Patrice D Cani 4, George Fahey Jr 5, Yong Jun Goh 6, Bruce Hamaker 7, Eric C Martens 8, David A Mills 9, Robert A Rastal 10, Elaine Vaughan 11, Mary Ellen Sanders 12
Affiliations
- PMID: 26431716
- PMCID: PMC4744122
- DOI: 10.1016/j.copbio.2015.09.001
Review
Prebiotics: why definitions matter
Robert W Hutkins et al. Curr Opin Biotechnol. 2016 Feb.
Abstract
The prebiotic concept was introduced twenty years ago, and despite several revisions to the original definition, the scientific community has continued to debate what it means to be a prebiotic. How prebiotics are defined is important not only for the scientific community, but also for regulatory agencies, the food industry, consumers and healthcare professionals. Recent developments in community-wide sequencing and glycomics have revealed that more complex interactions occur between putative prebiotic substrates and the gut microbiota than previously considered. A consensus among scientists on the most appropriate definition of a prebiotic is necessary to enable continued use of the term.
Copyright © 2015 Elsevier Ltd. All rights reserved.
Figures
Figure 1
Number of prebiotics publications sited in PubMed (search terms = prebiotic* AND bacteria NOT origins NOT inorganic), data for 2015 are through May.
Similar articles
- Recent Development of Prebiotic Research-Statement from an Expert Workshop.
La Fata G, Rastall RA, Lacroix C, Harmsen HJM, Mohajeri MH, Weber P, Steinert RE. La Fata G, et al. Nutrients. 2017 Dec 20;9(12):1376. doi: 10.3390/nu9121376. Nutrients. 2017. PMID: 29261110 Free PMC article. - Revisiting the Concepts of Prebiotic and Prebiotic Effect in Light of Scientific and Regulatory Progress-A Consensus Paper From the Global Prebiotic Association.
Deehan EC, Al Antwan S, Witwer RS, Guerra P, John T, Monheit L. Deehan EC, et al. Adv Nutr. 2024 Oct 29:100329. doi: 10.1016/j.advnut.2024.100329. Online ahead of print. Adv Nutr. 2024. PMID: 39481540 - Developments in understanding and applying prebiotics in research and practice-an ISAPP conference paper.
Scott KP, Grimaldi R, Cunningham M, Sarbini SR, Wijeyesekera A, Tang MLK, Lee JC, Yau YF, Ansell J, Theis S, Yang K, Menon R, Arfsten J, Manurung S, Gourineni V, Gibson GR. Scott KP, et al. J Appl Microbiol. 2020 Apr;128(4):934-949. doi: 10.1111/jam.14424. Epub 2019 Sep 12. J Appl Microbiol. 2020. PMID: 31446668 Review. - Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics.
Gibson GR, Hutkins R, Sanders ME, Prescott SL, Reimer RA, Salminen SJ, Scott K, Stanton C, Swanson KS, Cani PD, Verbeke K, Reid G. Gibson GR, et al. Nat Rev Gastroenterol Hepatol. 2017 Aug;14(8):491-502. doi: 10.1038/nrgastro.2017.75. Epub 2017 Jun 14. Nat Rev Gastroenterol Hepatol. 2017. PMID: 28611480 Review. - Prebiotic effects: metabolic and health benefits.
Roberfroid M, Gibson GR, Hoyles L, McCartney AL, Rastall R, Rowland I, Wolvers D, Watzl B, Szajewska H, Stahl B, Guarner F, Respondek F, Whelan K, Coxam V, Davicco MJ, Léotoing L, Wittrant Y, Delzenne NM, Cani PD, Neyrinck AM, Meheust A. Roberfroid M, et al. Br J Nutr. 2010 Aug;104 Suppl 2:S1-63. doi: 10.1017/S0007114510003363. Br J Nutr. 2010. PMID: 20920376 Review.
Cited by
- Appraisal of postbiotics in cancer therapy.
Sudaarsan ASK, Ghosh AR. Sudaarsan ASK, et al. Front Pharmacol. 2024 Sep 20;15:1436021. doi: 10.3389/fphar.2024.1436021. eCollection 2024. Front Pharmacol. 2024. PMID: 39372197 Free PMC article. Review. - In Vitro Utilization of Prebiotics by Listeria monocytogenes.
Kodešová T, Mašlejová A, Vlková E, Musilová Š, Horváthová K, Šubrtová Salmonová H. Kodešová T, et al. Microorganisms. 2024 Sep 11;12(9):1876. doi: 10.3390/microorganisms12091876. Microorganisms. 2024. PMID: 39338550 Free PMC article. - Edible mushrooms trending in food: Nutrigenomics, bibliometric, from bench to valuable applications.
Sharma E, Bairwa R, Lal P, Pattanayak S, Chakrapani K, Poorvasandhya R, Kumar A, Altaf MA, Tiwari RK, Lal MK, Kumar R. Sharma E, et al. Heliyon. 2024 Aug 27;10(17):e36963. doi: 10.1016/j.heliyon.2024.e36963. eCollection 2024 Sep 15. Heliyon. 2024. PMID: 39281488 Free PMC article. Review. - Gut-brain axis: A cutting-edge approach to target neurological disorders and potential synbiotic application.
Ashique S, Mohanto S, Ahmed MG, Mishra N, Garg A, Chellappan DK, Omara T, Iqbal S, Kahwa I. Ashique S, et al. Heliyon. 2024 Jul 4;10(13):e34092. doi: 10.1016/j.heliyon.2024.e34092. eCollection 2024 Jul 15. Heliyon. 2024. PMID: 39071627 Free PMC article. Review. - Bioactive Hydrogel Formulation Based on Ferulic Acid-Grafted Nano-Chitosan and Bacterial Nanocellulose Enriched with Selenium Nanoparticles from Kombucha Fermentation.
Tritean N, Dimitriu L, Dima ȘO, Ghiurea M, Trică B, Nicolae CA, Moraru I, Nicolescu A, Cimpean A, Oancea F, Constantinescu-Aruxandei D. Tritean N, et al. J Funct Biomater. 2024 Jul 22;15(7):202. doi: 10.3390/jfb15070202. J Funct Biomater. 2024. PMID: 39057323 Free PMC article.
References
- Tanaka R, Takayama H, Morotomi M, Kuroshima T, Ueyama S, Matsumoto K, Kuroda A, Mutai M. Effects of administration of TOS and Bifidobacterium breve 4006 on the human fecal flora. Bifidobact Microflora. 1983;2:17–24.
- Okazaki M, Fujikawa S, Matsumoto N. Effect of xylooligasaccharide on the growth of bifidobacteria. Bifidobact Microflora. 1990;9:77–86.
- Ito M, Deuguchi Y, Miyamori A, Matsumote K, Kikuchi H, Matsumoto K, Yajima T, Kan T. Effects of administration of galactooligosaccharides on the human faecal microflora, stool weigh and abdominal sensation. Microb Ecol Health Dis. 1990;3:285–292.
- Hidaka H, Tashiro Y, Eida T. Proliferation of bifidobacteria by oligosaccharides and their useful effect on human health. Bifidobact Microflora. 1991;10:65–79.
- György P, Norris RF, Rose SR. Bifidus factor. I. A variant of Lactobacillus bifidus requiring a special growth factor. Arch Biochem Biophys. 1954;48:193–201. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
- 336452/ERC_/European Research Council/International
- R01AT008759/AT/NCCIH NIH HHS/United States
- R01AT007079/AT/NCCIH NIH HHS/United States
- R01 AT008759/AT/NCCIH NIH HHS/United States
- R01 AT007079/AT/NCCIH NIH HHS/United States
LinkOut - more resources
Full Text Sources
Other Literature Sources