In Brief: Endothelial-to-mesenchymal transition - PubMed (original) (raw)

. 2016 Feb;238(3):378-80.

doi: 10.1002/path.4653. Epub 2016 Jan 4.

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In Brief: Endothelial-to-mesenchymal transition

Gonzalo Sanchez-Duffhues et al. J Pathol. 2016 Feb.

Abstract

Recent evidence has highlighted the role of endothelial-to-mesenchymal transition (EndoMT) in the onset and progression of a number of human pathologies. EndoMT involves the loss of an endothelial signature to generate unspecialized mesenchymal-like cells, susceptible to being re-differentiated into mesodermal cell types, including osteoblasts, chondrocytes, and adipocytes. Therefore, modulation of the molecular pathways controlling EndoMT can be considered as a therapeutic approach for particular human diseases. In addition, EndoMT may be harnessed for tissue engineering by producing multipotent mesenchymal cells able to differentiate into mutiple cell types.

Keywords: EndoMT; TGF-β; endothelial cell; β-catenin.

Copyright © 2015 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

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