Hippocampal insulin resistance and cognitive dysfunction - PubMed (original) (raw)

Review

. 2015 Nov;16(11):660-71.

doi: 10.1038/nrn4019. Epub 2015 Oct 14.

Affiliations

• PMID: 26462756
• DOI: 10.1038/nrn4019

Review

Hippocampal insulin resistance and cognitive dysfunction

Geert Jan Biessels et al. Nat Rev Neurosci. 2015 Nov.

Abstract

Clinical studies suggest a link between type 2 diabetes mellitus (T2DM) and insulin resistance (IR) and cognitive dysfunction, but there are significant gaps in our knowledge of the mechanisms underlying this relationship. Animal models of IR help to bridge these gaps and point to hippocampal IR as a potential mediator of cognitive dysfunction in T2DM, as well as in Alzheimer disease (AD). This Review highlights these observations and discusses intervention studies which suggest that the restoration of insulin activity in the hippocampus may be an effective strategy to alleviate the cognitive decline associated with T2DM and AD.

PubMed Disclaimer

Similar articles

• Patients with type 2 diabetes exhibit cognitive impairment with changes of metabolite concentration in the left hippocampus.
  Wang Y, Xu XY, Feng CH, Li YL, Ge X, Zong GL, Wang YB, Feng B, Zhang P. Wang Y, et al. Metab Brain Dis. 2015 Aug;30(4):1027-34. doi: 10.1007/s11011-015-9670-4. Epub 2015 Apr 16. Metab Brain Dis. 2015. PMID: 25875132 Free PMC article.
• The brain in the age of old: the hippocampal formation is targeted differentially by diseases of late life.
  Wu W, Brickman AM, Luchsinger J, Ferrazzano P, Pichiule P, Yoshita M, Brown T, DeCarli C, Barnes CA, Mayeux R, Vannucci SJ, Small SA. Wu W, et al. Ann Neurol. 2008 Dec;64(6):698-706. doi: 10.1002/ana.21557. Ann Neurol. 2008. PMID: 19107993 Free PMC article.
• Insulin resistance and hippocampal dysfunction: Disentangling peripheral and brain causes from consequences.
  Grillo CA, Woodruff JL, Macht VA, Reagan LP. Grillo CA, et al. Exp Neurol. 2019 Aug;318:71-77. doi: 10.1016/j.expneurol.2019.04.012. Epub 2019 Apr 24. Exp Neurol. 2019. PMID: 31028829 Review.
• High-sensitivity C-reactive protein is associated with hippocampus volume in nondementia patients with type 2 diabetes mellitus.
  Anan F, Masaki T, Shimomura T, Fujiki M, Umeno Y, Eshima N, Saikawa T, Yoshimatsu H. Anan F, et al. Metabolism. 2011 Apr;60(4):460-6. doi: 10.1016/j.metabol.2010.04.002. Epub 2010 May 26. Metabolism. 2011. PMID: 20537668

Cited by

• Abnormal resting-state functional connectivity of hippocampal subregions in type 2 diabetes mellitus-associated cognitive decline.
  Yao L, Li MY, Wang KC, Liu YZ, Zheng HZ, Zhong Z, Ma SQ, Yang HM, Sun MM, He M, Huang HP, Wang HF. Yao L, et al. Front Psychiatry. 2024 Sep 23;15:1360623. doi: 10.3389/fpsyt.2024.1360623. eCollection 2024. Front Psychiatry. 2024. PMID: 39376966 Free PMC article.
• Angiotensin receptor blockade with olmesartan alleviates brain pathology in obese OLETF rats.
  Rodriguez-Ortiz CJ, Thorwald MA, Rodriguez R, Mejias-Ortega M, Kieu Z, Maitra N, Hawkins C, Valenzuela J, Peng M, Nishiyama A, Ortiz RM, Kitazawa M. Rodriguez-Ortiz CJ, et al. Clin Exp Pharmacol Physiol. 2023 Mar;50(3):228-237. doi: 10.1111/1440-1681.13738. Epub 2022 Dec 4. Clin Exp Pharmacol Physiol. 2023. PMID: 36398458 Free PMC article.
• Prenatal Stress-induced Spatial Memory Deficit in a Sex-specific Manner in Mice: A Possible Involvement of Hippocampal Insulin Resistance.
  Mohammadi M, Rohani AH, Yaghmaei P, Sahraei H. Mohammadi M, et al. Basic Clin Neurosci. 2022 May-Jun;13(3):275-283. doi: 10.32598/bcn.2021.15.12. Epub 2022 May 1. Basic Clin Neurosci. 2022. PMID: 36457886 Free PMC article.
• Amyloid, tau, pathogen infection and antimicrobial protection in Alzheimer's disease -conformist, nonconformist, and realistic prospects for AD pathogenesis.
  Li H, Liu CC, Zheng H, Huang TY. Li H, et al. Transl Neurodegener. 2018 Dec 24;7:34. doi: 10.1186/s40035-018-0139-3. eCollection 2018. Transl Neurodegener. 2018. PMID: 30603085 Free PMC article. Review.
• Effects of Subcortical Atrophy and Alzheimer's Pathology on Cognition in Elderly Type 2 Diabetes: The Alzheimer's Disease Neuroimaging Initiative Study.
  Zhang W, Lu J, Qing Z, Zhang X, Zhao H, Bi Y, Zhang B; Alzheimer’s Disease Neuroimaging Initiative. Zhang W, et al. Front Aging Neurosci. 2022 Jan 31;14:781938. doi: 10.3389/fnagi.2022.781938. eCollection 2022. Front Aging Neurosci. 2022. PMID: 35173604 Free PMC article.

References

1. 1. J Endocrinol. 2013 May 28;218(1):1-11 - PubMed
2. 1. FASEB J. 2008 Jan;22(1):246-60 - PubMed
3. 1. Pharmacology. 2010;86(1):44-57 - PubMed
4. 1. Behav Neural Biol. 1990 Jan;53(1):74-87 - PubMed
5. 1. Behav Neurosci. 1996 Jun;110(3):451-9 - PubMed

Publication types

MeSH terms

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information