Aspirin-Exacerbated Diseases: Advances in Asthma with Nasal Polyposis, Urticaria, Angioedema, and Anaphylaxis - PubMed (original) (raw)
Review
Aspirin-Exacerbated Diseases: Advances in Asthma with Nasal Polyposis, Urticaria, Angioedema, and Anaphylaxis
Whitney Stevens et al. Curr Allergy Asthma Rep. 2015 Dec.
Abstract
Aspirin-exacerbated diseases are important examples of drug hypersensitivities and include aspirin-exacerbated respiratory disease (AERD), aspirin- or non-steroidal anti-inflammatory drug (NSAID)-induced urticaria/angioedema, and aspirin- or NSAID-induced anaphylaxis. While each disease subtype may be distinguished by unique clinical features, the underlying mechanisms that contribute to these phenotypes are not fully understood. However, the inhibition of the cyclooxygenase-1 enzyme is thought to play a significant role. Additionally, eosinophils, mast cells, and their products, prostaglandins and leukotrienes, have been identified in the pathogenesis of AERD. Current diagnostic and treatment strategies for aspirin-exacerbated diseases remain limited, and continued research focusing on each of the unique hypersensitivity reactions to aspirin is essential. This will not only advance the understanding of these disease processes, but also lead to the subsequent development of novel therapeutics that patients who suffer from aspirin-induced reactions desperately need.
Keywords: Anaphylaxis; Angioedema; Aspirin hypersensitivity; Aspirin-exacerbated respiratory disease (AERD); Nasal polyposis; Urticaria.
Similar articles
- Cofactors and comorbidities in patients with aspirin/NSAID hypersensitivity.
Sánchez-Borges M, Caballero-Fonseca F, Capriles-Hulett A. Sánchez-Borges M, et al. Allergol Immunopathol (Madr). 2017 Nov-Dec;45(6):573-578. doi: 10.1016/j.aller.2016.08.010. Epub 2016 Nov 17. Allergol Immunopathol (Madr). 2017. PMID: 27865540 Review. - Management of patients with nonaspirin-exacerbated respiratory disease aspirin hypersensitivity reactions.
Saff RR, Banerji A. Saff RR, et al. Allergy Asthma Proc. 2015 Jan-Feb;36(1):34-9. doi: 10.2500/aap.2015.36.3800. Allergy Asthma Proc. 2015. PMID: 25562554 Review. - Anosmia and an uncommon nonsteroidal anti-inflammatory drug reaction in a 38-year-old man.
Speck AL, Baldwin JL. Speck AL, et al. Allergy Asthma Proc. 2013 May-Jun;34(3):292-6. doi: 10.2500/aap.2013.34.3650. Allergy Asthma Proc. 2013. PMID: 23676579 - Oral drug challenges in non-steroidal anti-inflammatory drug-induced urticaria, angioedema and anaphylaxis.
Chaudhry T, Hissaria P, Wiese M, Heddle R, Kette F, Smith WB. Chaudhry T, et al. Intern Med J. 2012 Jun;42(6):665-71. doi: 10.1111/j.1445-5994.2011.02601.x. Intern Med J. 2012. PMID: 21981353 - Mediator release after nasal aspirin provocation supports different phenotypes in subjects with hypersensitivity reactions to NSAIDs.
Campo P, Ayuso P, Salas M, Plaza MC, Cornejo-García JA, Doña I, Torres MJ, Blanca-López N, Canto G, Guéant JL, Sanak M, Blanca M. Campo P, et al. Allergy. 2013 Aug;68(8):1001-7. doi: 10.1111/all.12187. Epub 2013 Jul 29. Allergy. 2013. PMID: 23889565
Cited by
- Practical Management of Patients with a History of Immediate Hypersensitivity to Common non-Beta-Lactam Drugs.
Macy E. Macy E. Curr Allergy Asthma Rep. 2016 Jan;16(1):4. doi: 10.1007/s11882-015-0584-3. Curr Allergy Asthma Rep. 2016. PMID: 26714689 Review. - Retinoic acid promotes fibrinolysis and may regulate polyp formation.
Sakashita M, Takabayashi T, Imoto Y, Homma T, Yoshida K, Ogi K, Kimura Y, Kato A, Stevens WW, Smith SS, Welch KC, Norton JE, Suh LA, Carter RG, Hulse KE, Seshadri S, Min JY, Pothoven KL, Conley DB, Tan BK, Harris KE, Kern RC, Haruna S, Matsuwaki Y, Ochiai R, Fujieda S, Schleimer RP. Sakashita M, et al. J Allergy Clin Immunol. 2022 Nov;150(5):1114-1124.e3. doi: 10.1016/j.jaci.2022.05.021. Epub 2022 Jun 18. J Allergy Clin Immunol. 2022. PMID: 35728655 Free PMC article. - Expression of DACT1 in children with asthma and its regulation mechanism.
Zhang C, Yang P, Chen Y, Liu J, Yuan X. Zhang C, et al. Exp Ther Med. 2018 Mar;15(3):2674-2680. doi: 10.3892/etm.2018.5706. Epub 2018 Jan 5. Exp Ther Med. 2018. PMID: 29456669 Free PMC article. - [Personalized medicine in allergology].
Pfützner W, Pickert J, Möbs C. Pfützner W, et al. Hautarzt. 2019 Jan;70(1):5-14. doi: 10.1007/s00105-018-4320-5. Hautarzt. 2019. PMID: 30515524 Review. German. - Pediatric Angioedema.
Pattanaik D, Lieberman JA. Pattanaik D, et al. Curr Allergy Asthma Rep. 2017 Aug 8;17(9):60. doi: 10.1007/s11882-017-0729-7. Curr Allergy Asthma Rep. 2017. PMID: 28791569 Review.
References
- J Allergy Clin Immunol. 2013 Oct;132(4):856-65.e1-3 - PubMed
- Exp Lung Res. 2014 Dec;40(10):485-94 - PubMed
- Clin Gastroenterol Hepatol. 2011 Sep;9(9):762-768.e6 - PubMed
- PLoS One. 2014 Dec 23;9(12):e111220 - PubMed
- J Allergy Clin Immunol. 2008 Jan;121(1):81-7 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical