The burgeoning family of unconventional T cells - PubMed (original) (raw)

Review

. 2015 Nov;16(11):1114-23.

doi: 10.1038/ni.3298.

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• PMID: 26482978
• DOI: 10.1038/ni.3298

Review

The burgeoning family of unconventional T cells

Dale I Godfrey et al. Nat Immunol. 2015 Nov.

Erratum in

• Corrigendum: The burgeoning family of unconventional T cells.
  Godfrey DI, Uldrich AP, McCluskey J, Rossjohn J, Moody DB. Godfrey DI, et al. Nat Immunol. 2016 Feb;17(2):214. doi: 10.1038/ni0216-214a. Nat Immunol. 2016. PMID: 26784266 No abstract available.
• Corrigendum: The burgeoning family of unconventional T cells.
  Godfrey DI, Uldrich AP, McCluskey J, Rossjohn J, Moody DB. Godfrey DI, et al. Nat Immunol. 2016 Apr;17(4):469. doi: 10.1038/ni0416-469a. Nat Immunol. 2016. PMID: 27002846 No abstract available.

Abstract

While most studies of T lymphocytes have focused on T cells reactive to complexes of peptide and major histocompatibility complex (MHC) proteins, many other types of T cells do not fit this paradigm. These include CD1-restricted T cells, MR1-restricted mucosal associated invariant T cells (MAIT cells), MHC class Ib-reactive T cells, and γδ T cells. Collectively, these T cells are considered 'unconventional', in part because they can recognize lipids, small-molecule metabolites and specially modified peptides. Unlike MHC-reactive T cells, these apparently disparate T cell types generally show simplified patterns of T cell antigen receptor (TCR) expression, rapid effector responses and 'public' antigen specificities. Here we review evidence showing that unconventional T cells are an abundant component of the human immune system and discuss the immunotherapeutic potential of these cells and their antigenic targets.

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