TRIM-NHL proteins in development and disease - PubMed (original) (raw)
Review
TRIM-NHL proteins in development and disease
Cristina Tocchini et al. Semin Cell Dev Biol. 2015 Dec.
Free article
Abstract
TRIM-NHL proteins are key regulators of developmental transitions, for example promoting differentiation, while inhibiting cell growth and proliferation, in stem and progenitor cells. Abnormalities in these proteins have been also associated with human diseases, particularly affecting muscular and neuronal functions, making them potential targets for therapeutic intervention. The purpose of this review is to provide a systematic and comprehensive summary on the most studied TRIM-NHL proteins, highlighting examples where connections were established between structural features, molecular functions and biological outcomes.
Keywords: Bardet-Biedl syndrome; Brat; LIN-41; Limb girdle muscular dystrophy 2H; Mei-P26; NHL; Sarcotubular myopathy; TRIM; TRIM32; TRIM71.
Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.
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