Deleterious effects of lard-enriched diet on tissues fatty acids composition and hypothalamic insulin actions - PubMed (original) (raw)

Deleterious effects of lard-enriched diet on tissues fatty acids composition and hypothalamic insulin actions

A P S Dornellas et al. Prostaglandins Leukot Essent Fatty Acids. 2015 Dec.

Abstract

Altered tissue fatty acid (FA) composition may affect mechanisms involved in the control of energy homeostasis, including central insulin actions. In rats fed either standard chow or a lard-enriched chow (high in saturated/low in polyunsaturated FA, HS-LP) for eight weeks, we examined the FA composition of blood, hypothalamus, liver, and retroperitoneal, epididymal and mesenteric adipose tissues. Insulin-induced hypophagia and hypothalamic signaling were evaluated after intracerebroventricular insulin injection. HS-LP feeding increased saturated FA content in adipose tissues and serum while it decreased polyunsaturated FA content of adipose tissues, serum, and liver. Hypothalamic C20:5n-3 and C20:3n-6 contents increased while monounsaturated FA content decreased. HS-LP rats showed hyperglycemia, impaired insulin-induced hypophagia and hypothalamic insulin signaling. The results showed that, upon HS-LP feeding, peripheral tissues underwent potentially deleterious alterations in their FA composition, whist the hypothalamus was relatively preserved. However, hypothalamic insulin signaling and hypophagia were drastically impaired. These findings suggest that impairment of hypothalamic insulin actions by HS-LP feeding was not related to tissue FA composition.

Keywords: Adipose tissue; Diet; Fatty acid; Hypothalamus; Insulin signaling; Obesity.

PubMed Disclaimer

Comment in

Comment on Dornellas et al., Deleterious effects of lard-enriched diet on tissues fatty acids composition and hypothalamic insulin actions, Prostaglandins, Leukot. Essent. Fat. Acids., 102-103 (2015) 21-29.
Weijers RN. Weijers RN. Prostaglandins Leukot Essent Fatty Acids. 2016 Apr;107:22-3. doi: 10.1016/j.plefa.2016.03.002. Epub 2016 Mar 8. Prostaglandins Leukot Essent Fatty Acids. 2016. PMID: 27033422 No abstract available.

Cited by

Dietary Supplementation With Tinospora cordifolia Improves Anxiety-Type Behavior and Cognitive Impairments in Middle-Aged Acyclic Female Rats.
Bhandari A, Sunkaria A, Kaur G. Bhandari A, et al. Front Aging Neurosci. 2022 Jul 28;14:944144. doi: 10.3389/fnagi.2022.944144. eCollection 2022. Front Aging Neurosci. 2022. PMID: 35966795 Free PMC article.
Supplementation of carotenoids from peach palm waste (Bactris gasipaes) obtained with an ionic liquid mediated process displays kidney anti-inflammatory and antioxidant outcomes.
Santamarina AB, de Souza Mesquita LM, Casagrande BP, Sertorio MN, Vitor de Souza D, Mennitti LV, Ribeiro DA, Estadella D, Ventura SPM, de Rosso VV, Pisani LP. Santamarina AB, et al. Food Chem X. 2022 Feb 4;13:100245. doi: 10.1016/j.fochx.2022.100245. eCollection 2022 Mar 30. Food Chem X. 2022. PMID: 35499011 Free PMC article.
Oestrogen replacement fails to fully revert ovariectomy-induced changes in adipose tissue monoglycerides, diglycerides and cholesteryl esters of rats fed a lard-enriched diet.
Boldarine VT, Joyce E, Pedroso AP, Telles MM, Oyama LM, Bueno AA, Ribeiro EB. Boldarine VT, et al. Sci Rep. 2021 Feb 15;11(1):3841. doi: 10.1038/s41598-021-82837-6. Sci Rep. 2021. PMID: 33589704 Free PMC article.
Polyphenols-Rich Fruit (Euterpe edulis Mart.) Prevents Peripheral Inflammatory Pathway Activation by the Short-Term High-Fat Diet.
Santamarina AB, Jamar G, Mennitti LV, Ribeiro DA, Cardoso CM, de Rosso VV, Oyama LM, Pisani LP. Santamarina AB, et al. Molecules. 2019 Apr 27;24(9):1655. doi: 10.3390/molecules24091655. Molecules. 2019. PMID: 31035535 Free PMC article.

Deleterious effects of lard-enriched diet on tissues fatty acids composition and hypothalamic insulin actions - PubMed (original) (raw)