Benzoic acid and its derivatives as naturally occurring compounds in foods and as additives: Uses, exposure, and controversy - PubMed (original) (raw)
Review
Benzoic acid and its derivatives as naturally occurring compounds in foods and as additives: Uses, exposure, and controversy
Ana Del Olmo et al. Crit Rev Food Sci Nutr. 2017.
Abstract
Benzoic acid is an aromatic carboxylic acid naturally present in plant and animal tissues, which can also be produced by microorganisms. Benzoic acid and a wide range of derivatives and related benzenic compounds, such as salts, alkyl esters, parabens, benzyl alcohol, benzaldehyde, and benzoyl peroxide, are commonly used as antibacterial and antifungal preservatives and as flavoring agents in food, cosmetic, hygiene, and pharmaceutical products. As a result of their widespread occurrence, production, and uses, these compounds are largely distributed in the environment and found in water, soil, and air. Consequently, human exposure to them can be high, common, and lengthy. This review is mainly focused on the presence and use of benzoic acid in foods but it also covers the occurrence, uses, human exposure, metabolism, toxicology, analytical methods for detection, and legal limits for benzoic acid and its derivatives. Their controversial effects and potential public health concerns are discussed.
Keywords: Benzoic acid; benzoates; foods; health; parabens; toxicology.
Similar articles
- Sorbic, benzoic and propionic acids in fishery products: a survey of the South Korean market.
Kim DB, Jang GJ, Yoo M, Lee G, Yun SS, Lim HS, Kim M, Lee S. Kim DB, et al. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2018 Jun;35(6):1071-1077. doi: 10.1080/19440049.2018.1447692. Epub 2018 Mar 20. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2018. PMID: 29509066 - Safety Assessment of Benzyl Alcohol, Benzoic Acid and its Salts, and Benzyl Benzoate.
Johnson W, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Johnson W, et al. Int J Toxicol. 2017 Nov/Dec;36(3_suppl):5S-30S. doi: 10.1177/1091581817728996. Int J Toxicol. 2017. PMID: 29243541 Review. - [Use of gas chromatography for determining benzoic and sorbic acid levels in orange beverage and tomato concentrate].
Giryn H, Gruszczyńska Z. Giryn H, et al. Rocz Panstw Zakl Hig. 1990;41(5-6):217-22. Rocz Panstw Zakl Hig. 1990. PMID: 2101172 Review. Polish.
Cited by
- In silico evaluation of potential breast cancer receptor antagonists from GC-MS and HPLC identified compounds in Pleurotus ostreatus extracts.
Effiong ME, Bella-Omunagbe M, Afolabi IS, Chinedu SN. Effiong ME, et al. RSC Adv. 2024 Aug 9;14(33):23744-23771. doi: 10.1039/d4ra03832k. eCollection 2024 Jul 26. RSC Adv. 2024. PMID: 39131188 Free PMC article. - Benzoic Acid, Chlorine Dioxide, and 1-Methylcyclopropene Induce Flavonoid Metabolic Shifts in Postharvest Flowering Chinese Cabbage Revealed by High-Dimensional Analytical Data.
Yue L, Li Y, Zhong M, Chai X, Zhao P, Huang R, Kang Y, Yang X. Yue L, et al. Int J Mol Sci. 2022 May 27;23(11):6011. doi: 10.3390/ijms23116011. Int J Mol Sci. 2022. PMID: 35682691 Free PMC article. - Discovery of donor age markers from bloodstain by LC-MS/MS using a metabolic approach.
Kim HJ, Lee YR, Lee S, Kwon S, Chun YT, Hyun SH, Sung HJ, Lee J, Kang HG. Kim HJ, et al. Int J Legal Med. 2022 Jan;136(1):297-308. doi: 10.1007/s00414-021-02640-w. Epub 2021 Jul 3. Int J Legal Med. 2022. PMID: 34218338 - Biologically Active Compounds of Plants: Structure-Related Antioxidant, Microbiological and Cytotoxic Activity of Selected Carboxylic Acids.
Godlewska-Żyłkiewicz B, Świsłocka R, Kalinowska M, Golonko A, Świderski G, Arciszewska Ż, Nalewajko-Sieliwoniuk E, Naumowicz M, Lewandowski W. Godlewska-Żyłkiewicz B, et al. Materials (Basel). 2020 Oct 8;13(19):4454. doi: 10.3390/ma13194454. Materials (Basel). 2020. PMID: 33049979 Free PMC article. Review. - Quantification of parabens in marine fish samples by a rapid, simple, effective sample preparation method.
Pham PT, Quan TC, Le QT, Bui MQ, Tran AH, Phung AT, Hoang AQ, Minh TB, Tran-Lam TT, Tran HN, Tran TM. Pham PT, et al. Environ Sci Pollut Res Int. 2024 Mar;31(11):16571-16582. doi: 10.1007/s11356-024-32321-1. Epub 2024 Feb 6. Environ Sci Pollut Res Int. 2024. PMID: 38321276
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials