Recombinant human interleukin 5 is a selective eosinophil chemoattractant - PubMed (original) (raw)

Recombinant human interleukin 5 is a selective eosinophil chemoattractant

J M Wang et al. Eur J Immunol. 1989 Apr.

Abstract

Human recombinant interleukin (IL) induced migration across polycarbonate filters of human peripheral blood eosinophils. The contribution of chemotaxis vs. chemokinesis was investigated using a checkerboard design with both polycarbonate and nitrocellulose filters. When different cytokine concentrations were seeded above and below the filter, maximal induction of migration required a positive concentration gradient between the lower and upper compartments of the chamber, though some gradient-independent augmentation of migration occurred. These results indicate that induction of eosinophil migration across filter involves actual chemotaxis. The effect of IL5 was selective for eosinophils with no effect on neutrophils and monocytes. Conversely, granulocyte-macrophage colony-stimulating factor elicited migration of both eosinophils and neutrophils. Thus, human IL5 is a potent and selective chemoattractant for human eosinophils. Eosinophils are selectively localized in tissues under a variety of physiological and pathological conditions. Locally produced IL5 may play a role in the selective recruitment of eosinophils from the blood compartment.

PubMed Disclaimer

Similar articles

• Induction of monocyte migration by recombinant macrophage colony-stimulating factor.
  Wang JM, Griffin JD, Rambaldi A, Chen ZG, Mantovani A. Wang JM, et al. J Immunol. 1988 Jul 15;141(2):575-9. J Immunol. 1988. PMID: 3290341
• Tumor necrosis factor is chemotactic for monocytes and polymorphonuclear leukocytes.
  Ming WJ, Bersani L, Mantovani A. Ming WJ, et al. J Immunol. 1987 Mar 1;138(5):1469-74. J Immunol. 1987. PMID: 3805724
• Chemotactic activity of recombinant human granulocyte colony-stimulating factor.
  Wang JM, Chen ZG, Colella S, Bonilla MA, Welte K, Bordignon C, Mantovani A. Wang JM, et al. Blood. 1988 Nov;72(5):1456-60. Blood. 1988. PMID: 2460152
• Mechanisms of eosinophil recruitment.
  Resnick MB, Weller PF. Resnick MB, et al. Am J Respir Cell Mol Biol. 1993 Apr;8(4):349-55. doi: 10.1165/ajrcmb/8.4.349. Am J Respir Cell Mol Biol. 1993. PMID: 8476627 Review.
• Isolation of eosinophils from human blood.
  Hansel TT, Pound JD, Thompson RA. Hansel TT, et al. J Immunol Methods. 1990 Mar 9;127(2):153-64. doi: 10.1016/0022-1759(90)90064-3. J Immunol Methods. 1990. PMID: 2179410 Review. No abstract available.

Cited by

• The Efficacy of Cancer Immunotherapies Is Compromised by Helicobacter pylori Infection.
  Oster P, Vaillant L, McMillan B, Velin D. Oster P, et al. Front Immunol. 2022 May 23;13:899161. doi: 10.3389/fimmu.2022.899161. eCollection 2022. Front Immunol. 2022. PMID: 35677057 Free PMC article. Review.
• [Allergic reactions to bioimplants].
  Klimek L. Klimek L. HNO. 2022 May;70(5):361-370. doi: 10.1007/s00106-022-01173-x. Epub 2022 Mar 28. HNO. 2022. PMID: 35344067 Review. German.
• Eosinophils and eosinophil-associated disorders: immunological, clinical, and molecular complexity.
  Valent P, Degenfeld-Schonburg L, Sadovnik I, Horny HP, Arock M, Simon HU, Reiter A, Bochner BS. Valent P, et al. Semin Immunopathol. 2021 Jun;43(3):423-438. doi: 10.1007/s00281-021-00863-y. Epub 2021 May 30. Semin Immunopathol. 2021. PMID: 34052871 Free PMC article. Review.
• Targeted therapy in eosinophilic chronic obstructive pulmonary disease.
  Fieldes M, Bourguignon C, Assou S, Nasri A, Fort A, Vachier I, De Vos J, Ahmed E, Bourdin A. Fieldes M, et al. ERJ Open Res. 2021 Apr 12;7(2):00437-2020. doi: 10.1183/23120541.00437-2020. eCollection 2021 Apr. ERJ Open Res. 2021. PMID: 33855061 Free PMC article. Review.
• OK-432 Acts as Adjuvant to Modulate T Helper 2 Inflammatory Responses in a Murine Model of Asthma.
  Wu CJ, Tseng PH, Chan CC, Quon S, Chen LC, Kuo ML. Wu CJ, et al. J Immunol Res. 2018 Oct 8;2018:1697276. doi: 10.1155/2018/1697276. eCollection 2018. J Immunol Res. 2018. PMID: 30402504 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Wiley