Prospective longitudinal study of testosterone and incident depression in older men: The Health In Men Study - PubMed (original) (raw)
Prospective longitudinal study of testosterone and incident depression in older men: The Health In Men Study
Andrew H Ford et al. Psychoneuroendocrinology. 2016 Feb.
Free article
Abstract
Background: Depression in older men has been associated with low circulating testosterone concentration but data from prospective studies are limited.
Methods: We conducted a prospective longitudinal study in a community representative cohort of 3179 older men free of clinically significant depressive symptoms at baseline. The main objective of this study was to determine if low serum testosterone, dihydrotestosterone and estradiol concentrations are associated with the development of depressive symptoms. Incident depression was assessed with the Patient Health Questionnaire and via an electronic health record database (The West Australian Data Linkage System). The main exposures of interest were serum testosterone, dihydrotestosterone and estradiol measured by liquid chromatography-mass spectrometry and calculated free testosterone in baseline blood samples (collected between 2001 and 2004).
Results: One hundred and thirty five men (4.2%) developed depression over a median follow up time of 9.4 years (range 8.4-10.9). Men with incident depression were older (median age 77.7 vs 76.1 years, z=-3.82, p=0<0.001) and were more likely to have cardiovascular disease (43.0% vs 32.6%, χ(2)=6.32, p=0.012) and diabetes (22.2% vs 13.2%, χ(2)=8.95, p=0.003). Low serum total testosterone (<6.4 nmol/L) was associated with incident depression (HR 2.07, 95%CI 1.17-3.68) and this remained significant after adjustment for relevant potential confounding factors (HR 1.86, 95%CI 1.05-3.31). Low serum dihydrotestosterone, estradiol and calculated free testosterone were not associated with risk of depression.
Conclusions: Low serum total testosterone, but not calculated free testosterone, was associated with incident depression in this sample of older men.
Keywords: Depression; Older men; Testosterone.
Crown Copyright © 2015. Published by Elsevier Ltd. All rights reserved.
Similar articles
- Reference ranges and determinants of testosterone, dihydrotestosterone, and estradiol levels measured using liquid chromatography-tandem mass spectrometry in a population-based cohort of older men.
Yeap BB, Alfonso H, Chubb SA, Handelsman DJ, Hankey GJ, Norman PE, Flicker L. Yeap BB, et al. J Clin Endocrinol Metab. 2012 Nov;97(11):4030-9. doi: 10.1210/jc.2012-2265. Epub 2012 Sep 13. J Clin Endocrinol Metab. 2012. PMID: 22977273 - Sex hormones and incident dementia in older men: The health in men study.
Ford AH, Yeap BB, Flicker L, Hankey GJ, Chubb SAP, Golledge J, Almeida OP. Ford AH, et al. Psychoneuroendocrinology. 2018 Dec;98:139-147. doi: 10.1016/j.psyneuen.2018.08.013. Epub 2018 Aug 9. Psychoneuroendocrinology. 2018. PMID: 30144781 - In older men an optimal plasma testosterone is associated with reduced all-cause mortality and higher dihydrotestosterone with reduced ischemic heart disease mortality, while estradiol levels do not predict mortality.
Yeap BB, Alfonso H, Chubb SA, Handelsman DJ, Hankey GJ, Almeida OP, Golledge J, Norman PE, Flicker L. Yeap BB, et al. J Clin Endocrinol Metab. 2014 Jan;99(1):E9-18. doi: 10.1210/jc.2013-3272. Epub 2013 Dec 20. J Clin Endocrinol Metab. 2014. PMID: 24257908 - Longitudinal and cross-sectional relationships of circulating reproductive hormone levels to self-rated health and health-related quality of life in community-dwelling older men.
Hsu B, Cumming RG, Blyth FM, Naganathan V, Le Couteur DG, Seibel MJ, Waite LM, Handelsman DJ. Hsu B, et al. J Clin Endocrinol Metab. 2014 May;99(5):1638-47. doi: 10.1210/jc.2013-3984. Epub 2014 Feb 19. J Clin Endocrinol Metab. 2014. PMID: 24552220 - Testosterone and its metabolites: differential associations with cardiovascular and cerebrovascular events in men.
Yeap BB. Yeap BB. Asian J Androl. 2018 Mar-Apr;20(2):109-114. doi: 10.4103/aja.aja_50_17. Asian J Androl. 2018. PMID: 29199649 Free PMC article. Review.
Cited by
- Thyroid hormone: sex-dependent role in nervous system regulation and disease.
Baksi S, Pradhan A. Baksi S, et al. Biol Sex Differ. 2021 Mar 8;12(1):25. doi: 10.1186/s13293-021-00367-2. Biol Sex Differ. 2021. PMID: 33685490 Free PMC article. Review. - Sexual Dysfunction in Type 2 Diabetes at Diagnosis: Progression over Time and Drug and Non-Drug Correlated Factors.
Corona G, Giorda CB, Cucinotta D, Guida P, Nada E; SUBITO-DE Study Group. Corona G, et al. PLoS One. 2016 Oct 5;11(10):e0157915. doi: 10.1371/journal.pone.0157915. eCollection 2016. PLoS One. 2016. PMID: 27706160 Free PMC article. - Testosterone and Dehydroepiandrosterone Treatment in Ageing Men: Are We All Set?
Walther A, Seuffert J. Walther A, et al. World J Mens Health. 2020 Apr;38(2):178-190. doi: 10.5534/wjmh.190006. Epub 2019 Jun 4. World J Mens Health. 2020. PMID: 31190486 Free PMC article. Review. - Depression as a Neuroendocrine Disorder: Emerging Neuropsychopharmacological Approaches beyond Monoamines.
Chávez-Castillo M, Núñez V, Nava M, Ortega Á, Rojas M, Bermúdez V, Rojas-Quintero J. Chávez-Castillo M, et al. Adv Pharmacol Sci. 2019 Jan 3;2019:7943481. doi: 10.1155/2019/7943481. eCollection 2019. Adv Pharmacol Sci. 2019. PMID: 30719038 Free PMC article. Review. - Age-Related Alterations in Endocrine Markers Do Not Match Changes in Psychosocial Measures: Findings From the Men's Health 40+ Longitudinal Study.
Lacker TJ, Walther A, Ehlert U. Lacker TJ, et al. Am J Mens Health. 2020 May-Jun;14(3):1557988320926332. doi: 10.1177/1557988320926332. Am J Mens Health. 2020. PMID: 32456528 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical