Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion - PubMed (original) (raw)

Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion

J Behrens et al. J Cell Biol. 1989 Jun.

Abstract

The generation of invasiveness in transformed cells represents an essential step of tumor progression. We show here, first, that nontransformed Madin-Darby canine kidney (MDCK) epithelial cells acquire invasive properties when intercellular adhesion is specifically inhibited by the addition of antibodies against the cell adhesion molecule uvomorulin; the separated cells then invade collagen gels and embryonal heart tissue. Second, MDCK cells transformed with Harvey and Moloney sarcoma viruses are constitutively invasive, and they were found not to express uvomorulin at their cell surface. These data suggest that the loss of adhesive function of uvomorulin (which is identical to E-cadherin and homologous to L-CAM) is a critical step in the promotion of epithelial cells to a more malignant, i.e., invasive, phenotype. Similar modulation of intercellular adhesion might also occur during invasion of carcinoma cells in vivo.

PubMed Disclaimer

Cited by

Expression of N-cadherin in salivary gland tumors.
Kehagias N, Epivatianos A, Sakas L, Andreadis D, Markopoulos A, Antoniades K. Kehagias N, et al. Med Princ Pract. 2013;22(1):59-64. doi: 10.1159/000339213. Epub 2012 Jun 22. Med Princ Pract. 2013. PMID: 22738870 Free PMC article.
Cadherin-mediated cell-cell adhesion is perturbed by v-src tyrosine phosphorylation in metastatic fibroblasts.
Matsuyoshi N, Hamaguchi M, Taniguchi S, Nagafuchi A, Tsukita S, Takeichi M. Matsuyoshi N, et al. J Cell Biol. 1992 Aug;118(3):703-14. doi: 10.1083/jcb.118.3.703. J Cell Biol. 1992. PMID: 1639852 Free PMC article.
Integrin distributions in renal cell carcinomas of various grades of malignancy.
Korhonen M, Laitinen L, Ylänne J, Koukoulis GK, Quaranta V, Juusela H, Gould VE, Virtanen I. Korhonen M, et al. Am J Pathol. 1992 Nov;141(5):1161-71. Am J Pathol. 1992. PMID: 1443050 Free PMC article.
Changing roles of cadherins and catenins during progression of squamous intraepithelial lesions in the uterine cervix.
de Boer CJ, van Dorst E, van Krieken H, Jansen-van Rhijn CM, Warnaar SO, Fleuren GJ, Litvinov SV. de Boer CJ, et al. Am J Pathol. 1999 Aug;155(2):505-15. doi: 10.1016/S0002-9440(10)65146-2. Am J Pathol. 1999. PMID: 10433943 Free PMC article.
E-cadherin homophilic ligation inhibits cell growth and epidermal growth factor receptor signaling independently of other cell interactions.
Perrais M, Chen X, Perez-Moreno M, Gumbiner BM. Perrais M, et al. Mol Biol Cell. 2007 Jun;18(6):2013-25. doi: 10.1091/mbc.e06-04-0348. Epub 2007 Mar 28. Mol Biol Cell. 2007. PMID: 17392517 Free PMC article.

References

1. Exp Cell Res. 1984 May;152(1):169-78 - PubMed
1. Biochim Biophys Acta. 1982 Dec 21;695(2):113-76 - PubMed
1. Proc Natl Acad Sci U S A. 1984 Jul;81(13):4222-6 - PubMed
1. Invasion Metastasis. 1984;4(3):160-70 - PubMed
1. Cancer Metastasis Rev. 1983;2(2):201-18 - PubMed

Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion - PubMed (original) (raw)