Association of class I major histocompatibility heavy and light chains induced by viral peptides - PubMed (original) (raw)
. 1989 Aug 10;340(6233):443-8.
doi: 10.1038/340443a0.
Affiliations
- PMID: 2666863
- DOI: 10.1038/340443a0
Association of class I major histocompatibility heavy and light chains induced by viral peptides
A Townsend et al. Nature. 1989.
Abstract
We describe a cell in which association of a major histocompatibility complex class I heavy chain with beta 2-microglobulin is induced by a peptide derived from influenza nucleoprotein. Association of antigenic peptides with the binding site of class I molecules may be required for correct folding of the heavy chain, association with beta 2-microglobulin and transport of the antigen-MHC complex to the cell surface.
Comment in
- Antigen presentation. Peptide feeding and cellular cookery.
Parham P. Parham P. Nature. 1990 Aug 30;346(6287):793-5. doi: 10.1038/346793a0. Nature. 1990. PMID: 2392148 No abstract available.
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