Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins - PubMed (original) (raw)
Review
. 1989 Jul 28;245(4916):371-8.
doi: 10.1126/science.2667136.
Affiliations
- PMID: 2667136
- DOI: 10.1126/science.2667136
Review
Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins
P J Mitchell et al. Science. 1989.
Abstract
The cloning of genes encoding mammalian DNA binding transcription factors for RNA polymerase II has provided the opportunity to analyze the structure and function of these proteins. This review summarizes recent studies that define structural domains for DNA binding and transcriptional activation functions in sequence-specific transcription factors. The mechanisms by which these factors may activate transcriptional initiation and by which they may be regulated to achieve differential gene expression are also discussed.
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