Backfill is a specific sign of axial spondyloarthritis seen on MRI - PubMed (original) (raw)
Observational Study
Backfill is a specific sign of axial spondyloarthritis seen on MRI
Zaiying Hu et al. Joint Bone Spine. 2016 Mar.
Abstract
Objectives: To summarize the characteristics of backfill in patients with axial spondyloarthritis (SpA) and patients with non-specific back pain (NSBP) and healthy controls, and to assess the value of backfill in diagnosing axial SpA.
Methods: Three readers blinded recorded backfill seen on T1SE MRI scans from 647 subjects: 297 patients with ankylosing spondylitis (AS), 126 patients with non-radiographic axial SpA (nr-axSpA), 147 patients with NSBP, and 77 healthy controls. The SPARCC SIJ Structural Score (SSS) method was used to assess backfill. The changes of backfill were evaluated by the follow-up MRI scans from 157 patients. We summarized the characteristics of backfill and calculated its sensitivity and specificity for diagnosing axial SpA.
Results: Backfill was recorded in 78.8% AS patients, 11.1% nr-axSpA patients, 1.8% patients with NSBP, and no healthy control. Backfill affected more frequently at ilium bone, lower half of sacroiliac joints in axial SpA (both P<0.05). The SSS score of backfill was much higher in axial SpA than in patients with NSBP (both P<0.01) and it did not correlate with demographics and BASDAI, BASFI, and CRP (all P>0.05). The score of backfill only positively correlated with symptom duration in AS (r=0.251, P<0.01) and in nr-axSpA (r=0.743, P<0.01) patients. Only 8.9% patients had the change of backfill in an average follow-up time of 1.09 years. Backfill had high specificity (0.98) and moderate sensitivity (0.59) for diagnosing axial SpA.
Conclusions: We summarized the characteristics of backfill and found that backfill is a specific sign of axial SpA seen on T1SE MRI.
Keywords: MRI; Spondyloarthritis.
Copyright © 2015. Published by Elsevier SAS.
Similar articles
- Magnetic Resonance Imaging of Lesions in the Sacroiliac Joints for Differentiation of Patients With Axial Spondyloarthritis From Control Subjects With or Without Pelvic or Buttock Pain: A Prospective, Cross-Sectional Study of 204 Participants.
Seven S, Østergaard M, Morsel-Carlsen L, Sørensen IJ, Bonde B, Thamsborg G, Lykkegaard JJ, Hendricks O, Jørgensen NR, Pedersen SJ. Seven S, et al. Arthritis Rheumatol. 2019 Dec;71(12):2034-2046. doi: 10.1002/art.41037. Epub 2019 Oct 29. Arthritis Rheumatol. 2019. PMID: 31309740 - Does spinal MRI add incremental diagnostic value to MRI of the sacroiliac joints alone in patients with non-radiographic axial spondyloarthritis?
Weber U, Zubler V, Zhao Z, Lambert RG, Chan SM, Pedersen SJ, Østergaard M, Rufibach K, Maksymowych WP. Weber U, et al. Ann Rheum Dis. 2015 Jun;74(6):985-92. doi: 10.1136/annrheumdis-2013-203887. Epub 2014 Jan 22. Ann Rheum Dis. 2015. PMID: 24451240 - Optimisation of rheumatology assessments - the actual situation in axial spondyloarthritis including ankylosing spondylitis.
Braun J, Kiltz U, Baraliakos X, van der Heijde D. Braun J, et al. Clin Exp Rheumatol. 2014 Sep-Oct;32(5 Suppl 85):S-96-104. Epub 2014 Oct 30. Clin Exp Rheumatol. 2014. PMID: 25365096 Review. - [Differential diagnosis of axial spondyloarthritis-axSpA mimics].
Braun J, Baraliakos X, Buehring B, Fruth M, Kiltz U. Braun J, et al. Z Rheumatol. 2019 Feb;78(1):31-42. doi: 10.1007/s00393-018-0557-8. Z Rheumatol. 2019. PMID: 30377767 Review. German.
Cited by
- New Bone Formation in Axial Spondyloarthritis: A Review.
Ulas ST, Deppe D, Ziegeler K, Diekhoff T. Ulas ST, et al. Rofo. 2024 Jun;196(6):550-559. doi: 10.1055/a-2193-1970. Epub 2023 Nov 9. Rofo. 2024. PMID: 37944938 Free PMC article. Review. - Recent advances in ankylosing spondylitis: understanding the disease and management.
Garcia-Montoya L, Gul H, Emery P. Garcia-Montoya L, et al. F1000Res. 2018 Sep 21;7:F1000 Faculty Rev-1512. doi: 10.12688/f1000research.14956.1. eCollection 2018. F1000Res. 2018. PMID: 30345001 Free PMC article. Review. - "Long-term MRI findings in Ankylosing spondylitis patients treated with TNF inhibitors for a decade".
Venetsanopoulou AI, Anagnostou NE, Tziortzioti Z, Zikou A, Astrakas L, Argyropoulou MI, Voulgari PV. Venetsanopoulou AI, et al. Rheumatol Int. 2024 Nov;44(11):2583-2589. doi: 10.1007/s00296-023-05530-z. Epub 2024 Jan 31. Rheumatol Int. 2024. PMID: 38294543 - [Long version on the S3 guidelines for axial spondyloarthritis including Bechterew's disease and early forms, Update 2019 : Evidence-based guidelines of the German Society for Rheumatology (DGRh) and participating medical scientific specialist societies and other organizations].
Kiltz U, Braun J; DGRh; Becker A; DEGAM; Chenot JF, Dreimann M; DWG; Hammel L; DVMB; Heiligenhaus A; DOG; Hermann KG; DRG; Klett R; DGMM; Krause D, Kreitner KF, Lange U; DGPMR/DGRW; Lauterbach A; Physio Deutschland; Mau W, Mössner R; DDG; Oberschelp U; DGOOC; Philipp S, Pleyer U, Rudwaleit M, Schneider E, Schulte TL, Sieper J, Stallmach A; DGIM; Swoboda B; DGOOC/DGORh; Winking M; DGNC. Kiltz U, et al. Z Rheumatol. 2019 Dec;78(Suppl 1):3-64. doi: 10.1007/s00393-019-0670-3. Z Rheumatol. 2019. PMID: 31784900 German. No abstract available.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
Miscellaneous