Translational blockade imposed by cytokine-derived UA-rich sequences - PubMed (original) (raw)

. 1989 Aug 25;245(4920):852-5.

doi: 10.1126/science.2672333.

Affiliations

• PMID: 2672333
• DOI: 10.1126/science.2672333

Translational blockade imposed by cytokine-derived UA-rich sequences

V Kruys et al. Science. 1989.

Abstract

The messenger RNAs specifying certain proteins involved in the inflammatory response and certain oncoproteins contain a conserved UA-rich sequence in the 3' untranslated region. This sequence, which is composed of several interspersed repeats of the octanucleotide UUAUUUAU, has been shown to destabilize mRNA in some eukaryotes. However, this effect is not seen when mRNAs are transferred to Xenopus oocytes, which made it possible to separate stability from translational regulation. For interferon, granulocyte-macrophage colony-stimulating factor, and c-fos RNAs, the UA-rich sequence was observed to preclude mRNA translation.

PubMed Disclaimer

Similar articles

• Translational control mediated by UA-rich sequences.
  Kruys V, Beutler B, Huez G. Kruys V, et al. Enzyme. 1990;44(1-4):193-202. doi: 10.1159/000468757. Enzyme. 1990. PMID: 2133651 Review.
• Identification of a translation inhibitory element (TIE) in the 3' untranslated region of the human interferon-beta mRNA.
  Kruys VI, Wathelet MG, Huez GA. Kruys VI, et al. Gene. 1988 Dec 10;72(1-2):191-200. doi: 10.1016/0378-1119(88)90144-8. Gene. 1988. PMID: 3243431
• An mRNA sharing sequences with a variant granulocyte-macrophage colony stimulating factor cDNA clone.
  Gough NM, King JA, Dunn AR. Gough NM, et al. Nucleic Acids Res. 1987 Dec 23;15(24):10584. doi: 10.1093/nar/15.24.10584. Nucleic Acids Res. 1987. PMID: 3320970 Free PMC article. No abstract available.
• Translational control of cytokine expression by 3' UA-rich sequences.
  Kruys V, Huez G. Kruys V, et al. Biochimie. 1994;76(9):862-6. doi: 10.1016/0300-9084(94)90188-0. Biochimie. 1994. PMID: 7880903 Review.
• GM-CSF and oncogene mRNA stabilities are independently regulated in trans in a mouse monocytic tumor.
  Schuler GD, Cole MD. Schuler GD, et al. Cell. 1988 Dec 23;55(6):1115-22. doi: 10.1016/0092-8674(88)90256-5. Cell. 1988. PMID: 3060261

Cited by

• Effects of Combinations of Untranslated-Region Sequences on Translation of mRNA.
  Kirshina A, Vasileva O, Kunyk D, Seregina K, Muslimov A, Ivanov R, Reshetnikov V. Kirshina A, et al. Biomolecules. 2023 Nov 20;13(11):1677. doi: 10.3390/biom13111677. Biomolecules. 2023. PMID: 38002359 Free PMC article.
• Alternative polyadenylation regulates acetyl-CoA carboxylase function in peanut.
  Peng Z, Yu S, Meng J, Jia KH, Zhang J, Li X, Gao W, Wan S. Peng Z, et al. BMC Genomics. 2023 Oct 24;24(1):637. doi: 10.1186/s12864-023-09696-5. BMC Genomics. 2023. PMID: 37875812 Free PMC article.
• Alternative 3'-untranslated regions regulate high-salt tolerance of Spartina alterniflora.
  Wang T, Ye W, Zhang J, Li H, Zeng W, Zhu S, Ji G, Wu X, Ma L. Wang T, et al. Plant Physiol. 2023 Apr 3;191(4):2570-2587. doi: 10.1093/plphys/kiad030. Plant Physiol. 2023. PMID: 36682816 Free PMC article.
• Modulation of surface CD11c expression tracks plasticity in murine intestinal tissue eosinophils.
  Larsen LD, Dockstader K, Olbrich CL, Cartwright IM, Spencer LA. Larsen LD, et al. J Leukoc Biol. 2022 May;111(5):943-952. doi: 10.1002/JLB.3HI0821-432RR. Epub 2022 Feb 9. J Leukoc Biol. 2022. PMID: 35141942 Free PMC article.
• Metabolic Messengers: tumour necrosis factor.
  Sethi JK, Hotamisligil GS. Sethi JK, et al. Nat Metab. 2021 Oct;3(10):1302-1312. doi: 10.1038/s42255-021-00470-z. Epub 2021 Oct 14. Nat Metab. 2021. PMID: 34650277 Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon