N-ras mutations in human cutaneous melanoma from sun-exposed body sites - PubMed (original) (raw)
N-ras mutations in human cutaneous melanoma from sun-exposed body sites
L J van 't Veer et al. Mol Cell Biol. 1989 Jul.
Abstract
In 7 of 37 patients with cutaneous melanoma, mutations in the N-ras gene were found. The primary tumors of these seven patients were exclusively localized on body sites continuously exposed to sunlight. Moreover, the ras mutations were all at or near dipyrimidine sites known to be targets of UV damage. Two primary tumors were biclonal with respect to ras mutation. An active role for UV irradiation in induction of the mutations is suggested.
Similar articles
- p53 mutations in human cutaneous melanoma correlate with sun exposure but are not always involved in melanomagenesis.
Zerp SF, van Elsas A, Peltenburg LT, Schrier PI. Zerp SF, et al. Br J Cancer. 1999 Feb;79(5-6):921-6. doi: 10.1038/sj.bjc.6690147. Br J Cancer. 1999. PMID: 10070891 Free PMC article. - Relevance of ultraviolet-induced N-ras oncogene point mutations in development of primary human cutaneous melanoma.
van Elsas A, Zerp SF, van der Flier S, Krüse KM, Aarnoudse C, Hayward NK, Ruiter DJ, Schrier PI. van Elsas A, et al. Am J Pathol. 1996 Sep;149(3):883-93. Am J Pathol. 1996. PMID: 8780392 Free PMC article. - Prognostic implications of p53 overexpression in cutaneous melanoma from sun-exposed and nonexposed sites.
Essner R, Kuo CT, Wang H, Wen DR, Turner RR, Nguyen T, Hoon DS. Essner R, et al. Cancer. 1998 Jan 15;82(2):309-16. doi: 10.1002/(sici)1097-0142(19980115)82:2<317::aid-cncr10>3.0.co;2-1. Cancer. 1998. PMID: 9445187 - Activated ras. Yet another player in melanoma?
Herlyn M, Satyamoorthy K. Herlyn M, et al. Am J Pathol. 1996 Sep;149(3):739-44. Am J Pathol. 1996. PMID: 8780377 Free PMC article. Review. No abstract available. - UV-induced N-ras mutations are T-cell targets in human melanoma.
van Elsas A, Scheibenbogen C, van der Minne C, Zerp SF, Keilholz U, Schrier PI. van Elsas A, et al. Melanoma Res. 1997 Aug;7 Suppl 2:S107-13. Melanoma Res. 1997. PMID: 9578425 Review.
Cited by
- What are we learning from the cancer genome?
Collisson EA, Cho RJ, Gray JW. Collisson EA, et al. Nat Rev Clin Oncol. 2012 Nov;9(11):621-30. doi: 10.1038/nrclinonc.2012.159. Epub 2012 Sep 11. Nat Rev Clin Oncol. 2012. PMID: 22965149 Free PMC article. Review. - BRAF in Melanoma: Pathogenesis, Diagnosis, Inhibition, and Resistance.
Sullivan RJ, Flaherty KT. Sullivan RJ, et al. J Skin Cancer. 2011;2011:423239. doi: 10.1155/2011/423239. Epub 2011 Nov 17. J Skin Cancer. 2011. PMID: 22175026 Free PMC article. - Molecular testing in melanoma.
Wilson MA, Nathanson KL. Wilson MA, et al. Cancer J. 2012 Mar-Apr;18(2):117-23. doi: 10.1097/PPO.0b013e31824f11bf. Cancer J. 2012. PMID: 22453011 Free PMC article. Review. - Human cutaneous melanoma; a review of NRAS and BRAF mutation frequencies in relation to histogenetic subclass and body site.
Platz A, Egyhazi S, Ringborg U, Hansson J. Platz A, et al. Mol Oncol. 2008 Apr;1(4):395-405. doi: 10.1016/j.molonc.2007.12.003. Epub 2007 Dec 28. Mol Oncol. 2008. PMID: 19383313 Free PMC article. - Naturally Occurring Canine Melanoma as a Predictive Comparative Oncology Model for Human Mucosal and Other Triple Wild-Type Melanomas.
Hernandez B, Adissu HA, Wei BR, Michael HT, Merlino G, Simpson RM. Hernandez B, et al. Int J Mol Sci. 2018 Jan 30;19(2):394. doi: 10.3390/ijms19020394. Int J Mol Sci. 2018. PMID: 29385676 Free PMC article. Review.
References
- Nature. 1984 Mar 1-7;308(5954):69-72 - PubMed
- J Mol Biol. 1989 Jan 5;205(1):103-13 - PubMed
- Int J Cancer. 1985 Apr 15;35(4):427-33 - PubMed
- Mol Cell Biol. 1985 Mar;5(3):582-5 - PubMed
- J Mol Biol. 1985 Mar 5;182(1):45-65 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous