Interleukin 33 is a guardian of barriers and a local alarmin - PubMed (original) (raw)

Review

doi: 10.1038/ni.3370.

Affiliations

Review

Interleukin 33 is a guardian of barriers and a local alarmin

Nikolas T Martin et al. Nat Immunol. 2016 Feb.

Abstract

Interleukin 33 (IL-33) is a member of the IL-1 family of cytokines with a growing number of target cells and a plethora of biological functions. Although it has commonalities with other IL-1 cytokines, IL-33 exhibits some unique features. Here we review the biology of IL-33 and its receptor and develop a working model that describes two 'lives' for IL-33-one intracellular and one extracellular. Under healthy conditions, constitutively produced, intracellular IL-33 participates in maintaining barrier function by regulating gene expression as a nuclear protein. In parallel, nuclear IL-33 functions as a stored alarmin that is released when barriers are breached. Extracellular IL-33 coordinates immune defense and repair mechanisms while also initiating differentiation of helper T cells as the adaptive immune response is triggered.

PubMed Disclaimer

References

    1. Int J Biochem Cell Biol. 2011 Sep;43(9):1383-91 -PubMed
    1. J Mol Cell Cardiol. 2013 Jul;60:16-26 -PubMed
    1. Arthritis Rheum. 2009 Mar;60(3):738-49 -PubMed
    1. Immunity. 2013 Dec 12;39(6):1003-18 -PubMed
    1. J Allergy Clin Immunol. 2012 Jan;129(1):216-27.e1-6 -PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources