Altered Local Spontaneous Brain Activity in Juvenile Myoclonic Epilepsy: A Preliminary Resting-State fMRI Study - PubMed (original) (raw)

Altered Local Spontaneous Brain Activity in Juvenile Myoclonic Epilepsy: A Preliminary Resting-State fMRI Study

Sisi Jiang et al. Neural Plast. 2016.

Abstract

Purpose. The purpose of this study was to evaluate the regional synchronization of brain in patients with juvenile myoclonic epilepsy (JME). Methods. Resting-state fMRI data were acquired from twenty-one patients with JME and twenty-two healthy subjects. Regional homogeneity (ReHo) was used to analyze the spontaneous activity in whole brain. Two-sample t-test was performed to detect the ReHo difference between two groups. Correlations between the ReHo values and features of seizures were calculated further. Key Findings. Compared with healthy controls, patients showed significantly increased ReHo in bilateral thalami and motor-related cortex regions and a substantial reduction of ReHo in cerebellum and occipitoparietal lobe. In addition, greater ReHo value in the left paracentral lobule was linked to the older age of onset in patients. Significance. These findings implicated the abnormality of thalamomotor cortical network in JME which were associated with the genesis and propagation of epileptiform activity. Moreover, our study supported that the local brain spontaneous activity is a potential tool to investigate the epileptic activity and provided important insights into understanding the pathophysiological mechanisms of JME.

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Figures

Figure 1

Figure 1

The ReHo results for patients with JME and healthy controls. The T values of one-sample _t_-test were showed in each group, respectively. HC: healthy control group.

Figure 2

Figure 2

Statistic t-map showing the difference between the JME group and healthy control (two-sample _t_-test, P < 0.05 with FDR correction). The _T_ scores were showed with hot color for positive values (JME > healthy controls) and cool colors for negative values (JME < healthy controls).

Figure 3

Figure 3

The relation between ReHo value in left paracentral lobule and age at onset in patients with JME. +: the coordinate value implicates the residuals after controlling for the influence of the gender and age (linear regression with covariates including gender and age).

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