Human chromosome 12 is required for elevated HIV-1 expression in human-hamster hybrid cells - PubMed (original) (raw)
. 1989 Oct 27;246(4929):488-91.
doi: 10.1126/science.2683071.
Affiliations
- PMID: 2683071
- DOI: 10.1126/science.2683071
Human chromosome 12 is required for elevated HIV-1 expression in human-hamster hybrid cells
C E Hart et al. Science. 1989.
Abstract
Host cell factors act together with regulatory genes of the human immunodeficiency virus (HIV) to control virus production. Human-Chinese hamster ovary hybrid cell clones were used to probe for human chromosomes involved in regulating HIV gene expression. DNA transfection experiments showed that 4 of 18 clones had high levels of HIV gene expression measured by both extracellular virus production and transactivation of the HIV long terminal repeat in the presence of the trans-activator (tat) gene. Karyotype analyses revealed a 94% concordance (17/18) between human chromosome 12 and HIV gene expression. Other chromosomes had an 11 to 72% concordance with virus production.
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