Suppression of MHC class I RNA in highly oncogenic cells occurs at the level of transcription initiation - PubMed (original) (raw)
Comparative Study
. 1989 Dec 1;143(11):3792-7.
Affiliations
- PMID: 2685121
Comparative Study
Suppression of MHC class I RNA in highly oncogenic cells occurs at the level of transcription initiation
N Lassam et al. J Immunol. 1989.
Abstract
The oncogenic potential of some transformed cell lines has been shown in animal tumor models to be the direct result of MHC class I mRNA suppression. Rodent cells established with the highly oncogenic human adenovirus type 12 exhibit greatly reduced levels of class I Ag compared with cells derived with the nononcogenic adenovirus type 5. By using seven independently derived adenovirus-transformed cell lines, we have investigated the mechanism responsible for down-regulation of class I RNA expression. In all adenovirus 12-transformed cells examined, class I RNA suppression was the result of a block in transcription initiation. Highly oncogenic cell lines derived from a spontaneous melanoma and a chemically induced sarcoma also showed greatly reduced transcription of class I genes. We conclude that suppression of MHC class I RNA in a variety of highly oncogenic cells results largely from a substantial decrease in transcription initiation.
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