The Reciprocal Interactions between Polyphenols and Gut Microbiota and Effects on Bioaccessibility - PubMed (original) (raw)

Review

The Reciprocal Interactions between Polyphenols and Gut Microbiota and Effects on Bioaccessibility

Tugba Ozdal et al. Nutrients. 2016.

Abstract

As of late, polyphenols have increasingly interested the scientific community due to their proposed health benefits. Much of this attention has focused on their bioavailability. Polyphenol-gut microbiota interactions should be considered to understand their biological functions. The dichotomy between the biotransformation of polyphenols into their metabolites by gut microbiota and the modulation of gut microbiota composition by polyphenols contributes to positive health outcomes. Although there are many studies on the in vivo bioavailability of polyphenols, the mutual relationship between polyphenols and gut microbiota is not fully understood. This review focuses on the biotransformation of polyphenols by gut microbiota, modulation of gut microbiota by polyphenols, and the effects of these two-way mutual interactions on polyphenol bioavailability, and ultimately, human health.

Keywords: bioavailability; flavonoids; gut microbiota; health; interactions; microbial metabolism; phenolics; polyphenols.

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Figures

Figure 1

Microbiota heterocyclic C ring cleavage of flavonoids; (|||) positions of the potential C-ring cleavages [42].

Figure 2

Nonflavonoid-type phenolics that are metabolized by the gut microbiota [42].

Figure 3

Absorption and metabolism of flavone _C_-monoglycosides (blue arrow) and _C_-multiglycosides (red arrow) [63].

Figure 4

pH-dependent structural changes and degradation of cyanidin-3-glucoside. Reproduced from the original source [94].

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The Reciprocal Interactions between Polyphenols and Gut Microbiota and Effects on Bioaccessibility - PubMed (original) (raw)