Atherosclerosis: Successes, Surprises, and Future Challenges - PubMed (original) (raw)

Editorial

Atherosclerosis: Successes, Surprises, and Future Challenges

Peter Libby et al. Circ Res. 2016.

No abstract available

Keywords: Editorials; atherosclerosis; clinical trial; endothelial cells; epidemiology; leukocytes; pharmacology; smooth muscle cells; vascular cell biology.

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Figures

Figure 1

Figure 1. Interplay among processes associated with increased cardiovascular disease risk and treatment strategies targeting these processes

The review articles included in this compendium provide a comprehensive overview of the state of the atherosclerosis research area today and some of its history. Recent progress has advanced three major areas related to atherosclerosis and cardiovascular risk: the roles of lipoproteins (LDL, TG-rich remnant lipoproteins and HDL); identification of genes associated with cardiovascular disease risk through GWAS; and further elucidation of local processes in the artery wall. These three areas exhibit significant overlap as demonstrated by the Venn diagram. Treatment strategies targeting lipoproteins and several of the genes identified by GWAS include statins and the recently approved PCSK9 inhibitors. Anti-inflammatory agents might target inflammatory genes identified by GWAS. Anti-inflammatory agents, as well as anti-hypertensive agents may also modulate atherogenic processes locally in the artery wall.

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