How are substrates recognized by the ubiquitin-mediated proteolytic system? - PubMed (original) (raw)
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How are substrates recognized by the ubiquitin-mediated proteolytic system?
A Ciechanover et al. Trends Biochem Sci. 1989 Dec.
Abstract
A necessary step in the degradation of proteins by the ubiquitin system is recognition by the ubiquitin-protein ligases(s). Various structural features of the proteolytic substrate render it susceptible to conjugation with ubiquitin. The N-terminal residue plays a major role in this process, with distinct sites on the ligase(s) recognizing specific types of N-termini. Post-translational modification of some of these residues is required prior to their recognition. A free N terminus is not the only marker; proteins with either free or blocked N termini can be recognized via structural domains that are downstream and distinct from this residue.
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