Molecular and Epigenetic Mechanism Regulating Hypothalamic Kiss1 Gene Expression in Mammals - PubMed (original) (raw)

Review

doi: 10.1159/000445207. Epub 2016 Mar 11.

Junko Tomikawa, Naoko Inoue, Teppei Goto, Shiori Minabe, Nahoko Ieda, Sho Nakamura, Youki Watanabe, Kana Ikegami, Fuko Matsuda, Satoshi Ohkura, Kei-Ichiro Maeda, Hiroko Tsukamura

Affiliations

• PMID: 26964105
• DOI: 10.1159/000445207

Free article

Review

Molecular and Epigenetic Mechanism Regulating Hypothalamic Kiss1 Gene Expression in Mammals

Yoshihisa Uenoyama et al. Neuroendocrinology. 2016.

Free article

Abstract

After the discovery of hypothalamic kisspeptin encoded by the Kiss1 gene, the central mechanism regulating gonadotropin-releasing hormone (GnRH) secretion, and hence gonadotropin secretion, is gradually being unraveled. This has increased our understanding of the central mechanism regulating puberty and subsequent reproductive performance in mammals. Recently, emerging evidence has indicated the molecular and epigenetic mechanism regulating hypothalamic Kiss1 gene expression. Here we compile data regarding DNA and histone modifications in the Kiss1 promoter region and provide a hypothetic scheme of the molecular and epigenetic mechanism regulating Kiss1 gene expression in two populations of hypothalamic kisspeptin neurons, which govern puberty and subsequent reproductive performance via GnRH/gonadotropin secretion.

© 2016 S. Karger AG, Basel.

PubMed Disclaimer

Similar articles

• The roles of kisspeptin revisited: inside and outside the hypothalamus.
  Uenoyama Y, Pheng V, Tsukamura H, Maeda KI. Uenoyama Y, et al. J Reprod Dev. 2016 Dec 20;62(6):537-545. doi: 10.1262/jrd.2016-083. Epub 2016 Jul 29. J Reprod Dev. 2016. PMID: 27478063 Free PMC article. Review.
• The roles of kisspeptin in the mechanism underlying reproductive functions in mammals.
  Uenoyama Y, Inoue N, Maeda KI, Tsukamura H. Uenoyama Y, et al. J Reprod Dev. 2018 Dec 14;64(6):469-476. doi: 10.1262/jrd.2018-110. Epub 2018 Oct 8. J Reprod Dev. 2018. PMID: 30298825 Free PMC article. Review.
• Epigenetic regulation of Kiss1 gene expression mediating estrogen-positive feedback action in the mouse brain.
  Tomikawa J, Uenoyama Y, Ozawa M, Fukanuma T, Takase K, Goto T, Abe H, Ieda N, Minabe S, Deura C, Inoue N, Sanbo M, Tomita K, Hirabayashi M, Tanaka S, Imamura T, Okamura H, Maeda K, Tsukamura H. Tomikawa J, et al. Proc Natl Acad Sci U S A. 2012 May 15;109(20):E1294-301. doi: 10.1073/pnas.1114245109. Epub 2012 Apr 13. Proc Natl Acad Sci U S A. 2012. PMID: 22505735 Free PMC article.
• Kisspeptins modulate the biology of multiple populations of gonadotropin-releasing hormone neurons during embryogenesis and adulthood in zebrafish (Danio rerio).
  Zhao Y, Lin MC, Mock A, Yang M, Wayne NL. Zhao Y, et al. PLoS One. 2014 Aug 5;9(8):e104330. doi: 10.1371/journal.pone.0104330. eCollection 2014. PLoS One. 2014. PMID: 25093675 Free PMC article.
• Sex steroids and the control of the Kiss1 system: developmental roles and major regulatory actions.
  García-Galiano D, Pinilla L, Tena-Sempere M. García-Galiano D, et al. J Neuroendocrinol. 2012 Jan;24(1):22-33. doi: 10.1111/j.1365-2826.2011.02230.x. J Neuroendocrinol. 2012. PMID: 21951227 Review.

Cited by

• DNA hypermethylation of Kiss1r promoter and reduction of hepatic Kiss1r in female rats with type 2 diabetes.
  Ziarniak K, Yang T, Boycott C, Beetch M, Sassek M, Grzeda E, Ma Y, Sliwowska JH, Stefanska B. Ziarniak K, et al. Epigenetics. 2022 Dec;17(13):2332-2346. doi: 10.1080/15592294.2022.2119120. Epub 2022 Sep 12. Epigenetics. 2022. PMID: 36094166 Free PMC article.
• The role of Kisspeptin signaling in Oocyte maturation.
  Masumi S, Lee EB, Dilower I, Upadhyaya S, Chakravarthi VP, Fields PE, Rumi MAK. Masumi S, et al. Front Endocrinol (Lausanne). 2022 Aug 22;13:917464. doi: 10.3389/fendo.2022.917464. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 36072937 Free PMC article. Review.
• Sexual Dimorphism in Kisspeptin Signaling.
  Lee EB, Dilower I, Marsh CA, Wolfe MW, Masumi S, Upadhyaya S, Rumi MAK. Lee EB, et al. Cells. 2022 Mar 28;11(7):1146. doi: 10.3390/cells11071146. Cells. 2022. PMID: 35406710 Free PMC article. Review.
• Epigenomics and gene regulation in mammalian social systems.
  Guerrero TP, Fickel J, Benhaiem S, Weyrich A. Guerrero TP, et al. Curr Zool. 2020 Jun;66(3):307-319. doi: 10.1093/cz/zoaa005. Epub 2020 Feb 25. Curr Zool. 2020. PMID: 32440291 Free PMC article.
• Metabolic regulation of kisspeptin - the link between energy balance and reproduction.
  Navarro VM. Navarro VM. Nat Rev Endocrinol. 2020 Aug;16(8):407-420. doi: 10.1038/s41574-020-0363-7. Epub 2020 May 19. Nat Rev Endocrinol. 2020. PMID: 32427949 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Ovid Technologies, Inc.
  • S. Karger AG, Basel, Switzerland

• Other Literature Sources

  • scite Smart Citations