Strategies to enhance rational use of antibiotics in hospital: a guideline by the German Society for Infectious Diseases - PubMed (original) (raw)

. 2016 Jun;44(3):395-439.

doi: 10.1007/s15010-016-0885-z.

F Allerberger 2, S Amann 3, P Apfalter 4, H-R Brodt 5, T Eckmanns 6, M Fellhauer 7, H K Geiss 8, O Janata 9, R Krause 10, S Lemmen 11, E Meyer 12, H Mittermayer 4, U Porsche 13, E Presterl 14, S Reuter 15, B Sinha 16, R Strauß 17, A Wechsler-Fördös 18, C Wenisch 19, W V Kern 20

Affiliations

Strategies to enhance rational use of antibiotics in hospital: a guideline by the German Society for Infectious Diseases

K de With et al. Infection. 2016 Jun.

Abstract

Introduction: In the time of increasing resistance and paucity of new drug development there is a growing need for strategies to enhance rational use of antibiotics in German and Austrian hospitals. An evidence-based guideline on recommendations for implementation of antibiotic stewardship (ABS) programmes was developed by the German Society for Infectious Diseases in association with the following societies, associations and institutions: German Society of Hospital Pharmacists, German Society for Hygiene and Microbiology, Paul Ehrlich Society for Chemotherapy, The Austrian Association of Hospital Pharmacists, Austrian Society for Infectious Diseases and Tropical Medicine, Austrian Society for Antimicrobial Chemotherapy, Robert Koch Institute.

Materials and methods: A structured literature research was performed in the databases EMBASE, BIOSIS, MEDLINE and The Cochrane Library from January 2006 to November 2010 with an update to April 2012 (MEDLINE and The Cochrane Library). The grading of recommendations in relation to their evidence is according to the AWMF Guidance Manual and Rules for Guideline Development.

Conclusion: The guideline provides the grounds for rational use of antibiotics in hospital to counteract antimicrobial resistance and to improve the quality of care of patients with infections by maximising clinical outcomes while minimising toxicity. Requirements for a successful implementation of ABS programmes as well as core and supplemental ABS strategies are outlined. The German version of the guideline was published by the German Association of the Scientific Medical Societies (AWMF) in December 2013.

Keywords: ABS; Antibiotic stewardship; Antimicrobial resistance; Guideline; Quality of care; Rational use.

PubMed Disclaimer

Figures

Fig. 1

Fig. 1

Graphical presentation of quarterly use density (RDD/100 patient-days) for different antibiotic classes

Comment in

Similar articles

Cited by

References

    1. MacDougall C, Polk RE. Antimicrobial stewardship programs in health care systems. Clin Microbiol Rev. 2005;18:638–656. doi: 10.1128/CMR.18.4.638-656.2005. - DOI - PMC - PubMed
    1. Davey P, Brown E, Fenelon L, et al. Interventions to improve antibiotic prescribing practices for hospital inpatients. Cochrane Database Syst Rev. 2005;4:CD003543. - PubMed
    1. Paterson DL. The role of antimicrobial management programs in optimizing antibiotic prescribing within hospitals. Clin Infect Dis. 2006;42:S90–S95. doi: 10.1086/499407. - DOI - PubMed
    1. Fishman N. Antimicrobial stewardship. Am J Infect Control. 2006;34:S55–S63. doi: 10.1016/j.ajic.2006.05.237. - DOI - PubMed
    1. Fishman N. Antimicrobial stewardship. Am J Med. 2006;119:S53–S61. doi: 10.1016/j.amjmed.2006.04.003. - DOI - PubMed

MeSH terms

Substances

LinkOut - more resources