Long Noncoding RNAs in Cancer Pathways - PubMed (original) (raw)
Review
Long Noncoding RNAs in Cancer Pathways
Adam M Schmitt et al. Cancer Cell. 2016.
Abstract
Genome-wide cancer mutation analyses are revealing an extensive landscape of functional mutations within the noncoding genome, with profound effects on the expression of long noncoding RNAs (lncRNAs). While the exquisite regulation of lncRNA transcription can provide signals of malignant transformation, we now understand that lncRNAs drive many important cancer phenotypes through their interactions with other cellular macromolecules including DNA, protein, and RNA. Recent advancements in surveying lncRNA molecular mechanisms are now providing the tools to functionally annotate these cancer-associated transcripts, making these molecules attractive targets for therapeutic intervention in the fight against cancer.
Copyright © 2016 Elsevier Inc. All rights reserved.
Figures
Figure 1. LncRNA mechanisms rely on interactions with cellular macromolecules
(A) Chromatin bound lncRNAs can regulate gene expression by controlling local chromatin architecture (above) or directing the recruitment of regulatory molecules to specific loci (below). (B) LncRNA interactions with multiple proteins can promote the assembly of protein complexes (above), or impair protein-protein interactions (below). (C) mRNA interactions with lncRNA can recruit protein machinery involved in multiple aspects of mRNA metabolism to affect splicing, mRNA stability, or translation (above) or sequester miRNA away from target mRNA (below).
Figure 2. LncRNAs in Cancer Phenotypes
LncRNAs contribute to each of the six hallmarks of cancer (diagram adapted from Hanahan and Weinberg, 2000). Selected examples of lncRNAs and their molecular partners or genomic targets are shown for proliferation, growth suppression, motility, immortality, angiogenesis, and viability cancer phenotypes.
Similar articles
- Integrative genomic analyses reveal clinically relevant long noncoding RNAs in human cancer.
Du Z, Fei T, Verhaak RG, Su Z, Zhang Y, Brown M, Chen Y, Liu XS. Du Z, et al. Nat Struct Mol Biol. 2013 Jul;20(7):908-13. doi: 10.1038/nsmb.2591. Epub 2013 Jun 2. Nat Struct Mol Biol. 2013. PMID: 23728290 Free PMC article. - Roles and Regulation of Long Noncoding RNAs in Hepatocellular Carcinoma.
Lim LJ, Wong SYS, Huang F, Lim S, Chong SS, Ooi LL, Kon OL, Lee CG. Lim LJ, et al. Cancer Res. 2019 Oct 15;79(20):5131-5139. doi: 10.1158/0008-5472.CAN-19-0255. Epub 2019 Jul 23. Cancer Res. 2019. PMID: 31337653 Review. - A novel antisense lncRNA NT5E promotes progression by modulating the expression of SYNCRIP and predicts a poor prognosis in pancreatic cancer.
Zhang P, Cao M, Zhang Y, Xu L, Meng F, Wu X, Xia T, Chen Q, Shi G, Wu P, Chen L, Lu Z, Yin J, Cai B, Cao S, Miao Y, Jiang K. Zhang P, et al. J Cell Mol Med. 2020 Sep;24(18):10898-10912. doi: 10.1111/jcmm.15718. Epub 2020 Aug 8. J Cell Mol Med. 2020. PMID: 32770626 Free PMC article. - From junk to master regulators of invasion: lncRNA functions in migration, EMT and metastasis.
Dhamija S, Diederichs S. Dhamija S, et al. Int J Cancer. 2016 Jul 15;139(2):269-80. doi: 10.1002/ijc.30039. Epub 2016 Mar 2. Int J Cancer. 2016. PMID: 26875870 Review. - Long noncoding RNAs in cancer cells.
Bach DH, Lee SK. Bach DH, et al. Cancer Lett. 2018 Apr 10;419:152-166. doi: 10.1016/j.canlet.2018.01.053. Cancer Lett. 2018. PMID: 29414303 Review.
Cited by
- Non-coding RNAs as a Critical Player in the Regulation of Inflammasome in Inflammatory Bowel Diseases; Emphasize on lncRNAs.
Salim Abed H, Oghenemaro EF, Kubaev A, Jeddoa ZMA, S R, Sharma S, Vashishth R, Jabir MS, Jawad SF, Zwamel AH. Salim Abed H, et al. Cell Biochem Biophys. 2024 Oct 19. doi: 10.1007/s12013-024-01585-2. Online ahead of print. Cell Biochem Biophys. 2024. PMID: 39424765 Review. - Functional Bidirectionality of ERV-Derived Long Non-Coding RNAs in Humans.
Song Y, Wen H, Zhai X, Jia L, Li L. Song Y, et al. Int J Mol Sci. 2024 Sep 29;25(19):10481. doi: 10.3390/ijms251910481. Int J Mol Sci. 2024. PMID: 39408810 Free PMC article. Review. - Competing endogenous RNAs (ceRNAs) and drug resistance to cancer therapy.
To KKW, Zhang H, Cho WC. To KKW, et al. Cancer Drug Resist. 2024 Sep 25;7:37. doi: 10.20517/cdr.2024.66. eCollection 2024. Cancer Drug Resist. 2024. PMID: 39403602 Free PMC article. Review. - Ferroptosis-associated genes and compounds in renal cell carcinoma.
He C, Li Q, Wu W, Liu K, Li X, Zheng H, Lai Y. He C, et al. Front Immunol. 2024 Sep 27;15:1473203. doi: 10.3389/fimmu.2024.1473203. eCollection 2024. Front Immunol. 2024. PMID: 39399506 Free PMC article. Review. - Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects.
Ru Q, Li Y, Chen L, Wu Y, Min J, Wang F. Ru Q, et al. Signal Transduct Target Ther. 2024 Oct 14;9(1):271. doi: 10.1038/s41392-024-01969-z. Signal Transduct Target Ther. 2024. PMID: 39396974 Free PMC article. Review.
References
- Arab K, Park YJ, Lindroth AM, Schafer A, Oakes C, Weichenhan D, Lukanova A, Lundin E, Risch A, Meister M, et al. Long noncoding RNA TARID directs demethylation and activation of the tumor suppressor TCF21 via GADD45A. Molecular cell. 2014;55:604–614. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
- R01-ES023168/ES/NIEHS NIH HHS/United States
- P30 CA008748/CA/NCI NIH HHS/United States
- R01-CA118750/CA/NCI NIH HHS/United States
- R01 ES023168/ES/NIEHS NIH HHS/United States
- R01 CA118750/CA/NCI NIH HHS/United States
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases