Treatment Approach to Patients With Severe Insulin Resistance - PubMed (original) (raw)
Treatment Approach to Patients With Severe Insulin Resistance
Timothy J Church et al. Clin Diabetes. 2016 Apr.
Erratum in
- Erratum: Church TJ, Haines ST. Treatment Approaches to Patients With Severe Insulin Resistance. Clinical Diabetes 2016;34:97-104 (DOI:10.2337/diaclin.34.2.97).
[No authors listed] [No authors listed] Clin Diabetes. 2016 Jul;34(3):168. doi: 10.2337/diaclin.34.3.168. Clin Diabetes. 2016. PMID: 27621536 Free PMC article.
Abstract
In Brief Patients with severe insulin resistance require >2 units/kg of body weight or 200 units/day of insulin. Yet, many patients do not achieve glycemic targets despite using very high doses of insulin. Insulin can cause weight gain, which further contributes to worsening insulin resistance. This article describes the pharmacological options for managing patients with severe insulin resistance, including the use of U-500 insulin and newer agents in combination with insulin.
Figures
FIGURE 1.
U-500 regular insulin initial dosing recommendations (6,55).
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