Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes - PubMed (original) (raw)

. 2016 Apr 22;352(6284):459-63.

doi: 10.1126/science.aad2035.

Martina Minnich 2, Natasja A M Kragten 3, Yang Liao 4, Benjamin Nota 5, Cyril Seillet 4, Ali Zaid 6, Kevin Man 4, Simon Preston 4, David Freestone 6, Asolina Braun 6, Erica Wynne-Jones 6, Felix M Behr 7, Regina Stark 3, Daniel G Pellicci 8, Dale I Godfrey 8, Gabrielle T Belz 4, Marc Pellegrini 4, Thomas Gebhardt 6, Meinrad Busslinger 2, Wei Shi 9, Francis R Carbone 6, René A W van Lier 3, Axel Kallies 10, Klaas P J M van Gisbergen 11

Affiliations

Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes

Laura K Mackay et al. Science. 2016.

Abstract

Tissue-resident memory T (Trm) cells permanently localize to portals of pathogen entry, where they provide immediate protection against reinfection. To enforce tissue retention, Trm cells up-regulate CD69 and down-regulate molecules associated with tissue egress; however, a Trm-specific transcriptional regulator has not been identified. Here, we show that the transcription factor Hobit is specifically up-regulated in Trm cells and, together with related Blimp1, mediates the development of Trm cells in skin, gut, liver, and kidney in mice. The Hobit-Blimp1 transcriptional module is also required for other populations of tissue-resident lymphocytes, including natural killer T (NKT) cells and liver-resident NK cells, all of which share a common transcriptional program. Our results identify Hobit and Blimp1 as central regulators of this universal program that instructs tissue retention in diverse tissue-resident lymphocyte populations.

Copyright © 2016, American Association for the Advancement of Science.

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