Functional Gastrointestinal Disorders: History, Pathophysiology, Clinical Features and Rome IV - PubMed (original) (raw)
. 2016 Feb 19:S0016-5085(16)00223-7.
doi: 10.1053/j.gastro.2016.02.032. Online ahead of print.
- PMID: 27144617
- DOI: 10.1053/j.gastro.2016.02.032
Functional Gastrointestinal Disorders: History, Pathophysiology, Clinical Features and Rome IV
Douglas A Drossman. Gastroenterology. 2016.
Abstract
Functional gastrointestinal disorders (FGIDs), the most common diagnoses in gastroenterology are recognized by morphological and physiological abnormalities that often occur in combination including motility disturbance, visceral hypersensitivity, altered mucosal and immune function, altered gut microbiota and altered central nervous system processing. Research on these gut-brain interaction disorders is based on using specific diagnostic criteria. The Rome Foundation has played a pivotal role in creating diagnostic criteria thus operationalizing the dissemination of new knowledge in the field of FGIDs. Rome IV is a compendium of the knowledge accumulated since Rome III was published 10 years ago. It improves upon Rome III by: 1) updating the basic and clinical literature, 2) offering new information on gut microenvironment, gut-brain interactions, pharmacogenomics, biopsychosocial, gender and cross cultural understandings of FGIDs, 3) reduces the use of imprecise and occassionally stigmatizing terms when possible, 4) uses updated diagnostic algorithms, 5) incorporates information on the patient illness experience, and physiological subgroups or biomarkers that might lead to more targeted treatment. This introductory article sets the stage for the remaining 17 articles that follow and offers an historical overview of the FGIDs field, differentiates FGIDs from motility and structural disorders, discusses the changes from Rome III, reviews the Rome committee process, provides a biopsychosocial pathophysiological conceptualization of FGIDs, and offers an approach to patient care.
Keywords: Biopsychosocial Model; Classification; Diagnosis; Functional GI Disorders; History; Neurogastroenterology; Patient Provider Relationship; Rome Criteria; Rome Foundation; Rome IV; Treatment approach.
Copyright © 2016 AGA Institute. Published by Elsevier Inc. All rights reserved.
Similar articles
- What Is New in Rome IV.
Schmulson MJ, Drossman DA. Schmulson MJ, et al. J Neurogastroenterol Motil. 2017 Apr 30;23(2):151-163. doi: 10.5056/jnm16214. J Neurogastroenterol Motil. 2017. PMID: 28274109 Free PMC article. Review. - Diagnostic Accuracy of the Rome IV Criteria for the Diagnosis of Functional Gastrointestinal Disorders in Children.
Velasco-Benítez CA, Gómez-Oliveros LF, Rubio-Molina LM, Tovar-Cuevas JR, Saps M. Velasco-Benítez CA, et al. J Pediatr Gastroenterol Nutr. 2021 Apr 1;72(4):538-541. doi: 10.1097/MPG.0000000000003030. J Pediatr Gastroenterol Nutr. 2021. PMID: 33394887 - What's new in Rome IV?
Tack J, Drossman DA. Tack J, et al. Neurogastroenterol Motil. 2017 Sep;29(9). doi: 10.1111/nmo.13053. Epub 2017 Mar 17. Neurogastroenterol Motil. 2017. PMID: 28303651 Review. - Neuromodulators for Functional Gastrointestinal Disorders (Disorders of Gut-Brain Interaction): A Rome Foundation Working Team Report.
Drossman DA, Tack J, Ford AC, Szigethy E, Törnblom H, Van Oudenhove L. Drossman DA, et al. Gastroenterology. 2018 Mar;154(4):1140-1171.e1. doi: 10.1053/j.gastro.2017.11.279. Epub 2017 Dec 22. Gastroenterology. 2018. PMID: 29274869 Review. - Long-Term Study of Children With ROME III Functional Gastrointestinal Disorders Managed Symptomatically in a Biopsychosocial Model.
Madani S, Parikh S, Madani RS, Krasaelap A. Madani S, et al. Gastroenterology Res. 2017 Apr;10(2):84-91. doi: 10.14740/gr798w. Epub 2017 Apr 19. Gastroenterology Res. 2017. PMID: 28496528 Free PMC article.
Cited by
- Evaluating disorders of gut-brain interaction in eating disorders.
Wiklund CA, Rania M, Kuja-Halkola R, Thornton LM, Bulik CM. Wiklund CA, et al. Int J Eat Disord. 2021 Jun;54(6):925-935. doi: 10.1002/eat.23527. Epub 2021 May 6. Int J Eat Disord. 2021. PMID: 33955041 Free PMC article. - Modulating the gut microenvironment as a treatment strategy for irritable bowel syndrome: a narrative review.
Iribarren C, Maasfeh L, Öhman L, Simrén M. Iribarren C, et al. Gut Microbiome (Camb). 2022 Aug 25;3:e7. doi: 10.1017/gmb.2022.6. eCollection 2022. Gut Microbiome (Camb). 2022. PMID: 39295774 Free PMC article. Review. - Bugs and Brains, the Gut and Mental Health Study: a mixed-methods study investigating microbiota composition and function in anxiety, depression and irritable bowel syndrome.
Simpson CA, Schwartz OS, Eliby D, Butler CA, Huang K, O'Brien-Simpson N, Callaghan BL, Dashper SG, Gooley PR, Whittle S, Haslam N, Simmons JG. Simpson CA, et al. BMJ Open. 2021 Mar 15;11(3):e043221. doi: 10.1136/bmjopen-2020-043221. BMJ Open. 2021. PMID: 33722869 Free PMC article. - Association of Functional Gastrointestinal Disorders with Adolescent Idiopathic Scoliosis.
Lee SB, Chae HW, Kwon JW, Sung S, Moon SH, Suk KS, Kim HS, Park SY, Lee BH. Lee SB, et al. Children (Basel). 2024 Jan 18;11(1):118. doi: 10.3390/children11010118. Children (Basel). 2024. PMID: 38255431 Free PMC article. - Functional Gastrointestinal Disorders in Neonates and Toddlers According to the Rome IV Criteria: A Systematic Review and Meta-Analysis.
Velasco-Benítez CA, Collazos-Saa LI, García-Perdomo HA. Velasco-Benítez CA, et al. Pediatr Gastroenterol Hepatol Nutr. 2022 Sep;25(5):376-386. doi: 10.5223/pghn.2022.25.5.376. Epub 2022 Sep 5. Pediatr Gastroenterol Hepatol Nutr. 2022. PMID: 36148289 Free PMC article.
LinkOut - more resources
Full Text Sources
Other Literature Sources