Stimulatory role of transforming growth factors in multistage skin carcinogenesis: possible explanation for the tumor-inducing effect of wounding in initiated NMRI mouse skin - PubMed (original) (raw)
. 1989 May 15;43(5):915-21.
doi: 10.1002/ijc.2910430531.
Affiliations
- PMID: 2714898
- DOI: 10.1002/ijc.2910430531
Stimulatory role of transforming growth factors in multistage skin carcinogenesis: possible explanation for the tumor-inducing effect of wounding in initiated NMRI mouse skin
G Fürstenberger et al. Int J Cancer. 1989.
Abstract
Mechanical wounding provides a convertogenic ("stage I tumor-promoting") stimulus in initiated NMRI mouse skin, indicating that this stage of carcinogenesis can be entirely controlled by endogenous factors. A search for such factors led to the finding that both platelet-derived Epstein-Barr-virus-inducing factor (EIF), alias human TGF beta 1 and porcine TGF beta, exhibited--upon intracutaneous injection--convertogenic efficacy in initiated NMRI-mouse skin in vivo provided that their injection was combined with a single topical application of the non-convertogenic tumor promoter 12-O-retinolyphorbol-13-acetate (RPA). Since TGF beta inhibits epidermal cell proliferation, the RPA treatment is thought to provide a mitogenic stimulus required for conversion. The RPA treatment can be replaced by intracutaneous injection of transforming growth factor alpha (TGF alpha). These results indicate that the stage of conversion consists of two components, one of which is related to mitogenesis (RPA or TGF alpha), the other to a still unknown activity exhibited by TGF beta-like factors. Thus, endogenous factors with the quality of "wound hormones" may be involved in multistage skin carcinogenesis. This finding could explain the convertogenic effect of skin wounding.
Similar articles
- Effects of complete and incomplete tumor promoters on hair growth, angiogenesis, and tenascin expression in the skin of NMRI mice.
Ushmorov AG, Fürstenberger G, Faissner A, Marks F. Ushmorov AG, et al. Carcinogenesis. 1994 Dec;15(12):2739-45. doi: 10.1093/carcin/15.12.2739. Carcinogenesis. 1994. PMID: 7528111 - Multistage tumor promotion in skin.
Marks F, Fürstenberger G. Marks F, et al. Princess Takamatsu Symp. 1983;14:273-87. Princess Takamatsu Symp. 1983. PMID: 6440893 Review. - Role of the epidermal growth factor receptor and transforming growth factor alpha in mouse skin carcinogenesis.
DiGiovanni J, Rho O, Xian W, Beltràn L. DiGiovanni J, et al. Prog Clin Biol Res. 1994;387:113-38. Prog Clin Biol Res. 1994. PMID: 7972243 Review.
Cited by
- Loss of expression of transforming growth factor beta in skin and skin tumors is associated with hyperproliferation and a high risk for malignant conversion.
Glick AB, Kulkarni AB, Tennenbaum T, Hennings H, Flanders KC, O'Reilly M, Sporn MB, Karlsson S, Yuspa SH. Glick AB, et al. Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):6076-80. doi: 10.1073/pnas.90.13.6076. Proc Natl Acad Sci U S A. 1993. PMID: 7687059 Free PMC article. - The role of transforming growth factor beta in glioma progression.
Jennings MT, Pietenpol JA. Jennings MT, et al. J Neurooncol. 1998 Jan;36(2):123-40. doi: 10.1023/a:1005863419880. J Neurooncol. 1998. PMID: 9525812 Review. - Arsenic enhancement of skin neoplasia by chronic stimulation of growth factors.
Germolec DR, Spalding J, Yu HS, Chen GS, Simeonova PP, Humble MC, Bruccoleri A, Boorman GA, Foley JF, Yoshida T, Luster MI. Germolec DR, et al. Am J Pathol. 1998 Dec;153(6):1775-85. doi: 10.1016/S0002-9440(10)65692-1. Am J Pathol. 1998. PMID: 9846968 Free PMC article. - Advances in cutaneous squamous cell carcinoma.
Winge MCG, Kellman LN, Guo K, Tang JY, Swetter SM, Aasi SZ, Sarin KY, Chang ALS, Khavari PA. Winge MCG, et al. Nat Rev Cancer. 2023 Jul;23(7):430-449. doi: 10.1038/s41568-023-00583-5. Epub 2023 Jun 7. Nat Rev Cancer. 2023. PMID: 37286893 Review. - Plasticity of differentiated cells in wound repair and tumorigenesis, part II: skin and intestine.
Burclaff J, Mills JC. Burclaff J, et al. Dis Model Mech. 2018 Aug 31;11(9):dmm035071. doi: 10.1242/dmm.035071. Dis Model Mech. 2018. PMID: 30171151 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical