Loss of Chromosome 8p Governs Tumor Progression and Drug Response by Altering Lipid Metabolism - PubMed (original) (raw)
. 2016 May 9;29(5):751-766.
doi: 10.1016/j.ccell.2016.04.003.
Jonathan Crowther 1, Tibor Pastor 1, Layka Abbasi Asbagh 2, Maria Francesca Baietti 1, Magdalena De Troyer 1, Iria Vazquez 1, Ali Talebi 2, Fabrizio Renzi 1, Jonas Dehairs 2, Johannes V Swinnen 2, Anna A Sablina 3
Affiliations
- PMID: 27165746
- DOI: 10.1016/j.ccell.2016.04.003
Free article
Loss of Chromosome 8p Governs Tumor Progression and Drug Response by Altering Lipid Metabolism
Yanyan Cai et al. Cancer Cell. 2016.
Free article
Abstract
Large-scale heterozygous deletions are a hallmark of cancer genomes. The concomitant loss of multiple genes creates vulnerabilities that are impossible to reveal through the study of individual genes. To delineate the functional outcome of chromosome 8p loss of heterozygosity (LOH), a common aberration in breast cancer, we modeled 8p LOH using TALEN-based genomic engineering. 8p LOH alters fatty acid and ceramide metabolism. The shift in lipid metabolism triggers invasiveness and confers tumor growth under stress conditions due to increased autophagy. The resistance of 8p-deleted cells to chemotherapeutic drugs concurs with poorer survival rates of breast cancer patients harboring an 8p LOH. The autophagy dependency of 8p-deleted cells provides the rational basis for treatment of 8p LOH tumors with autophagy inhibitors.
Copyright © 2016 Elsevier Inc. All rights reserved.
Comment in
- Coordinated Tumor Suppression by Chromosome 8p.
Tschaharganeh DF, Bosbach B, Lowe SW. Tschaharganeh DF, et al. Cancer Cell. 2016 May 9;29(5):617-619. doi: 10.1016/j.ccell.2016.04.011. Cancer Cell. 2016. PMID: 27165739 Free PMC article.
Similar articles
- 8p deletion is strongly linked to poor prognosis in breast cancer.
Lebok P, Mittenzwei A, Kluth M, Özden C, Taskin B, Hussein K, Möller K, Hartmann A, Lebeau A, Witzel I, Mahner S, Wölber L, Jänicke F, Geist S, Paluchowski P, Wilke C, Heilenkötter U, Simon R, Sauter G, Terracciano L, Krech R, von der Assen A, Müller V, Burandt E. Lebok P, et al. Cancer Biol Ther. 2015;16(7):1080-7. doi: 10.1080/15384047.2015.1046025. Epub 2015 May 11. Cancer Biol Ther. 2015. PMID: 25961141 Free PMC article. - Allelic loss of chromosomal arm 8p in breast cancer progression.
Anbazhagan R, Fujii H, Gabrielson E. Anbazhagan R, et al. Am J Pathol. 1998 Mar;152(3):815-9. Am J Pathol. 1998. PMID: 9502423 Free PMC article. - Loss of heterozygosity from the short arm of chromosome 8 is associated with invasive behavior in breast cancer.
Yaremko ML, Kutza C, Lyzak J, Mick R, Recant WM, Westbrook CA. Yaremko ML, et al. Genes Chromosomes Cancer. 1996 Jul;16(3):189-95. doi: 10.1002/(SICI)1098-2264(199607)16:3<189::AID-GCC6>3.0.CO;2-V. Genes Chromosomes Cancer. 1996. PMID: 8814452 - Complex CGH alterations on chromosome arm 8p at candidate tumor suppressor gene loci in breast cancer cell lines.
Venter DJ, Ramus SJ, Hammet FM, de Silva M, Hutchins AM, Petrovic V, Price G, Armes JE. Venter DJ, et al. Cancer Genet Cytogenet. 2005 Jul 15;160(2):134-40. doi: 10.1016/j.cancergencyto.2004.12.007. Cancer Genet Cytogenet. 2005. PMID: 15993269 - Deletions of chromosome 8p and loss of sFRP1 expression are progression markers of papillary bladder cancer.
Stoehr R, Wissmann C, Suzuki H, Knuechel R, Krieg RC, Klopocki E, Dahl E, Wild P, Blaszyk H, Sauter G, Simon R, Schmitt R, Zaak D, Hofstaedter F, Rosenthal A, Baylin SB, Pilarsky C, Hartmann A. Stoehr R, et al. Lab Invest. 2004 Apr;84(4):465-78. doi: 10.1038/labinvest.3700068. Lab Invest. 2004. PMID: 14968126
Cited by
- Targeting Lipid Metabolism in Cancer Stem Cells for Anticancer Treatment.
Singh MK, Han S, Kim S, Kang I. Singh MK, et al. Int J Mol Sci. 2024 Oct 17;25(20):11185. doi: 10.3390/ijms252011185. Int J Mol Sci. 2024. PMID: 39456967 Free PMC article. Review. - The value of chromosome instability detected by low-pass whole-genome sequencing in preoperative prediction of sentinel lymph node metastasis in breast cancer.
Zheng J, Xu F, Li G, Lin M, Hao H. Zheng J, et al. Front Oncol. 2024 Oct 4;14:1434526. doi: 10.3389/fonc.2024.1434526. eCollection 2024. Front Oncol. 2024. PMID: 39429474 Free PMC article. - Aneuploidy as a driver of human cancer.
Sdeor E, Okada H, Saad R, Ben-Yishay T, Ben-David U. Sdeor E, et al. Nat Genet. 2024 Oct;56(10):2014-2026. doi: 10.1038/s41588-024-01916-2. Epub 2024 Oct 2. Nat Genet. 2024. PMID: 39358600 Review. - Upregulation of Apoptosis Related Genes in Clinically Normal Tongue Contralateral to Squamous Cell Carcinoma of the Oral Tongue, an Effort to Maintain Tissue Homeostasis.
Attaran N, Coates PJ, Zborayova K, Sgaramella N, Nylander K, Gu X. Attaran N, et al. Head Neck Pathol. 2024 Sep 30;18(1):89. doi: 10.1007/s12105-024-01695-6. Head Neck Pathol. 2024. PMID: 39348078 Free PMC article. - Advances in delivery systems for CRISPR/Cas-mediated cancer treatment: a focus on viral vectors and extracellular vesicles.
Song Z, Tao Y, Liu Y, Li J. Song Z, et al. Front Immunol. 2024 Aug 30;15:1444437. doi: 10.3389/fimmu.2024.1444437. eCollection 2024. Front Immunol. 2024. PMID: 39281673 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical