Relationship of serum uric acid level with non-alcoholic fatty liver disease and its inflammation progression in non-obese adults - PubMed (original) (raw)

. 2017 Mar;47(3):E104-E112.

doi: 10.1111/hepr.12734. Epub 2016 Jun 29.

Chengfu Xu 2, Limei Ying 3, Shufei Zang 4, Zhenjie Zhuang 5, Haifeng Lv 6, Wenjun Yang 7, Yan Luo 5, Xaojie Ma 1, Lei Wang 8, Yunhao Xun 9, Dewei Ye 10, Junping Shi 1

Affiliations

Relationship of serum uric acid level with non-alcoholic fatty liver disease and its inflammation progression in non-obese adults

Jing Liu et al. Hepatol Res. 2017 Mar.

Abstract

Aim: This study aimed to evaluate the relationship between serum uric acid (SUA) level and non-alcoholic fatty liver disease (NAFLD) in non-obese adults.

Methods: A cross-sectional study was carried out among 4098 adults, including 1936 non-obese and 2162 obese individuals. An additional 93 non-obese adults with biopsy-proven NAFLD were also included.

Results: The overall prevalence of NAFLD was 39.51% in the study group, and 14.88% in non-obese adults. The NAFLD patients had significantly higher SUA levels than controls in both men and women. The non-obese group had a higher NAFLD risk with increased SUA levels than the obese group, with odd ratios (95% confidence interval) of 2.559 (1.870-3.503) and 1.692 (1.371-2.087), respectively. In 93 non-obese adults with biopsy-proven NAFLD, SUA levels were significantly higher in those with non-alcoholic steatohepatitis. The prevalence of non-alcoholic steatohepatitis and lobule inflammation tended to increase to 57.58% and 66.67% as the SUA level increased to the fourth quartile. Subjects with hyperuricemia had significantly higher NAFLD activity scores and more serious lobule inflammation than the normal group.

Conclusion: Non-obese adults have higher NAFLD risk with increased SUA levels than obese individuals, and the inflammation progression of NAFLD is associated with increased SUA level in non-obese subjects.

Keywords: inflammation progression; non-alcoholic fatty liver disease; non-obese adults; uric acid.

© 2016 The Japan Society of Hepatology.

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