Voltage-Gated Ion Channels in the PNS: Novel Therapies for Neuropathic Pain? - PubMed (original) (raw)
Review
. 2016 Jul;37(7):522-542.
doi: 10.1016/j.tips.2016.05.002. Epub 2016 May 24.
Affiliations
- PMID: 27233519
- DOI: 10.1016/j.tips.2016.05.002
Review
Voltage-Gated Ion Channels in the PNS: Novel Therapies for Neuropathic Pain?
Gareth R Tibbs et al. Trends Pharmacol Sci. 2016 Jul.
Abstract
Neuropathic pain arises from injury to the nervous system. Conditions associated with neuropathic pain are diverse, and lesions and/or pathological changes in the central nervous system (CNS) or peripheral nervous system (PNS) can frequently, but not always, be identified. It is difficult to treat, with patients often on multiple, different classes of medications, all with appreciable adverse side effect profiles. Consequently, there is a pressing need for the development of new medications. The development of such therapeutics is predicated on a clear understanding of the relevant molecular and cellular processes that contribute to the development, and maintenance, of the neuropathic pain state. One proposed mechanism thought to contribute to the ontogeny of neuropathic pain is altered expression, trafficking, and functioning of ion channels expressed by primary sensory neurons. Here, we will focus on three voltage-gated ion channel families, CaV, HCN, and NaV, first reviewing the preclinical data and then the human data where it exists.
Keywords: Ca(V) channel; HCN channel; Na(V) channel; chemotherapy; diabetes; nerve injury.
Copyright © 2016 Elsevier Ltd. All rights reserved.
Similar articles
- Voltage-gated Na+ channels in neuropathic pain.
Hargus NJ, Patel MK. Hargus NJ, et al. Expert Opin Investig Drugs. 2007 May;16(5):635-46. doi: 10.1517/13543784.16.5.635. Expert Opin Investig Drugs. 2007. PMID: 17461737 Review. - Inflammatory and neuropathic pain are rapidly suppressed by peripheral block of hyperpolarisation-activated cyclic nucleotide-gated ion channels.
Young GT, Emery EC, Mooney ER, Tsantoulas C, McNaughton PA. Young GT, et al. Pain. 2014 Sep;155(9):1708-1719. doi: 10.1016/j.pain.2014.05.021. Epub 2014 May 23. Pain. 2014. PMID: 24861581 - A peripherally acting, selective T-type calcium channel blocker, ABT-639, effectively reduces nociceptive and neuropathic pain in rats.
Jarvis MF, Scott VE, McGaraughty S, Chu KL, Xu J, Niforatos W, Milicic I, Joshi S, Zhang Q, Xia Z. Jarvis MF, et al. Biochem Pharmacol. 2014 Jun 15;89(4):536-44. doi: 10.1016/j.bcp.2014.03.015. Epub 2014 Apr 12. Biochem Pharmacol. 2014. PMID: 24726441 - Translational Model Systems for Complex Sodium Channel Pathophysiology in Pain.
Schrenk-Siemens K, Rösseler C, Lampert A. Schrenk-Siemens K, et al. Handb Exp Pharmacol. 2018;246:355-369. doi: 10.1007/164_2017_91. Handb Exp Pharmacol. 2018. PMID: 29374838 Review. - HCN2 ion channels play a central role in inflammatory and neuropathic pain.
Emery EC, Young GT, Berrocoso EM, Chen L, McNaughton PA. Emery EC, et al. Science. 2011 Sep 9;333(6048):1462-6. doi: 10.1126/science.1206243. Science. 2011. PMID: 21903816
Cited by
- HCN Channels: New Therapeutic Targets for Pain Treatment.
Ramírez D, Zúñiga R, Concha G, Zúñiga L. Ramírez D, et al. Molecules. 2018 Aug 21;23(9):2094. doi: 10.3390/molecules23092094. Molecules. 2018. PMID: 30134541 Free PMC article. Review. - Analgesic effects of Phα1β toxin: a review of mechanisms of action involving pain pathways.
da Silva JF, Binda NS, Pereira EMR, de Lavor MSL, Vieira LB, de Souza AH, Rigo FK, Ferrer HT, de Castro CJ, Ferreira J, Gomez MV. da Silva JF, et al. J Venom Anim Toxins Incl Trop Dis. 2021 Nov 22;27:e20210001. doi: 10.1590/1678-9199-JVATITD-2021-0001. eCollection 2021. J Venom Anim Toxins Incl Trop Dis. 2021. PMID: 34868281 Free PMC article. Review. - Emerging Medications and Strategies in Acute Pain Management: Evolving Role of Novel Sodium and Calcium Channel Blockers, Peptide-Based Pharmacologic Drugs, and Non-Medicinal Methods.
Kaye AD, Greene DR, Nguyen C, Ragland A, Granger MP, Wilhite WP, Dufrene K, Shekoohi S, Robinson CL. Kaye AD, et al. Curr Pain Headache Rep. 2024 Sep;28(9):853-862. doi: 10.1007/s11916-024-01265-z. Epub 2024 May 18. Curr Pain Headache Rep. 2024. PMID: 38761297 Review. - Spatial transcriptomics and single-nucleus RNA sequencing reveal a transcriptomic atlas of adult human spinal cord.
Zhang D, Chen Y, Wei Y, Chen H, Wu Y, Wu L, Li J, Ren Q, Miao C, Zhu T, Liu J, Ke B, Zhou C. Zhang D, et al. Elife. 2024 Jan 30;12:RP92046. doi: 10.7554/eLife.92046. Elife. 2024. PMID: 38289829 Free PMC article. - Partners in Crime: Towards New Ways of Targeting Calcium Channels.
Noyer L, Lemonnier L, Mariot P, Gkika D. Noyer L, et al. Int J Mol Sci. 2019 Dec 16;20(24):6344. doi: 10.3390/ijms20246344. Int J Mol Sci. 2019. PMID: 31888223 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources