Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes - PubMed (original) (raw)
Randomized Controlled Trial
. 2016 Jul 28;375(4):323-34.
doi: 10.1056/NEJMoa1515920. Epub 2016 Jun 14.
Affiliations
- PMID: 27299675
- DOI: 10.1056/NEJMoa1515920
Free article
Randomized Controlled Trial
Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes
Christoph Wanner et al. N Engl J Med. 2016.
Free article
Abstract
Background: Diabetes confers an increased risk of adverse cardiovascular and renal events. In the EMPA-REG OUTCOME trial, empagliflozin, a sodium-glucose cotransporter 2 inhibitor, reduced the risk of major adverse cardiovascular events in patients with type 2 diabetes at high risk for cardiovascular events. We wanted to determine the long-term renal effects of empagliflozin, an analysis that was a prespecified component of the secondary microvascular outcome of that trial.
Methods: We randomly assigned patients with type 2 diabetes and an estimated glomerular filtration rate of at least 30 ml per minute per 1.73 m(2) of body-surface area to receive either empagliflozin (at a dose of 10 mg or 25 mg) or placebo once daily. Prespecified renal outcomes included incident or worsening nephropathy (progression to macroalbuminuria, doubling of the serum creatinine level, initiation of renal-replacement therapy, or death from renal disease) and incident albuminuria.
Results: Incident or worsening nephropathy occurred in 525 of 4124 patients (12.7%) in the empagliflozin group and in 388 of 2061 (18.8%) in the placebo group (hazard ratio in the empagliflozin group, 0.61; 95% confidence interval, 0.53 to 0.70; P<0.001). Doubling of the serum creatinine level occurred in 70 of 4645 patients (1.5%) in the empagliflozin group and in 60 of 2323 (2.6%) in the placebo group, a significant relative risk reduction of 44%. Renal-replacement therapy was initiated in 13 of 4687 patients (0.3%) in the empagliflozin group and in 14 of 2333 patients (0.6%) in the placebo group, representing a 55% lower relative risk in the empagliflozin group. There was no significant between-group difference in the rate of incident albuminuria. The adverse-event profile of empagliflozin in patients with impaired kidney function at baseline was similar to that reported in the overall trial population.
Conclusions: In patients with type 2 diabetes at high cardiovascular risk, empagliflozin was associated with slower progression of kidney disease and lower rates of clinically relevant renal events than was placebo when added to standard care. (Funded by the Boehringer Ingelheim and Eli Lilly and Company Diabetes Alliance; EMPA-REG OUTCOME ClinicalTrials.gov number, NCT01131676.).
Comment in
- Cardiac and Renovascular Complications in Type 2 Diabetes--Is There Hope?
Ingelfinger JR, Rosen CJ. Ingelfinger JR, et al. N Engl J Med. 2016 Jul 28;375(4):380-2. doi: 10.1056/NEJMe1607413. Epub 2016 Jun 14. N Engl J Med. 2016. PMID: 27331286 No abstract available. - Diabetic nephropathy: SGLT2 inhibitors might halt progression of diabetic nephropathy.
Yamout H, Bakris GL. Yamout H, et al. Nat Rev Nephrol. 2016 Oct;12(10):583-4. doi: 10.1038/nrneph.2016.109. Epub 2016 Jul 18. Nat Rev Nephrol. 2016. PMID: 27425155 No abstract available. - In patients with type 2 diabetes and CVD, empagliflozin reduced incident or worsening nephropathy at 3.1 y.
Patel T. Patel T. Ann Intern Med. 2016 Oct 18;165(8):JC39. doi: 10.7326/ACPJC-2016-165-8-039. Ann Intern Med. 2016. PMID: 27750299 No abstract available. - Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes.
Wanner Ch, Inzucchi SE, Zinman B. Wanner Ch, et al. N Engl J Med. 2016 Nov 3;375(18):1801-2. doi: 10.1056/NEJMc1611290. N Engl J Med. 2016. PMID: 27806236 No abstract available. - Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes.
Wakisaka M. Wakisaka M. N Engl J Med. 2016 Nov 3;375(18):1799-1800. doi: 10.1056/NEJMc1611290. N Engl J Med. 2016. PMID: 27806237 No abstract available. - Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes.
Pareek A, Chandurkar N, Naidu K. Pareek A, et al. N Engl J Med. 2016 Nov 3;375(18):1800. doi: 10.1056/NEJMc1611290. N Engl J Med. 2016. PMID: 27806238 No abstract available. - Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes.
Parving H-H, Lambers-Heerspink H, de Zeeuw D. Parving H-H, et al. N Engl J Med. 2016 Nov 3;375(18):1800-1. doi: 10.1056/NEJMc1611290. N Engl J Med. 2016. PMID: 28106974 No abstract available.
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