Influence of site on the chemosensitivity of transplantable murine colon tumours to flavone acetic acid (LM975, NSC 347512) - PubMed (original) (raw)
Influence of site on the chemosensitivity of transplantable murine colon tumours to flavone acetic acid (LM975, NSC 347512)
M C Bibby et al. Cancer Chemother Pharmacol. 1989.
Abstract
A number of experimental studies have demonstrated significant responses of s.c. solid tumours to flavone acetic acid (FAA). Clinical studies to date have been disappointing, with no objective responses being seen. The present study demonstrated that the tumour site is important for the anti-tumour action of FAA against two transplantable adenocarcinoma lines (MAC) in NMRI mice. Responses were achievable only when the tumours were implanted s.c. Ascitic or systemic tumours did not respond to FAA. Experimentally achievable plasma levels of FAA were not sufficient to induce significant cell kills in either MAC 15A or MAC 26 cell lines in vitro. A poor correlation exists between in vitro and in vivo responses, as the clonogenic assay could not predict the response of the solid MAC tumours grown s.c. The in vitro data indicated that the length of exposure to FAA was important, with long exposure times being necessary for cytotoxicity to develop, in these tumour cell lines. These studies imply that more than one mechanism is involved, and it is likely that the activity of FAA against s.c. tumours relies at least in part on a specific biological feature of tumours in this site. However, it may still be possible to achieve systemic tumour cell kill in vivo by increasing drug-exposure times.
Similar articles
- Unique chemosensitivity of MAC 16 tumours to flavone acetic acid (LM975, NSC 347512).
Bibby MC, Double JA, Loadman PM. Bibby MC, et al. Br J Cancer. 1988 Sep;58(3):341-4. doi: 10.1038/bjc.1988.215. Br J Cancer. 1988. PMID: 3179187 Free PMC article. - Factors involved in the anti-cancer activity of the investigational agents LM985 (flavone acetic acid ester) and LM975 (flavone acetic acid).
Bibby MC, Double JA, Phillips RM, Loadman PM. Bibby MC, et al. Br J Cancer. 1987 Feb;55(2):159-63. doi: 10.1038/bjc.1987.32. Br J Cancer. 1987. PMID: 3814485 Free PMC article. - The relationship between tissue levels of flavone acetic acid (NSC 347512) and site dependent anti-tumour activity in murine colon tumours.
Bibby MC, Phillips RM, Double JA. Bibby MC, et al. Br J Cancer. 1991 Apr;63(4):541-5. doi: 10.1038/bjc.1991.127. Br J Cancer. 1991. PMID: 2021538 Free PMC article. - Flavone 8-acetic acid: our current understanding of its mechanism of action in solid tumours.
Cummings J, Smyth JF. Cummings J, et al. Cancer Chemother Pharmacol. 1989;24(5):269-72. doi: 10.1007/BF00304756. Cancer Chemother Pharmacol. 1989. PMID: 2667786 Review. - Flavone acetic acid (LM 975, NSC 347512). A novel antitumor agent.
O'Dwyer PJ, Shoemaker D, Zaharko DS, Grieshaber C, Plowman J, Corbett T, Valeriote F, King SA, Cradock J, Hoth DF, et al. O'Dwyer PJ, et al. Cancer Chemother Pharmacol. 1987;19(1):6-10. doi: 10.1007/BF00296246. Cancer Chemother Pharmacol. 1987. PMID: 3545524 Review.
Cited by
- In vivo and in vitro evaluation of combretastatin A-4 and its sodium phosphate prodrug.
Grosios K, Holwell SE, McGown AT, Pettit GR, Bibby MC. Grosios K, et al. Br J Cancer. 1999 Dec;81(8):1318-27. doi: 10.1038/sj.bjc.6692174. Br J Cancer. 1999. PMID: 10604728 Free PMC article. - Preclinical in vitro and in vivo activity of 5,6-dimethylxanthenone-4-acetic acid.
Laws AL, Matthew AM, Double JA, Bibby MC. Laws AL, et al. Br J Cancer. 1995 Jun;71(6):1204-9. doi: 10.1038/bjc.1995.234. Br J Cancer. 1995. PMID: 7779712 Free PMC article. - The use of vascularised spheroids to investigate the action of flavone acetic acid on tumour blood vessels.
Zwi LJ, Baguley BC, Gavin JB, Wilson WR. Zwi LJ, et al. Br J Cancer. 1990 Aug;62(2):231-7. doi: 10.1038/bjc.1990.266. Br J Cancer. 1990. PMID: 2386739 Free PMC article. - Flavone acetic acid antitumour activity against a mouse pancreatic adenocarcinoma is mediated by natural killer cells.
Damia G, Tagliabue G, Allavena P, D'Incalci M. Damia G, et al. Cancer Immunol Immunother. 1990;32(4):241-4. doi: 10.1007/BF01741707. Cancer Immunol Immunother. 1990. PMID: 2261598 Free PMC article.
References
- Br J Cancer. 1987 Mar;55(3):233-8 - PubMed
- Eur J Cancer Clin Oncol. 1987 Aug;23(8):1209-11 - PubMed
- Eur J Cancer Clin Oncol. 1987 Aug;23(8):1135-9 - PubMed
- Prog Clin Biol Res. 1988;280:243-6 - PubMed
- Invest New Drugs. 1986;4(3):207-20 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Miscellaneous