Meta-analysis of the efficacy of proton pump inhibitors for the symptoms of laryngopharyngeal reflux - PubMed (original) (raw)

Meta-Analysis

Meta-analysis of the efficacy of proton pump inhibitors for the symptoms of laryngopharyngeal reflux

C Liu et al. Braz J Med Biol Res. 2016.

Abstract

The objective of this study was to perform a systematic review and meta-analysis to assess the effectiveness of proton pump inhibitors (PPI) for reflux disease in adult patients with laryngopharyngeal symptoms. A comprehensive search of Cochrane Library, EMBASE, Ovid EBM Reviews, and PubMed was performed for English-language literature about laryngopharyngeal reflux (LPR), in September 2014. The papers were filtered using pre-defined inclusion and exclusion criteria. Eight papers were identified and included in this meta-analysis. The sample comprised a pooled total of 370 patients, of which 210 and 160 patients took PPIs and placebo, respectively. The difference between PPIs and placebo groups in overall improvement of symptoms in adult patients with LPR was not statistically significant (RR=1.22; 95%CI=0.93-1.58; P=0.149). The difference in cough improvement was also not significant between PPIs and placebo groups (RR=0.65; 95%CI=0.30-1.41; P=0.279).

PubMed Disclaimer

Figures

Similar articles

• Proton pump inhibitors for the prevention of non-steroidal anti-inflammatory drug-induced ulcers and dyspepsia.
  Garegnani L, Oltra G, Burgos MA, Ivaldi D, Varela LB, Díaz Menai S, Puga-Tejada M, Escobar Liquitay CM, Franco JV. Garegnani L, et al. Cochrane Database Syst Rev. 2025 May 8;5(5):CD014585. doi: 10.1002/14651858.CD014585.pub2. Cochrane Database Syst Rev. 2025. PMID: 40337979
• Proton pump inhibitors for functional dyspepsia.
  Pinto-Sanchez MI, Yuan Y, Hassan A, Bercik P, Moayyedi P. Pinto-Sanchez MI, et al. Cochrane Database Syst Rev. 2017 Nov 21;11(11):CD011194. doi: 10.1002/14651858.CD011194.pub3. Cochrane Database Syst Rev. 2017. PMID: 29161458 Free PMC article.
• Proton pump inhibitors for functional dyspepsia.
  Pinto-Sanchez MI, Yuan Y, Bercik P, Moayyedi P. Pinto-Sanchez MI, et al. Cochrane Database Syst Rev. 2017 Mar 8;3(3):CD011194. doi: 10.1002/14651858.CD011194.pub2. Cochrane Database Syst Rev. 2017. PMID: 28271513 Free PMC article. Updated.
• The Role of Helicobacter pylori in Laryngopharyngeal Reflux.
  Campbell R, Kilty SJ, Hutton B, Bonaparte JP. Campbell R, et al. Otolaryngol Head Neck Surg. 2017 Feb;156(2):255-262. doi: 10.1177/0194599816676052. Epub 2016 Nov 1. Otolaryngol Head Neck Surg. 2017. PMID: 27803078
• The role of an anti-reflux diet in the treatment of chronic cough caused by laryngopharyngeal reflux.
  Hránková V, Balner T, Kondé A, Gubová P, Zeleník K, Komínek P, Staníková L. Hránková V, et al. Eur Arch Otorhinolaryngol. 2025 Apr;282(4):2009-2013. doi: 10.1007/s00405-025-09258-3. Epub 2025 Feb 24. Eur Arch Otorhinolaryngol. 2025. PMID: 39994032 Free PMC article.

Cited by

• Is Adjunctive Alginate Therapy Beneficial in the Treatment of Laryngopharyngeal Reflux Disease in a Rural Indian Population? A Prospective Randomized Study.
  Mathew AS, Shilpa H. Mathew AS, et al. Indian J Otolaryngol Head Neck Surg. 2022 Oct;74(Suppl 2):2104-2110. doi: 10.1007/s12070-020-02005-6. Epub 2020 Aug 6. Indian J Otolaryngol Head Neck Surg. 2022. PMID: 36452699 Free PMC article.
• Effects of acids, pepsin, bile acids, and trypsin on laryngopharyngeal reflux diseases: physiopathology and therapeutic targets.
  Li Y, Xu G, Zhou B, Tang Y, Liu X, Wu Y, Wang Y, Kong J, Xu T, He C, Zhu S, Wang X, Zhang J. Li Y, et al. Eur Arch Otorhinolaryngol. 2022 Jun;279(6):2743-2752. doi: 10.1007/s00405-021-07201-w. Epub 2021 Dec 3. Eur Arch Otorhinolaryngol. 2022. PMID: 34860271 Free PMC article. Review.
• Meta-analysis of Proton Pump Inhibitors in the Treatment of Pharyngeal Reflux Disease.
  Jin X, Zhou X, Fan Z, Qin Y, Zhan J. Jin X, et al. Comput Math Methods Med. 2022 Jul 21;2022:9105814. doi: 10.1155/2022/9105814. eCollection 2022. Comput Math Methods Med. 2022. PMID: 35912160 Free PMC article.
• ACG Clinical Guidelines: Clinical Use of Esophageal Physiologic Testing.
  Gyawali CP, Carlson DA, Chen JW, Patel A, Wong RJ, Yadlapati RH. Gyawali CP, et al. Am J Gastroenterol. 2020 Sep;115(9):1412-1428. doi: 10.14309/ajg.0000000000000734. Am J Gastroenterol. 2020. PMID: 32769426 Free PMC article.
• Establishment of a novel and effective reflux laryngitis model in rabbits: a preliminary study.
  Lou Z, Xue C, Kang J, Gong T, Scholp A, Jiang JJ. Lou Z, et al. Eur Arch Otorhinolaryngol. 2019 Jan;276(1):175-183. doi: 10.1007/s00405-018-5234-7. Epub 2018 Dec 10. Eur Arch Otorhinolaryngol. 2019. PMID: 30535974

References

1. 1. Koufman JA. The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury. Laryngoscope. 1991;101:1–78. doi: 10.1002/lary.5541011220. - DOI - PubMed
2. 1. Wong RK, Hanson DG, Waring PJ, Shaw G. ENT manifestations of gastroesophageal reflux. Am J Gastroenterol. 2000;95:S15–S22. doi: 10.1016/S0002-9270(00)01074-1. - DOI - PubMed
3. 1. Vardar R, Varis A, Bayrakci B, Akyildiz S, Kirazli T, Bor S. Relationship between history, laryngoscopy and esophagogastroduodenoscopy for diagnosis of laryngopharyngeal reflux in patients with typical GERD. Eur Arch Otorhinolaryngol. 2012;269:187–191. doi: 10.1007/s00405-011-1748-y. - DOI - PubMed
4. 1. Sen P, Georgalas C, Bhattacharyya AK. A systematic review of the role of proton pump inhibitors for symptoms of laryngopharyngeal reflux. Clin Otolaryngol. 2006;31:20–24. doi: 10.1111/j.1749-4486.2006.01134.x. - DOI - PubMed
5. 1. Shaheen NJ, Crockett SD, Bright SD, Madanick RD, Buckmire R, Couch M, et al. Randomised clinical trial: high-dose acid suppression for chronic cough - a double-blind, placebo-controlled study. Aliment Pharmacol Ther. 2011;33:225–234. doi: 10.1111/j.1365-2036.2010.04511.x. - DOI - PMC - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Europe PubMed Central
  • PubMed Central
  • Scientific Electronic Library Online

• Other Literature Sources

  • scite Smart Citations