Microbiota-Produced Succinate Improves Glucose Homeostasis via Intestinal Gluconeogenesis - PubMed (original) (raw)
. 2016 Jul 12;24(1):151-7.
doi: 10.1016/j.cmet.2016.06.013.
Affiliations
- PMID: 27411015
- DOI: 10.1016/j.cmet.2016.06.013
Free article
Microbiota-Produced Succinate Improves Glucose Homeostasis via Intestinal Gluconeogenesis
Filipe De Vadder et al. Cell Metab. 2016.
Free article
Abstract
Beneficial effects of dietary fiber on glucose and energy homeostasis have long been described, focusing mostly on the production of short-chain fatty acids by the gut commensal bacteria. However, bacterial fermentation of dietary fiber also produces large amounts of succinate and, to date, no study has focused on the role of succinate on host metabolism. Here, we fed mice a fiber-rich diet and found that succinate was the most abundant carboxylic acid in the cecum. Dietary succinate was identified as a substrate for intestinal gluconeogenesis (IGN), a process that improves glucose homeostasis. Accordingly, dietary succinate improved glucose and insulin tolerance in wild-type mice, but those effects were absent in mice deficient in IGN. Conventional mice colonized with the succinate producer Prevotella copri exhibited metabolic benefits, which could be related to succinate-activated IGN. Thus, microbiota-produced succinate is a previously unsuspected bacterial metabolite improving glycemic control through activation of IGN.
Copyright © 2016 Elsevier Inc. All rights reserved.
Comment in
- Strain-Level Diversity in the Gut: The P. copri Case.
Metwaly A, Haller D. Metwaly A, et al. Cell Host Microbe. 2019 Mar 13;25(3):349-350. doi: 10.1016/j.chom.2019.02.006. Cell Host Microbe. 2019. PMID: 30870618
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