Psychological morbidity associated with hyperemesis gravidarum: a systematic review and meta-analysis - PubMed (original) (raw)
Review
Psychological morbidity associated with hyperemesis gravidarum: a systematic review and meta-analysis
N Mitchell-Jones et al. BJOG. 2017 Jan.
Abstract
Background: Psychological illness occurring in association with hyperemesis gravidarum (HG) has been widely reported.
Objective: To determine if there is a higher incidence of psychological morbidity in women with HG compared with women without significant nausea and vomiting in pregnancy.
Search strategy: PubMed, MEDLINE, Embase and PsychINFO were searched up to September 2015.
Selection criteria: Articles referring to psychological morbidity in relation to HG. For meta-analysis case-control studies using numerical scales to compare psychological symptoms.
Data collection and analysis: Articles were independently assessed for inclusion by two reviewers and methodology was appraised using the Newcastle Ottawa Scale. Comparison was made using the standard mean difference (SMD) in symptom scale scores.
Main results: In all, 59 articles were included in the systematic review, 12 of these were used in the meta-analysis. Meta-analysis of depression scale scores demonstrated a very large effect with statistically significantly higher depression scale scores in women with HG (SMD 1.22; 95% CI 0.80-1.64; P ≤ 0.01) compared with controls. Meta-analysis of anxiety scores demonstrated a large effect with statistically significantly higher anxiety disorder scale scores in women with HG (SMD 0.86; 95% CI 0.53-1.19; P ≤ 0.01). In both analyses significant heterogeneity was identified (depression and HG I2 = 94%, P ≤ 0.01; anxiety and HG I2 = 84%, P = 0.02).
Conclusions: Our systematic review and meta-analysis have shown a significantly increased frequency of depression and anxiety in women with HG. The findings should prompt service development for women with HG that includes provision of psychological care and support.
Tweetable abstract: Meta-analysis demonstrates an increase in #PsychologicalMorbidity in women with #HyperemesisGravidarum.
Keywords: Anxiety; depression; hyperemesis gravidarum; pregnancy; sickness; vomiting.
© 2016 Royal College of Obstetricians and Gynaecologists.
Comment in
- Measures of depression and anxiety in women with hyperemesis gravidarum are flawed.
Fejzo MS. Fejzo MS. Evid Based Nurs. 2017 Jul;20(3):78-79. doi: 10.1136/eb-2017-102686. Epub 2017 Jun 10. Evid Based Nurs. 2017. PMID: 28601805 No abstract available.
Similar articles
- Perinatal outcomes of infants born to mothers with hyperemesis gravidarum: A systematic review and meta-analysis.
Jansen LAW, Nijsten K, Limpens J, van Eekelen R, Koot MH, Grooten IJ, Roseboom TJ, Painter RC. Jansen LAW, et al. Eur J Obstet Gynecol Reprod Biol. 2023 May;284:30-51. doi: 10.1016/j.ejogrb.2023.03.004. Epub 2023 Mar 11. Eur J Obstet Gynecol Reprod Biol. 2023. PMID: 36924660 Review. - Depression, anxiety, stress and hyperemesis gravidarum: temporal and case controlled correlates.
Tan PC, Zaidi SN, Azmi N, Omar SZ, Khong SY. Tan PC, et al. PLoS One. 2014 Mar 17;9(3):e92036. doi: 10.1371/journal.pone.0092036. eCollection 2014. PLoS One. 2014. PMID: 24637791 Free PMC article. - Interventions for treating hyperemesis gravidarum: a Cochrane systematic review and meta-analysis.
Boelig RC, Barton SJ, Saccone G, Kelly AJ, Edwards SJ, Berghella V. Boelig RC, et al. J Matern Fetal Neonatal Med. 2018 Sep;31(18):2492-2505. doi: 10.1080/14767058.2017.1342805. Epub 2017 Jul 11. J Matern Fetal Neonatal Med. 2018. PMID: 28614956 Review. - Long-term health outcomes of children born to mothers with hyperemesis gravidarum: a systematic review and meta-analysis.
Nijsten K, Jansen LAW, Limpens J, Finken MJJ, Koot MH, Grooten IJ, Roseboom TJ, Painter RC. Nijsten K, et al. Am J Obstet Gynecol. 2022 Sep;227(3):414-429.e17. doi: 10.1016/j.ajog.2022.03.052. Epub 2022 Mar 30. Am J Obstet Gynecol. 2022. PMID: 35367190 Review. - Anxiety, depression and marital satisfaction in women with hyperemesis gravidarum: A comparative cross-sectional study in Hospital Tengku Ampuan Rahimah, Klang, Malaysia.
Azlan WAW, Ramalingam M, Razali R, Abdullah MF, Rahman FNA. Azlan WAW, et al. Asia Pac Psychiatry. 2022 Mar;14(1):e12416. doi: 10.1111/appy.12416. Epub 2020 Sep 14. Asia Pac Psychiatry. 2022. PMID: 32929893
Cited by
- Nausea and vomiting in pregnancy (NVP) in Chinese pregnant women: a cross-sectional study.
Zou T, Long Z, Wang S, Yao Q. Zou T, et al. BMC Pregnancy Childbirth. 2024 Jul 16;24(1):481. doi: 10.1186/s12884-024-06686-7. BMC Pregnancy Childbirth. 2024. PMID: 39014303 Free PMC article. - The NVP QOL Questionnaire: Psychometric properties of the self-report measure of health-related quality of life for nausea and vomiting during pregnancy.
Yamada F, Kataoka Y, Minatani M, Hada A, Wakamatsu M, Kitamura T. Yamada F, et al. PCN Rep. 2022 Jun 30;1(3):e21. doi: 10.1002/pcn5.21. eCollection 2022 Sep. PCN Rep. 2022. PMID: 38868696 Free PMC article. - Diagnostic et traitement de l’hyperémèse gravidique.
Jansen LAW, Shaw V, Grooten IJ, Koot MH, Dean CR, Painter RC. Jansen LAW, et al. CMAJ. 2024 Jun 2;196(21):E734-E743. doi: 10.1503/cmaj.221502-f. CMAJ. 2024. PMID: 38830681 Free PMC article. Review. French. No abstract available. - Diagnosis and treatment of hyperemesis gravidarum.
Jansen LAW, Shaw V, Grooten IJ, Koot MH, Dean CR, Painter RC. Jansen LAW, et al. CMAJ. 2024 Apr 14;196(14):E477-E485. doi: 10.1503/cmaj.221502. CMAJ. 2024. PMID: 38621783 Free PMC article. Review. No abstract available. - Nausea and Vomiting of Pregnancy and its Management with the Dual-Release Formulation of Doxylamine and Pyridoxine.
Schleußner E, Jäkel S, Keck C, Kuhlmann K, Mangler M, Paulus WE, Eiblwieser J, Steeb T, Regidor PA. Schleußner E, et al. Geburtshilfe Frauenheilkd. 2024 Feb 8;84(2):144-152. doi: 10.1055/a-2225-5883. eCollection 2024 Feb. Geburtshilfe Frauenheilkd. 2024. PMID: 38344043 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical