RNA Matchmaking: Finding Cellular Pairing Partners - PubMed (original) (raw)

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RNA Matchmaking: Finding Cellular Pairing Partners

Brenton R Graveley. Mol Cell. 2016.

Abstract

RNA structure is intimately related to function, yet methods to identify base-paired RNA strands in a transcriptome-wide manner in cells have remained elusive. One recent paper in Cell and two in Molecular Cell describe related methods to identify RNA sequences that interact in living cells, setting the stage for breakthroughs in our understanding of RNA structure and function.

Copyright © 2016. Published by Elsevier Inc.

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Figures

Figure 1

Figure 1. Comparison of New RNA Structure Probing Methods

Schematic overviews of the protocols for PARIS, LIGR-seq, and SPLASH are depicted. The red and blue RNA strands are meant to indicate two different RNA molecules and that the methods can be used to identify both intra- and inter-molecular interactions. AMT and Bio-Psoralen are depicted in green intercalated between the RNA base pairs.

References

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