Insulin sensitivity, body composition and adipose depots following 12 w combined endurance and strength training in dysglycemic and normoglycemic sedentary men - PubMed (original) (raw)

Comparative Study

. 2016 Oct;122(4):167-179.

doi: 10.1080/13813455.2016.1202985. Epub 2016 Jul 31.

Jørgen Jensen 3, Frode Norheim 1, Hanne Løvdal Gulseth 2, Daniel Steensen Tangen 3, Kristoffer Jensen Kolnes 3, Ansgar Heck 2 4, Tryggve Storås 5, Guro Grøthe 3, Marius Adler Dahl 3, Anders Kielland 1, Torgeir Holen 1, Hans Jørgen Noreng 6, Hans Kristian Stadheim 3, Atle Bjørnerud 5 7, Egil Ivar Johansen 3, Birgitte Nellemann 3 8, Kåre Inge Birkeland 2 4, Christian A Drevon 1

Affiliations

Comparative Study

Insulin sensitivity, body composition and adipose depots following 12 w combined endurance and strength training in dysglycemic and normoglycemic sedentary men

Torgrim Mikal Langleite et al. Arch Physiol Biochem. 2016 Oct.

Abstract

Context: Insulin resistance and dysglycemia are associated with physical inactivity and adiposity, and may be improved by exercise.

Objective: Investigate the effect of exercise on insulin sensitivity, body composition and adipose depots in sedentary men with (n = 11) or without (n = 11) overweight and dysglycemia.

Material and methods: Euglycemic-hyperinsulinemic clamp, ankle-to-neck MRI, MRS, muscle and adipose tissue biopsies before and after 12 weeks combined strength and endurance exercise.

Results: Insulin sensitivity, VO2max, strength, whole-body and muscle fat content, and abdominal adipose depots were improved without obvious differences between normo- and dysglycemic men. Hepatic fat, waist circumference and subcutaneous adipose tissue were reduced in the dysglycemic group. For both groups plasma adiponectin was reduced, whereas IL-6 was unchanged. Visceral fat was preferentially lost compared with other adipose depots.

Discussion and conclusion: Body composition, fat distribution and insulin sensitivity improved following training in sedentary middle-aged men with and without dysglycemia.

Keywords: Adipokines; muscle fat; myokines; prediabetes; visceral fat.

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