Human gut microbiota plays a role in the metabolism of drugs - PubMed (original) (raw)
Review
. 2016 Sep;160(3):317-26.
doi: 10.5507/bp.2016.039. Epub 2016 Aug 2.
Affiliations
- PMID: 27485182
- DOI: 10.5507/bp.2016.039
Free article
Review
Human gut microbiota plays a role in the metabolism of drugs
Lenka Jourova et al. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016 Sep.
Free article
Abstract
Background and aims: The gut microbiome, an aggregate genome of trillions of microorganisms residing in the human gastrointestinal tract, is now known to play a critical role in human health and predisposition to disease. It is also involved in the biotransformation of xenobiotics and several recent studies have shown that the gut microbiota can affect the pharmacokinetics of orally taken drugs with implications for their oral bioavailability.
Methods: Review of Pubmed, Web of Science and Science Direct databases for the years 1957-2016.
Results and conclusions: Recent studies make it clear that the human gut microbiota can play a major role in the metabolism of xenobiotics and, the stability and oral bioavailability of drugs. Over the past 50 years, more than 30 drugs have been identified as a substrate for intestinal bacteria. Questions concerning the impact of the gut microbiota on drug metabolism, remain unanswered or only partially answered, namely (i) what are the molecular mechanisms and which bacterial species are involved? (ii) What is the impact of host genotype and environmental factors on the composition and function of the gut microbiota, (iii) To what extent is the composition of the intestinal microbiome stable, transmissible, and resilient to perturbation? (iv) Has past exposure to a given drug any impact on future microbial response, and, if so, for how long? Answering such questions should be an integral part of pharmaceutical research and personalised health care.
Keywords: bioavailability; cytochromes P450; gut microbiota; metabolism of drugs; microbiome.
Similar articles
- Drug Metabolism by the Host and Gut Microbiota: A Partnership or Rivalry?
Swanson HI. Swanson HI. Drug Metab Dispos. 2015 Oct;43(10):1499-504. doi: 10.1124/dmd.115.065714. Epub 2015 Aug 10. Drug Metab Dispos. 2015. PMID: 26261284 Free PMC article. Review. - Chemical transformation of xenobiotics by the human gut microbiota.
Koppel N, Maini Rekdal V, Balskus EP. Koppel N, et al. Science. 2017 Jun 23;356(6344):eaag2770. doi: 10.1126/science.aag2770. Science. 2017. PMID: 28642381 Free PMC article. Review. - Chemical Metabolism of Xenobiotics by Gut Microbiota.
Nakov R, Velikova T. Nakov R, et al. Curr Drug Metab. 2020;21(4):260-269. doi: 10.2174/1389200221666200303113830. Curr Drug Metab. 2020. PMID: 32124693 Review. - Impact of gut microbiota on drug metabolism: an update for safe and effective use of drugs.
Noh K, Kang YR, Nepal MR, Shakya R, Kang MJ, Kang W, Lee S, Jeong HG, Jeong TC. Noh K, et al. Arch Pharm Res. 2017 Dec;40(12):1345-1355. doi: 10.1007/s12272-017-0986-y. Epub 2017 Nov 27. Arch Pharm Res. 2017. PMID: 29181640 Review. - Could the gut microbiota reconcile the oral bioavailability conundrum of traditional herbs?
Chen F, Wen Q, Jiang J, Li HL, Tan YF, Li YH, Zeng NK. Chen F, et al. J Ethnopharmacol. 2016 Feb 17;179:253-64. doi: 10.1016/j.jep.2015.12.031. Epub 2015 Dec 23. J Ethnopharmacol. 2016. PMID: 26723469 Review.
Cited by
- Gut Microbiota Disruption in Hematologic Cancer Therapy: Molecular Insights and Implications for Treatment Efficacy.
Guevara-Ramírez P, Cadena-Ullauri S, Paz-Cruz E, Ruiz-Pozo VA, Tamayo-Trujillo R, Cabrera-Andrade A, Zambrano AK. Guevara-Ramírez P, et al. Int J Mol Sci. 2024 Sep 24;25(19):10255. doi: 10.3390/ijms251910255. Int J Mol Sci. 2024. PMID: 39408584 Free PMC article. Review. - Gut microbiome perturbation and its correlation with tylosin pharmacokinetics in healthy and infected pigs.
Lee EB, Lee GY, Hossain MA, Awji EG, Park SC. Lee EB, et al. Sci Rep. 2024 Aug 12;14(1):18670. doi: 10.1038/s41598-024-69566-2. Sci Rep. 2024. PMID: 39134586 Free PMC article. - New Perspectives on the Risks of Hydroxylated Polychlorinated Biphenyl (OH-PCB) Exposure: Intestinal Flora α-Glucosidase Inhibition.
Qin G, Jia R, Xue J, Chen L, Li Y, Luo W, Wu X, An T, Fang Z. Qin G, et al. Toxics. 2024 Mar 24;12(4):237. doi: 10.3390/toxics12040237. Toxics. 2024. PMID: 38668460 Free PMC article. - Application of artificial intelligence approaches to predict the metabolism of xenobiotic molecules by human gut microbiome.
Malwe AS, Sharma VK. Malwe AS, et al. Front Microbiol. 2023 Dec 5;14:1254073. doi: 10.3389/fmicb.2023.1254073. eCollection 2023. Front Microbiol. 2023. PMID: 38116528 Free PMC article. Review. - Pharmacomicrobiomics and Drug-Infection Interactions: The Impact of Commensal, Symbiotic and Pathogenic Microorganisms on a Host Response to Drug Therapy.
Torres-Carrillo N, Martínez-López E, Torres-Carrillo NM, López-Quintero A, Moreno-Ortiz JM, González-Mercado A, Gutiérrez-Hurtado IA. Torres-Carrillo N, et al. Int J Mol Sci. 2023 Dec 4;24(23):17100. doi: 10.3390/ijms242317100. Int J Mol Sci. 2023. PMID: 38069427 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous