Platinum-induced hearing loss after treatment for childhood cancer - PubMed (original) (raw)

References to studies included in this review

Bertolini 2004 {published data only}

1. 1. Bertolini P, Lassalle M, Mercier G, Raquin MA, Izzi G, Corradini N, et al. Platinum compound‐related ototoxicity in children: long‐term follow‐up reveals continuous worsening of hearing loss. Journal of Pediatric Hematology/Oncology 2004;26(10):649‐55. - PubMed

Cushing 2004 {published data only}

1. 1. Cushing B, Giller R, Cullen JW, Marina NM, Lauer SJ, Olson TA, et al. Randomized comparison of combination chemotherapy with etoposide, bleomycin, and either high‐dose or standard‐dose cisplatin in children and adolescents with high‐risk malignant germ cell tumors: a pediatric intergroup study ‐ Pediatric Oncology Group 9049 and Children's Cancer Group 8882. Journal of Clinical Oncology 2004;22(13):2691‐700. - PubMed

Hudson 2013 {published data only}

1. 1. Hudson MM, Ness KK, Gurney JG, Mulrooney DA, Chemaitilly W, Krull KR, et al. Clinical ascertainment of health outcomes among adults treated for childhood cancer. JAMA 2013;309(22):2371‐81 Erratum in: JAMA (2013);310(1):99. - PMC - PubMed

Jehanne 2009 {published data only}

1. 1. Jehanne M, Lumbroso‐Le Rouic L, Savignoni A, Aerts I, Mercier G, Bours D, et al. Analysis of ototoxicity in young children receiving carboplatin in the context of conservative management of unilateral or bilateral retinoblastoma. Pediatric Blood & Cancer 2009;52(5):637‐43. - PubMed

Kennedy 2014 {published data only}

1. 1. Kennedy C, Bull K, Chevignard M, Culliford D, Dörr HG, Doz F, et al. Quality of survival and growth in children and young adults in the PNET4 European controlled trial of hyperfractionated versus conventional radiation therapy for standard‐risk medulloblastoma. International Journal of Radiation Oncology Biology Physics 2014;88(2):292‐300. - PubMed

Lambert 2008 {published and unpublished data}

1. 1. Lambert MP, Shields C, Meadows AT. A retrospective review of hearing in children with retinoblastoma treated with carboplatin‐based chemotherapy. Pediatric Blood & Cancer 2008;50(2):223‐6. - PubMed

Landier 2014 {published data only}

1. 1. Landier W, Knight K, Wong FL, Lee J, Thomas O, Kim H, et al. Ototoxicity in children with high‐risk neuroblastoma: prevalence, risk factors, and concordance of grading scales ‐ a report from the Children's Oncology Group. Journal of Clinical Oncology 2014;32(6):527‐34. - PMC - PubMed

Mandell 1999 {published data only}

1. 1. Mandell LR, Kadota R, Freeman C, Douglass EC, Fontanesi J, Cohen ME, et al. There is no role for hyperfractionated radiotherapy in the management of children with newly diagnosed diffuse intrinsic brainstem tumors: results of a Pediatric Oncology Group phase III trial comparing conventional vs. hyperfractionated radiotherapy. International Journal of Radiation Oncology, Biology, Physics 1999;43(5):959‐64. - PubMed

Peleva 2014 {published data only}

1. 1. Peleva E, Emami N, Alzahrani M, Bezdjian A, Gurberg J, Carret AS, et al. Incidence of platinum‐induced ototoxicity in pediatric patients in Quebec. Pediatric Blood & Cancer 2014;61(11):2012‐7. - PubMed

Perilongo 2009 {published data only}

1. 1. Perilongo G, Maibach R, Shafford E, Brugieres L, Brock P, Morland B, et al. Cisplatin versus cisplatin plus doxorubicin for standard‐risk hepatoblastoma. New England Journal of Medicine 2009;361:1662‐70. - PubMed

Shields 2002 {published data only}

1. 1. Shields CL, Honavar SG, Meadows AT, Shields JA, Demirci H, Singh A, et al. Chemoreduction plus focal therapy for retinoblastoma: factors predictive of need for treatment with external beam radiotherapy or enucleation. American Journal of Ophthalmology 2002;133(5):657‐64. - PubMed

Shields 2006 {published and unpublished data}

1. 1. Shields CL, Mashayekhi A, Au AK, Czyz C, Leahey A, Meadows AT, et al. The International Classification of Retinoblastoma Predicts Chemoreduction Success. Ophthalmology 2006;113:2276‐80. - PubMed

Simon 2002 {published data only}

1. 1. Simon T, Hero B, Dupuis W, Selle B, Berthold F. The incidence of hearing impairment after successful treatment of neuroblastoma. Klinische Padiatrie 2002;214(4):149‐52. - PubMed

References to studies excluded from this review

Aksnes 2009 {published data only}

1. 1. Aksnes LH, Bauer HCF, Dahl AA, Fossa SD, Hjorth L, Jebsen N, et al. Health status at long‐term follow‐up in patients treated for extremity localized Ewing sarcoma or osteosarcoma: a Scandinavian Sarcoma Group Study. Pediatric Blood & Cancer 2009;53:84‐9. - PubMed

Altaf 2013 {published data only}

1. 1. Altaf S, Enders F, Jeavons E, Krailo M, Barkauskas DA, Meyers P, et al. High‐BMI at diagnosis is associated with inferior survival in patients with osteosarcoma: a report from the Children's Oncology Group. Pediatric Blood & Cancer 2013;60(12):2042‐6. - PubMed

Ansari 2010 {published and unpublished data}

1. 1. Ansari S, Parhyscar J. Hearing loss in pediatric oncology patients cisplatin regimens. Pediatric Blood & Cancer 2010:1008.

Armstrong 2010 {published data only}

1. 1. Armstrong GT, Conklin H, Huang S, Gajjar A, Merchant TE, Hudson M, et al. Long‐term survival & health outcomes after diagnosis of low grade glioma (ii30). International Symposium on Pediatric Neuro‐Oncology. 2010.

Bacci 2005 {published data only}

1. 1. Bacci G, Longhi A, Fagioli F, Briccoli A, Versari M, Picci P (2005). Adjuvant and neoadjuvant chemotherapy for osteosarcoma of the extremities: 27 year experience at Rizzoli Institute, Italy. European Journal of Cancer 2005;41:2836‐45. - PubMed

Baker 2010 {published data only}

1. 1. Baker DL, Schmidt ML, Cohn SL, Maris JM, London WB, Buxton A, et al. Outcome after reduced chemotherapy for intermediate‐risk neuroblastoma. New England Journal of Medicine 2010;363:1313‐23. - PMC - PubMed

Bass 2014b {published data only}

1. 1. Bass JK, Huang J, Onar‐Thomas A, Chang KW, Bhagat SP, Chintagumpala M, et al. Concordance between the Chang and the International Society of Pediatric Oncology (SIOP) ototoxicity grading scales in patients treated with cisplatin for medulloblastoma. Pediatric Blood & Cancer 2014;61(4):601‐5. - PMC - PubMed

Batra 2015 {published data only}

1. 1. Batra A, Thakar A, Bakhshi S. Ototoxicity in retinoblastoma survivors treated with carboplatin based chemotherapy: a cross‐sectional study of 116 patients. Pediatric Blood & Cancer 2015;62(11):2060. - PubMed

Berthold 2005 {published data only}

1. 1. Berthold F, Boos J, Burdach S, Erttmann R, Henze G, Hermann J, et al. Myeloablative megatherapy with autologous stem‐cell rescue versus oral maintenance chemotherapy as consolidation treatment in patients with high‐risk neuroblastoma: a randomised controlled trial. Lancet Oncology 2005;6:649‐58. - PubMed

Bostrom 1984 {published data only}

1. 1. Bostrom B, Woods WG, Ramsay NK, Krivit W, Levine P, Nesbit ME Jr. Cisplatin, vinblastine, and bleomycin (CVB) therapy for relapsed disseminated neuroblastoma. Cancer Treatment Reports 1984;68(9):1157‐8. - PubMed

Bramwell 1979 {published data only}

1. 1. Bramwell VH, Brugarolas A, Mouridsen HT, Cheix F, Jager R, Oosterom AT, et al. E.O.R.T.C. phase II study of cisplatin in cyvadic‐resistant soft tissue sarcoma. European Journal of Cancer 1979;15(12):1511‐3. - PubMed

Brinkman 2015 {published data only}

1. 1. Brinkman TM, Bass JK, Li Z, Ness KK, Gajjar A, Pappo AS, et al. Treatment‐induced hearing loss and adult social outcomes in survivors of childhood CNS and non‐CNS solid tumors: results from the St. Jude Lifetime Cohort Study. Cancer 2015;121(22):4053‐61. - PMC - PubMed

Brock 1988 {published data only}

1. 1. Brock P, Pritchard J, Bellman S, Pinkerton CR. Ototoxicity of high‐dose cis‐platinum in children. Medical and Pediatric Oncology 1988;16(5):368‐9. - PubMed

Brock 1991 {published data only}

1. 1. Brock PR, Bellman SC, Yeomans EC, Pinkerton CR, Pritchard J. Cisplatin ototoxicity in children: a practical grading system. Medical and Pediatric Oncology 1991;19:295‐300. - PubMed

Buckner 2006 {published data only}

1. 1. Buckner JC, Ballman KV, Michalak JC, Burton GV, Cascino TL, Schomberg PJ, et al. Phase III trial of carmustine and cisplatin compared with carmustine alone and standard radiation therapy or accelerated radiation therapy in patients with glioblastoma multiforme: North Central Cancer Treatment Group 93‐72‐52 and Southwest Oncology Group 9503 Trials. Journal of Clinical Oncology 2006;24(24):3871‐9. - PubMed

Calvo 1979 {published data only}

1. 1. Calvo D, Pat YZ, Wallace S, Hersch EM, Benjamin RS, Pritchard J, et al. Phase I trial of percutaneous intra‐arterial (IA) cis‐diammine dichloride platinum II (CDDP) for regionally confined malignancies (C‐558). Proceedings of the American Association for Cancer Research. 1979.

Carleton 2009 {published data only}

1. 1. Carleton B, Poole R, Smith M, Leeder J, Ghannadan R, Ross C, et al. Adverse drug reaction active surveillance: developing a national network in Canada's children's hospitals. Pharmacoepidemiology and Drug Safety 2009;18(8):713‐21. - PubMed

Carleton 2014a {published data only}

1. 1. Carleton BC, Ross CJ, Bhavsar AP, Lee JW, Visscher H, Rassekh SR, et al. Response to "Evaluation of pharmacogenetic markers to predict the risk of cisplatin‐induced ototoxicity". Clinical Pharmacology and Therapeutics 2014;96(2):158. - PubMed

Carleton 2014b {published data only}

1. 1. Carleton BC, Ross CJ, Bhavsar AP, Amstutz U, Pussegoda K, Visscher H, et al. Role of TPMT and COMT genetic variation in cisplatin‐induced ototoxicity. Clinical Pharmacology and Therapeutics 2014;95(3):253. - PubMed

Carr 2010 {published data only}

1. 1. Carr BI, Kondragunta V, Buch SC, Branch RA. Therapeutic equivalence in survival for hepatic arterial chemoembolization and yttrium 90 microsphere treatments in unresectable hepatocellular carcinoma: a two‐cohort study. Cancer 2010;116:1305‐14. - PMC - PubMed

Castel 1995 {published data only}

1. 1. Castel V, Badal MD, Bezanilla JL, Llombart A, Ruiz‐Jimenez JI, Sanchez de TJ, et al. Treatment of stage III neuroblastoma with emphasis on intensive induction chemotherapy: a report from the Neuroblastoma Group of the Spanish Society of Pediatric Oncology. Medical and Pediatric Oncology 1995;24(1):29‐35. - PubMed

Chang 2010 {published data only}

1. 1. Chang KW, Chinosornvatana N. Practical grading system for evaluating cisplatin ototoxicity in children. Journal of Clinical Oncology 2010;28:1788‐95. - PubMed

Chantada 2004 {published and unpublished data}

1. 1. Chantada G, Fandino A, Davila MTG, Manzitti J, Raslawski E, Casak S, et al. Results of a prospective study for the treatment of retinoblastoma. Cancer 2004;100:834‐42. - PubMed

Chen 2014 {published data only}

1. 1. Chen CA, Lin H, Weng CS, Wen KC, Lu CH, Chou HH, et al. Outcome of 3‐day bleomycin, etoposide and cisplatin chemotherapeutic regimen for patients with malignant ovarian germ cell tumours: a Taiwanese Gynecologic Oncology Group study. European Journal of Cancer 2014;50(18):3161‐7. - PubMed

Cohen 1991 {published data only}

1. 1. Cohen BH, Zweidler P, Goldwein JW, Molloy J, Packer RJ. Ototoxic effect of cisplatin in children with brain tumors. Pediatric Neurosurgery 1991;16:292‐6. - PubMed

Corder 1979 {published data only}

1. 1. Corder MP, Leimert JT, Panther SK, Elliott TE. A phase II study of cis‐platinum II diamminedichloride (CPDD) in lymphoma (C‐38). Proceedings of the American Association for Cancer Research. 1979.

Coze 1997 {published data only}

1. 1. Coze C, Hartmann O, Michon J, Frappaz D, Dusol F, Rubie H, et al. NB87 induction protocol for stage 4 neuroblastoma in children over 1 year of age: a report from the French Society of Pediatric Oncology. Journal of Clinical Oncology 1997;15(12):3433‐40. - PubMed

Diez 1985 {published data only}

1. 1. Diez B, Monges J, Muriel FS. Evaluation of cisplatin in children with recurrent brain tumors. Cancer Treatment Reports 1985;69:911‐3. - PubMed

Di Pinto 2012 {published data only}

1. 1. Pinto M, Conklin HM, Li C, Merchant TE. Learning and memory following conformal radiation therapy for pediatric craniopharyngioma and low‐grade glioma. International Journal of Radiation Oncology Biology Physics 2012;84(3):e363‐9. - PMC - PubMed

Dominici 1989 {published data only}

1. 1. Dominici C, Clerico A, Castello MA. Chemotherapy of regional or metastatic neuroblastoma with high‐dose cisplatin by continuous intravenous infusion and etoposide. Rivista Italiana di Pediatria 1989;15:373‐8.

Einhorn 2006 {published data only}

1. 1. Einhorn LH, Foster RS. Bleomycin, etoposide, and cisplatin for three cycles compared with etoposide and cisplatin for four cycles in good‐risk germ cell tumors: is there a preferred regimen?. Journal of Clinical Oncology 2006;24:2597‐98. - PubMed

Einhorn 2007 {published data only}

1. 1. Einhorn LH, Williams SD, Chamness A, Brames MJ, Perkins SM, Abonour R. High‐dose chemotherapy and stem‐cell rescue for metastatic germ‐cell tumors. New England Journal of Medicine 2007;357(4):340‐8. - PubMed

Ekhart 2008 {published data only}

1. 1. Ekhart C, Rodenhuis S, Smits PHM, Beijnen JH, Huitema ADR. Relations between polymorphisms in drug‐metabolising enzymes and toxicity of chemotherapy with cyclophosphamide, thiotepa and carboplatin. Pharmacogenetics and Genomics 2008;18:1009‐15. - PubMed

Ettinger 1994 {published data only}

1. 1. Ettinger LJ, Gaynon PS, Krailo MD, Ru N, Baum ES, Siegel SE, et al. A phase II study of carboplatin in children with recurrent or progressive solid tumors. A report from the Childrens Cancer Group. Cancer 1994;73(4):1297‐301. - PubMed

Flege 2004 {published data only}

1. 1. Flege S, Bielack S. Goal and results of the COSS study. Handchirurgie, Mikrochirurgie, Plastische Chirurgie 2004;36(5):282‐8. - PubMed

Fosså 2003 {published data only}

1. 1. Fosså SD, Wit R, Roberts JT, Wilkinson PM, Mulder PH, Mead GM, et al. Quality of life in good prognosis patients with metastatic germ cell cancer: a prospective study of the European Organization for Research and Treatment of Cancer Genitourinary Group/Medical Research Council Testicular Cancer Study Group (30941/TE20). Journal of Clinical Oncology 2003;21(6):1107‐18. - PubMed

Fouladi 2005 {published data only}

1. 1. Fouladi M, Gilger E, Kocak M, Wallace D, Buchanan G, Reeves C, et al. Intellectual and functional outcome of children 3 years old or younger who have CNS malignancies. Journal of Clinical Oncology 2005;23:7152‐60. - PubMed

Fox 2009 {published data only}

1. 1. Fox E, Citrin D, Balis FM. The legacy of cancer therapy in children. Journal of the National Cancer Institute 2009;101(16):1105‐7. - PubMed

Fuchs 1998 {published data only}

1. 1. Fuchs N, Bielack SS, Epler D, Bieling P, Delling G, Korholz D, et al. Long‐term results of the co‐operative German‐Austrian‐Swiss osteosarcoma study group's protocol COSS‐86 of intensive multidrug chemotherapy and surgery for osteosarcoma of the limbs. Annals of Oncology 1998;9:893‐99. - PubMed

Fuchs 1999 {published data only}

1. 1. Fuchs J, Bode U, Schweinitz DV, Weinel P, Erttmann R, Harms D, et al. Analysis of treatment efficiency of carboplatin and etoposide in combination with radical surgery in advanced and recurrent childhood hepatoblastoma: a report of the German cooperative pediatric liver tumor study HB 89 and HB 94. Klinische Padiatrie 1999;211:305‐9. - PubMed

Gaynon 1979 {published data only}

1. 1. Gaynon P, Baum E, Greenberg L, Krivit W, Hammond D, Taylor S. A phase II trial of cis‐platinum diammine dichloride (DDP) (NSC 119825) in refractory childhood tumors: a CCSG trial (C‐424). Proceedings of the American Association for Cancer Research. 1979.

Germà Lluch 1984 {published data only}

1. 1. Germà Lluch JR, Izquierdo Font A, Barnadas Molins A, Arcusa Lanza MA, Ojeda González B. Delayed platinum diamminodichloride toxicity in patients with germ tumors of the gonads. Medicina Clinica 1984;82(10):442‐5. - PubMed

Gnekow 2004 {published data only}

1. 1. Gnekow AK, Kortmann RD, Pietsch T, Emser A. Low grade chiasmatic‐hypothalamic glioma ‐ carboplatin and vincristin chemotherapy effectively defers radiotherapy within a comprehensive treatment strategy: Report from the multicenter treatment study for children and adolescents with a low grade glioma ‐ HIT‐LGG 1996 ‐ of the Society of Pediatric Oncology and Hematology (GPOH). Klinische Pädiatrie 2004;216:331‐42. - PubMed

Gobel 1989 {published data only}

1. 1. Gobel U, Bamberg M, Haas RJ, Bokkerink JPM, Bramswig G, Calaminus G, et al. Non‐testicular germ cell tumors: analysis of the MAKEI 83/86 therapy study and protocol changes for the follow‐up study. Klinische Padiatrie 1989;201:247‐60. - PubMed

Göbel 1990 {published data only}

1. 1. Göbel U, Haas RJ, Calaminus G, Bamberg M, Bökkerink EB, Engert J, et al. Treatment of germ cell tumors in children: results of European trials for testicular and non‐testicular primary sites. Critical Reviews in Oncology/Hematolology 1990;10(2):89‐98. - PubMed

Green 2008 {published data only}

1. 1. Green DM. Chemotherapy for the treatment of children and adolescents with malignant germ cell tumors. Journal of Clinical Oncology 2008;26(20):3297‐8. - PubMed

Grewal 2010 {published data only}

1. 1. Grewal S, Merchant T, Reymond R, McInerney M, Hodge C, Shearer P. Auditory late effects of childhood cancer therapy: a report from the Children's Oncology Group. Pediatrics 2010;125(4):e938‐50. - PMC - PubMed

Grill 2006 {published data only}

1. 1. Grill J, Dufour C, Kalifa C. High‐dose chemotherapy in children with newly‐diagnosed medulloblastoma. Lancet Oncology 2006;7(10):787‐9. - PubMed

Gurney 2007 {published data only}

1. 1. Gurney JG, Tersak JM, Ness KK, Landier W, Matthay KK, Schmidt ML. Hearing loss, quality of life, and academic problems in long‐term neuroblastoma survivors: a report from the Children's Oncology Group. Pediatrics 2007;120:e1229‐36. - PubMed

Gurney 2014 {published data only}

1. 1. Gurney JG, Bass JK, Onar‐Thomas A, Huang J, Chintagumpala M, Bouffet E, et al. Evaluation of amifostine for protection against cisplatin‐induced serious hearing loss in children treated for average‐risk or high‐risk medulloblastoma. Neuro‐Oncology 2014;16(6):848‐55. - PMC - PubMed

Hagleitner 2011 {published data only}

1. 1. Hagleitner MM, Hoogerbrugge PM, Graaf WTA, Flucke U, Schreuder HWB, Loo DMWM. Age as prognostic factor in patients with osteosarcoma. Bone 2011;49:1173‐7. - PubMed

Hagleitner 2012a {published data only}

1. 1. Hagleitner MM, Bont ES, Loo DM. Survival trends and long‐term toxicity in pediatric patients with osteosarcoma. Sarcoma 2012;2012:636405. - PMC - PubMed

Hagleitner 2012b {published and unpublished data}

1. 1. Hagleitner MM, Coenen MJH, Gelderblom H, Hoogerbrugge P, Guchelaar HJ, Loo DMWM. Association of the genetic variants in the nucleotide excision repair genes XPA and XPC with cisplatin‐induced hearing loss in patients with osteosarcoma (10077). Annual Meeting of the American Society of Clinical Oncology 2012.

Hagleitner 2014 {unpublished data only}

1. 1. Hagleitner MM, Coenen MJ, Patino‐Garcia A, Bont ES, Gonzalez‐Neira A, Vos HI, et al. Influence of genetic variants in TPMT and COMT associated with cisplatin induced hearing loss in patients with cancer: two new cohorts and a meta‐analysis reveal significant heterogeneity between cohorts. PLoS One 2014;9(12):e115869. - PMC - PubMed

Hill 1975 {published data only}

1. 1. Hill JM, Loeb E, MacLellan A, Hill NO, Khan A, King JJ. Clinical studies of platinum coordination compounds in the treatment of various malignant diseases. Cancer Chemotherapy Reports 1975;59(3):647‐59. - PubMed

Hishiki 2011 {published data only}

1. 1. Hishiki T, Matsunaga T, Sasaki F, Yano M, Ida K, Horie H, et al. Outcome of hepatoblastomas treated using the Japanese Study Group for Pediatric Liver Tumor (JPLT) protocol‐2: report from the JPLT. Pediatric Surgery International 2011;27:1‐8. - PubMed

Hiyama 2010a {published data only}

1. 1. Hiyama E, Kamimatsuse A, Kamei N, Watanabe K, Hishiki T, Tajiri T, et al. Outcome of hepatoblastoma treated with the JPLT‐2 protocol from the experience of JPLT (Japanese Study Group for Pediatric Liver Tumor) study. Pediatric Blood & Cancer 2010:816.

Hiyama 2010b {published data only}

1. 1. Hiyama E, Kamimatsuse A, Kamei N, Watanabe K, Hishiki T, Tajiri T, et al. Cisplatin plus pirarubicin chemotherapy and combination ifomide, etoposide, pirarubicin, and carboplatin chemotherapy for hepatoblastoma. Annual Meeting of the American Society of Clinical Oncology. 2010.

Hiyama 2013b {published data only}

1. 1. Hiyama E, Ueda Y, Onitake Y, Kurihara S, Watanabe K, Hishiki T, et al. A cisplatin plus pirarubicin‐based JPLT2 chemotherapy for hepatoblastoma: experience and future of the Japanese Study Group for Pediatric Liver Tumor (JPLT). Pediatric Surgery International 2013;29(10):1071‐5. - PubMed

Hovi 2003 {published data only}

1. 1. Hovi L, Wikstrom S, Vettenranta K, Heikkila P, Saarinen‐Pihkala UM. Adrenocortical carcinoma in children: a role for etoposide and cisplatin adjuvant therapy? Preliminary report. Medical and Pediatric Oncology 2003;40:324‐6. - PubMed

Jakacki 2012 {published data only}

1. 1. Jakacki RI, Burger PC, Zhou T, Holmes EJ, Kocak M, Onar A, et al. Outcome of children with metastatic medulloblastoma treated with carboplatin during craniospinal radiotherapy: a children's oncology group phase I/II study. Journal of Clinical Oncology 2012;30(21):2648‐53. - PMC - PubMed

Kahn 1979 {published data only}

1. 1. Khan A, McCullough D. Use of cis‐platinum in CNS malignancy (C‐144). Proceedings of the American Association for Cancer Research. 1979.

Kamalakar 1976 {published data only}

1. 1. Kamalakar P, Wang JJ, Higby D, Freeman AI, Wallace HJ. Clinical experience with CIS diammine dichloroplatinum (DDP) in children (C‐188). Proceedings of the American Association for Cancer Research. 1976.

Kingston 1986 {published data only}

1. 1. Kingston JE, Abramovich S, Billings RJ. Assessment of the effect of chemotherapy and radiotherapy on the auditory function of children with cancer. Clinical Otolaryngology and Allied Sciences 1986;11:403‐9. - PubMed

Kortmann 2000 {published data only}

1. 1. Kortmann RD, Kuhl J, Timmermann B, Mittler U, Urban C, Budach V, et al. Postoperative neoadjuvant chemotherapy before radiotherapy as compared to immediate radiotherapy followed by maintenance chemotherapy in the treatment of medulloblastoma in childhood: results of the German prospective randomized trial HIT '91. International Journal of Radiation Oncology, Biology, Physics 2000;46(2):269‐79. - PubMed

Kreissman 2013 {published data only}

1. 1. Kreissman SG, Seeger RC, Matthay KK, London WB, Sposto R, Grupp SA, et al. Purged versus non‐purged peripheral blood stem‐cell transplantation for high‐risk neuroblastoma (COG A3973): a randomised phase 3 trial. Lancet Oncology 2013;14(10):999‐1008. - PMC - PubMed

Kremers 2003 {published data only}

1. 1. Kremers A, Langer T, Stohr W, Beck JD, Rascher W. Late effects of oncological therapy in children. Padiatrische Praxis 2003;64:47‐64.

Landier 2011 {published data only}

1. 1. Landier W, Knight KR, Wong FL, Lee JK, Thomas O, Kim H, et al. Ototoxicity in children with high‐risk neuroblastoma: prevalence, risk factors, and concordance of grading scales ‐ a report from the Children's Oncology Group (COG) (abstract number 9515). ASCO Annual Meeting. 2011. - PMC - PubMed

Landier 2012 {published data only}

1. 1. Landier W, Armenian SH, Lee J, Thomas O, Wong FL, Francisco L, et al. Yield of screening for long‐term complications using the children's oncology group long‐term follow‐up guidelines. Journal of Clinical Oncology 2012;30(35):4401‐8. - PMC - PubMed

Lanvers‐Kaminsky 2014 {published data only}

1. 1. Lanvers‐Kaminsky C, Malath I, Deuster D, Ciarimboli G, Boos J, Am Zehnhoff‐Dinnesen AG. Evaluation of pharmacogenetic markers to predict the risk of cisplatin‐induced ototoxicity. Clinical Pharmacology and Therapeutics 2014;96(2):156‐7. - PubMed

Laverdiere 2009 {published data only}

1. 1. Laverdiere C, Liu Q, Yasui Y, Nathan PC, Gurney JG, Stovall M, et al. Long‐term outcomes in survivors of neuroblastoma: a report from the childhood cancer survivor study. Journal of the National Cancer Institute 2009;101:1131‐40. - PMC - PubMed

Le Deley 2007 {published data only}

1. 1. Deley MC, Guinebretière JM, Gentet JC, Pacquement H, Pichon F, Marec‐Bérard P, et al. SFOP OS94: a randomised trial comparing preoperative high‐dose methotrexate plus doxorubicin to high‐dose methotrexate plus etoposide and ifosfamide in osteosarcoma patients. European Journal of Cancer 2007;43(4):752‐61. - PubMed

Lewis 1991 {published data only}

1. 1. Lewis IJ, Stevens MC, Pearson AD, Pinkerton CR, Barnes JM. Carboplatin activity in cisplatin treated neuroblastoma. Advances in Neuroblastoma Research 1991;366:553‐9. - PubMed

Lewis 2007 {published data only}

1. 1. Lewis IJ, Nooij MA, Whelan J, Sydes MR, Grimer R, Hogendoorn PCW, et al. Improvement in histologic response but not survival in osteosarcoma patients treated with intensified chemotherapy: a randomized phase III trial of the European Osteosarcoma Intergroup. Journal of the National Cancer Institute 2007;99:112‐28. - PubMed

Li 2004 {published data only}

1. 1. Li Y, Womer RB, Silber JH. Predicting cisplatin ototoxicity in children: the influence of age and the cumulative dose. European Journal of Cancer 2004;40(16):2445‐51. - PubMed

Lippman 1973 {published data only}

1. 1. Lippman AJ, Helson C, Helson L, Krakoff IH. Clinical trials of cis‐diamminedichloroplatinum (NSC‐119875). Cancer Chemotherapy Reports Part 1 1973;57(2):191‐200. - PubMed

Liu 2014 {published data only}

1. 1. Liu W, Tang Y, Gao L, Huang X, Luo J, Zhang S, et al. Nasopharyngeal carcinoma in children and adolescents ‐ a single institution experience of 158 patients. Radiation Oncology 2014;9:274. - PMC - PubMed

Mahoney 1982 {published data only}

1. 1. Mahoney DH Jr, Weaver T, Steuber CP, Starling KA. Cis‐platinum (CDDP) ototoxicity in pediatric patients. Proceedings of the American Society of Clinical Oncology. 1982.

Mahoney 1983 {published data only}

1. 1. Mahoney DH Jr, Weaver T, Steuber CP, Starling KA. Ototoxicity with cisplatin therapy. Journal of Pediatrics 1983;103(6):1006‐7. - PubMed

Manfredini 1996 {published data only}

1. 1. Manfredini L, Garaventa A, Barra S, Caro E, Picco P, Faraci M, et al. Health status of long term survivors after myeloablative therapy and bone marrow transplantation in children. Bone Marrow Transplantation 1996;18 Suppl 2:163‐4. - PubMed

Mann 2000 {published data only}

1. 1. Mann JR, Raafat F, Robinson K, Imeson J, Gornall P, Sokal M, et al. The United Kingdom Children's Cancer Study Group's second germ cell tumor study: carboplatin, etoposide, and bleomycin are effective treatment for children with malignant extracranial germ cell tumors, with acceptable toxicity. Journal of Clinical Oncology 2000;18(22):3809‐18. - PubMed

Marshall 2006 {published data only}

1. 1. Marshall NE, Ballman KV, Michalak JC, Schomberg PJ, Burton GV, Sandler HM, et al. Ototoxicity of cisplatin plus standard radiation therapy vs. accelerated radiation therapy in glioblastoma patients. Journal of Neuro‐Oncology 2006;77(3):315‐20. - PubMed

Mbue 2007 {published data only}

1. 1. Mbue JE, Solimando DA Jr, Waddell JA. Doxorubicin, cisplatin, high‐dose methotrexate, and ifosfamide for osteosarcoma. Hospital Pharmacy 2007;42:801‐15.

McHaney 1983 {published data only}

1. 1. McHaney VA, Thibadoux G, Hayes FA, Green AA. Hearing loss in children receiving cisplatin chemotherapy. Journal of Pediatrics 1983;102(2):314‐7. - PubMed

Meyers 2005 {published data only}

1. 1. Meyers PA, Schwartz CL, Krailo M, Kleinerman ES, Betcher D, Bernstein ML, et al. Osteosarcoma: a randomized, prospective trial of the addition of ifosfamide and/or muramyl tripeptide to cisplatin, doxorubicin, and high‐dose methotrexate. Journal of Clinical Oncology 2005;23:2004‐11. - PubMed

Montero 2005 {published data only}

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1. 1. Pussegoda K, Ross CJ, Visscher H, Yazdanpanah M, Brooks B, Rassekh SR, et al. Replication of TPMT and ABCC3 genetic variants highly associated with cisplatin‐induced hearing loss in children. Clinical Pharmacology and Therapeutics 2013;94(2):243‐51. - PMC - PubMed

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1. 1. Raney RB, Asmar L, Vassilopoulou‐Sellin R, Klein MJ, Donaldson SS, Green J, et al. Late complications of therapy in 213 children with localized, nonorbital soft‐tissue sarcoma of the head and neck: a descriptive report from the Intergroup Rhabdomyosarcoma Studies (IRS)‐II and ‐ III. IRS Group of the Children's Cancer Group and the Pediatric Oncology Group. Medical and Pediatric Oncology 1999;33(4):362‐71. - PubMed

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1. 1. Rassekh R, Ross C, Brooks B, Katzov H, Dube MP, Carleton B, et al. Identification of genetic markers of severe hearing loss in children receiving cisplatin. Pediatric Blood & Cancer 2009:733.

Rednam 2012 {published data only}

1. 1. Rednam S, Scheurer M, Adesina A, Lau C, Okcu M. Glutathione s‐transferase P1 single nucleotide polymorphism predicts permanent ototoxicity in children with medulloblastoma (i125). International Symposium on Pediatric Neuro‐Oncology. 2012. - PMC - PubMed

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Singh Chauhan 2011 {published data only}

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Suita 1994 {published data only}

1. 1. Suita S, Zaizen Y, Kaneko M, Uchino J, Takeda T, Iwafuchi M, et al. What is the benefit of aggressive chemotherapy for advanced neuroblastoma with N‐myc amplification? A report from the Japanese study group for the treatment of advanced neuroblastoma. Journal of Pediatric Surgery 1994;29:746‐50. - PubMed

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1. 1. Whitehorn H, Sibanda M, Lacerda M, Spracklen T, Ramma L, Dalvie S, et al. High prevalence of cisplatin‐induced ototoxicity in Cape Town, South Africa. South African Medical Journal 2014;104(4):288‐91. - PubMed

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Xu 2015 {published data only}

1. 1. Xu H, Robinson GW, Huang J, Lim JY, Zhang H, Bass JK, et al. Common variants in ACYP2 influence susceptibility to cisplatin‐induced hearing loss. Nature Genetics 2015;47(3):263‐6. - PMC - PubMed

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1. 1. Yancey A, Harris MS, Egbelakin A, Gilbert J, Pisoni DB, Renbarger J. Risk factors for cisplatin‐associated ototoxicity in pediatric oncology patients. Pediatric Blood & Cancer 2012;59(1):144‐8. - PMC - PubMed

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1. 1. Yang JJ, Lim JY, Huang J, Bass J, Wu J, Wang C, et al. The role of inherited TPMT and COMT genetic variation in cisplatin‐induced ototoxicity in children with cancer. Clinical Pharmacology and Therapeutics 2013;94(2):252‐9. - PMC - PubMed

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1. 1. Zage PE, Kletzel M, Murray K, Marcus R, Castleberry R, Zhang Y, et al. Outcomes of the POG 9340/9341/9342 trials for children with high‐risk neuroblastoma: a report from the children's oncology group. Pediatric Blood & Cancer 2008;51:747‐53. - PMC - PubMed

References to studies awaiting assessment

Baum 1981 {published data only}

1. 1. Baum ES, Gaynon P, Greenberg L, Krivit W, Hammond D. Phase II trial of cisplatin in refractory childhood cancer: Children's Cancer Study Group Report. Cancer Treatment Reports 1981;65(9‐10):815‐22. - PubMed

Clemens 2015 {published data only}

1. 1. Clemens E, Vries AC, Dulmen‐den Broeder E, Grotel M, Pluijm SF, Tissing WJ, et al. The influence of co‐medication on platinum‐related ototoxicity in long‐term survivors of childhood cancer: a descriptive DCOG study. 14th International Conference on Long‐Term Complications of Treatment of Children and Adolescents for Cancer. 2015:69 (abstract 111).

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1. 1. Clerico A, Robert M, Marucci G, D'Attilia FR, Dionne V, Pecoraro R, et al. Preirradiation carboplatin and etoposide in the treatment of paediatric medulloblastoma in a single institution. Pediatric Blood & Cancer 2010:1005.

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1. 1. Weiss A, Kasteler R, Kuonen R, Wengenroth L, Scheinemann K, Grotzer M, et al. Hearing impairment in Swiss childhood cancer survivors. 14th International Conference on Long‐Term Complications of Treatment of Children and Adolescents for Cancer. 2015:69‐70 (abstract 112).

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