DICERing macrophages for reprogramming TAMs - PubMed (original) (raw)
Editorial
DICERing macrophages for reprogramming TAMs
Mario Leonardo Squadrito et al. Cell Cycle. 2016 Dec.
No abstract available
Figures
Figure 1.
Suppressing DICER activity reprograms TAMs. The genetic inactivation of Dicer induces M2-like TAMs (left, light blue cell) to acquire features of M1-like TAMs (right, light green cell). This is associated with the upregulation of genes denoting a pro-inflammatory signature, including the T cell chemoattractants Cxcl9 and Cxcl10. The production of CXCL9 and 10 by the reprogrammed TAMs enhances CTL infiltration in the tumors; in turn, CTL-derived IFNγ exacerbates M1 programming of the TAMs. Restoring the expression of Let-7 in the _Dicer_-deficient TAMs using DICER-independent lentiviral vectors and a haematopoietic -cell transplantation strategy (bottom, light blue cell) attenuates the pro-inflammatory gene signature and partly rescues M2-like activation of TAMs. Conversely, blocking Let-7 activity with a LIN28A-expressing lentiviral vector (top, light green cell) prompts cultured macrophages to acquire M1-like features, including immunostimulatory properties.
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- doi: 10.1038/ncb3371
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