Calreticulin in the heart - PubMed (original) (raw)

Calreticulin in the heart

Marek Michalak et al. Mol Cell Biochem. 2004 Aug.

Abstract

Calreticulin is a Ca(2+) binding/storage chaperone resident protein of the endoplasmic reticulum. This protein plays a key role in the calreticulin/calnexin cycle and the quality control pathways in the endoplasmic reticulum. Calreticulin deficiency is lethal due to impaired cardiac development. However, over-expression of the protein in developing and postnatal heart leads to bradycardia, complete heart block and sudden death. Ultrastructural evidence indicates that the deficiency associated with the absence of calreticulin in the heart may be due to a defect in the development of the contractile apparatus and/or a defect in development of the conductive system as well as a metabolic abnormality. Collectively, we postulate that calreticulin and endoplasmic reticulum plays an important role in cardiac development and postnatal pathologies. (Mol Cell Biochem 263: 137-142, 2004).

Keywords: calcium binding proteins; cardiac arrhythmia; cardiac development; chaperone; endoplasmic reticulum.

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References

1. 1. Bioessays. 1996 Sep;18(9):719-30 - PubMed
2. 1. J Cell Biol. 1998 Aug 24;142(4):963-73 - PubMed
3. 1. Annu Rev Immunol. 1997;15:707-47 - PubMed
4. 1. J Biol Chem. 1995 Jul 28;270(30):18051-9 - PubMed
5. 1. J Cell Biol. 2000 Aug 21;150(4):731-40 - PubMed

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