Clinical Manifestations of Kidney Disease Among US Adults With Diabetes, 1988-2014 - PubMed (original) (raw)

Clinical Manifestations of Kidney Disease Among US Adults With Diabetes, 1988-2014

Maryam Afkarian et al. JAMA. 2016.

Abstract

Importance: Diabetic kidney disease is the leading cause of chronic and end-stage kidney disease in the United States and worldwide. Changes in demographics and treatments may affect the prevalence and clinical manifestations of diabetic kidney disease.

Objective: To characterize the clinical manifestations of kidney disease among US adults with diabetes over time.

Design, setting, and participants: Serial cross-sectional studies of adults aged 20 years or older with diabetes mellitus participating in National Health and Nutrition Examination Surveys from 1988 through 2014.

Exposures: Diabetes was defined as hemoglobin A1c greater than 6.5% or use of glucose-lowering medications.

Main outcomes and measures: Albuminuria (urine albumin-to-creatinine ratio ≥30 mg/g), macroalbuminuria (urine albumin-to-creatinine ratio ≥300 mg/g), reduced estimated glomerular filtration rate (eGFR <60 mL/min/1.73 m2), and severely reduced eGFR (<30 mL/min/1.73 m2), incorporating data on biological variability to estimate the prevalence of persistent abnormalities.

Results: There were 6251 adults with diabetes included (1431 from 1988-1994, 1443 from 1999-2004, 1280 from 2005-2008, and 2097 from 2009-2014). The prevalence of any diabetic kidney disease, defined as persistent albuminuria, persistent reduced eGFR, or both, did not significantly change over time from 28.4% (95% CI, 23.8%-32.9%) in 1988-1994 to 26.2% (95% CI, 22.6%-29.9%) in 2009-2014 (prevalence ratio, 0.95 [95% CI, 0.86-1.06] adjusting for age, sex, and race/ethnicity; P = .39 for trend). However, the prevalence of albuminuria decreased progressively over time from 20.8% (95% CI, 16.3%-25.3%) in 1988-1994 to 15.9% (95% CI, 12.7%-19.0%) in 2009-2014 (adjusted prevalence ratio, 0.76 [95% CI, 0.65-0.89]; P < .001 for trend). In contrast, the prevalence of reduced eGFR increased from 9.2% (95% CI, 6.2%-12.2%) in 1988-1994 to 14.1% (95% CI, 11.3%-17.0%) in 2009-2014 (adjusted prevalence ratio, 1.61 [95% CI, 1.33-1.95] comparing 2009-2014 with 1988-1994; P < .001 for trend), with a similar pattern for severely reduced eGFR (adjusted prevalence ratio, 2.86 [95% CI, 1.38-5.91]; P = .004 for trend). Significant heterogeneity in the temporal trend for albuminuria was noted by age (P = .049 for interaction) and race/ethnicity (P = .007 for interaction), with a decreasing prevalence of albuminuria observed only among adults younger than 65 years and non-Hispanic whites, whereas the prevalence of reduced GFR increased without significant differences by age or race/ethnicity. In 2009-2014, approximately 8.2 million adults with diabetes (95% CI, 6.5-9.9 million adults) had albuminuria, reduced eGFR, or both.

Conclusions and relevance: Among US adults with diabetes from 1988 to 2014, the overall prevalence of diabetic kidney disease did not change significantly, whereas the prevalence of albuminuria declined and the prevalence of reduced eGFR increased.

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Conflict of interest statement

Conflict of Interest Disclosures: The authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Hall reported receiving other from the Group Health Cooperative and the American Kidney Fund. Dr Tuttle reported receiving personal fees for serving as a consultant to Eli Lilly and Company, Amgen, Noxxon Pharma, and Boehringer-Ingelheim. Dr de Boer reported receiving personal fees for serving on advisory boards for Bayer, Boehringer-Ingelheim, Ironwood, Amgen, and Janssen; grants from Abbvie, the National Institute of Diabetes and Digestive and Kidney Diseases, the National Heart, Lung, and Blood Institute, the American Diabetes Assocation, and the Juvenile Diabetes Research Foundation; and research equipment and supplies from Abbott and MedTronic. No other disclosures were reported.

Figures

Figure

Figure. Medication Use and Trends in Clinical Targets for the Adult US Population With Diabetes by Race/Ethnicity

Error bars indicate 95% CIs; NHANES, National Health and Nutrition Examination Surveys. Participants of all races and ethnicities were included in the analyses, and estimates were reported for non-Hispanic white, non-Hispanic black, and Mexican American race/ethnicity only.

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