New vaccines: challenges of discovery - PubMed (original) (raw)

Review

New vaccines: challenges of discovery

Adel Mahmoud. Microb Biotechnol. 2016 Sep.

Abstract

Vaccines have been a major component of preventing and controlling infectious diseases. The basis for discovery of what protects is reviewed as well as new attempts in utilizing Reverse Vaccinology, RNA-RNA methods and proteome analysis are adding significantly to our knowledge. The challenge of how to define protective and defined components of microbes is still hampering efforts to discover new vaccines. Recent excitement about immunotherapy of cancer opens the way to develop vaccines against multiple malignancies.

© 2016 The Authors. Microbial Biotechnology published by John Wiley & Sons Ltd and Society for Applied Microbiology.

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Figures

Figure 1

Reverse Vaccinology applied to meningococcus serogroup B. Figure from De Gregorio, E. et al. (2014) Nature Reviews Immunology 14:505‐514, with permission.

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