Caveolin 1 Modulates Aldosterone-Mediated Pathways of Glucose and Lipid Homeostasis - PubMed (original) (raw)

A two‐week treatment with Epl in cav‐1

KO

mice (gray bars) significantly decreased

RBP

4

mRNA

in liver and fat (A and B) compared with cav‐1

KO

mice (black bars) to levels observed in control wild‐type mice (white bars). In addition, Epl treatment in cav‐1

KO

mice (gray bars) significantly decreased

NOX

4

mRNA

in fat (C) and aldose reductase

mRNA

in fat (D) compared with cav‐1

KO

mice (black bars). Finally, Epl increased both G6

PD

activity (E) and protein expression (F, top: densitometry analysis; bottom: representative immunoblot) in cav‐1

KO

mice (gray bars) compared with cav‐1

KO

mice (black bars). n=4 to 8 per group. Cav‐1 indicates caveolin 1; Epl, eplerenone; G6PD, glucose‐6‐phosphate dehydrogenase; KO, knockout; NOX4, NADPH oxidase 4; ns, not significant; RBP4, retinol binding protein 4.