Novel dynamin 2 mutations in adult T-cell acute lymphoblastic leukemia - PubMed (original) (raw)

Novel dynamin 2 mutations in adult T-cell acute lymphoblastic leukemia

Zheng Ge et al. Oncol Lett. 2016 Oct.

Abstract

Genetic mutations on signaling pathways are found in patients with T-cell acute lymphoblastic leukemia (T-ALL) and act as markers of high-risk leukemia. Mutations in dynamin 2 (DNM2) have been reported in T-ALL, particularly in early T-cell precursor-ALL. In the present study, DNM2 mutations were screened by sequencing DNM2 exons obtained by polymerase chain reaction amplification and gel purification in adult T-ALL patients. A total of 4 novel DNM2 mutations were identified in adult T-ALL patients, with a mutation rate of 9.5%, and the DNM2 mutations were found to co-exist with NOTCH1 and PHD finger protein 6, and were also associated with high-risk leukemia. A high rate of silent mutation was also found in the patients, but no significant association was found between the silent mutations and patients' clinical features. The present findings suggested the DNM2 mutations may be involved in the oncogenesis of T-ALL.

Keywords: T-cell acute lymphoblastic leukemia; adult; dynamin 2.

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Figures

Figure 1.

Figure 1.

Representative DNA sequencing chromatograms of T-cell acute lymphoblastic leukemia genomic DNA samples showing mutations in exons of DNM2. DNM2, dynamin 2; WT, wild type.

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References

    1. Pui CH, Relling MV, Downing JR. Acute lymphoblastic leukemia. N Engl J Med. 2004;350:1535–1548. doi: 10.1056/NEJMra023001. - DOI - PubMed
    1. Mody R, Li S, Dover DC, Sallan S, Leisenring W, Oeffinger KC, Yasui Y, Robison LL, Neglia JP. Twenty-five-year follow-up among survivors of childhood acute lymphoblastic leukemia: A report from the childhood cancer survivor study. Blood. 2008;111:5515–5523. doi: 10.1182/blood-2007-10-117150. - DOI - PMC - PubMed
    1. Chiaretti S, Foà R. T-cell acute lymphoblastic leukemia. Haematologica. 2009;94:160–162. doi: 10.3324/haematol.2008.004150. - DOI - PMC - PubMed
    1. Ferrando AA, Neuberg DS, Staunton J, Loh ML, Huard C, Raimondi SC, Behm FG, Pui CH, Downing JR, Gilliland DG, et al. Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia. Cancer Cell. 2002;1:75–87. doi: 10.1016/S1535-6108(02)00018-1. - DOI - PubMed
    1. Roberts KG, Mullighan CG. Genomics in acute lymphoblastic leukaemia: Insights and treatment implications. Nat Rev Clin Oncol. 2015;12:344–357. doi: 10.1038/nrclinonc.2015.38. - DOI - PubMed

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